Sequence of CPT1A_RAT

carnitine O-palmitoyltransferase

P32198

773

88125

1172518

Esser V.,Britton C.H.,Weis B.C.,Foster D.W.,McGarry J.D.

Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function.

J. Biol. Chem.

268

5817-5822

1993

1172519

de Vries Y.,Arvidson D.N.,Waterham H.R.,Cregg J.M.,Woldegiorgis G.

Functional characterization of mitochondrial carnitine palmitoyltransferases I and II expressed in the yeast Pichia pastoris.

Biochemistry

36

5285-5292

1997

1172520

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

1172521

Distler A.M.,Kerner J.,Hoppel C.L.

Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry.

Biochim. Biophys. Acta

1774

628-636

2007

1172522

Kolodziej M.P.,Zammit V.A.

Mature carnitine palmitoyltransferase I retains the N-terminus of the nascent protein in rat liver.

FEBS Lett.

327

294-296

1993

1172523

Esser V.,Kuwajima M.,Britton C.H.,Krishnan K.,Foster D.W.,McGarry J.D.

Inhibitors of mitochondrial carnitine palmitoyltransferase I limit the action of proteases on the enzyme. Isolation and partial amino acid analysis of a truncated form of the rat liver isozyme.

J. Biol. Chem.

268

5810-5816

1993

1172524

Esser V.,Brown N.F.,Cowan A.T.,Foster D.W.,McGarry J.D.

Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of carnitine palmitoyltransferase I (M-CPT I). M-CPT I is the predominant CPT I isoform expressed in both white (epididymal) and brown adipocytes.

J. Biol. Chem.

271

6972-6977

1996

1172525

Fraser F.,Corstorphine C.G.,Zammit V.A.

Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane.

Biochem. J.

323

711-718

1997

1172526

Morillas M.,Gomez-Puertas P.,Roca R.,Serra D.,Asins G.,Valencia A.,Hegardt F.G.

Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity.

J. Biol. Chem.

276

45001-45008

2001

1172527

Morillas M.,Gomez-Puertas P.,Bentebibel A.,Selles E.,Casals N.,Valencia A.,Hegardt F.G.,Asins G.,Serra D.

Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition.

J. Biol. Chem.

278

9058-9063

2003

1172528

Morillas M.,Lopez-Vinas E.,Valencia A.,Serra D.,Gomez-Puertas P.,Hegardt F.G.,Asins G.

Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal.

Biochem. J.

379

777-784

2004

1172529

Borthwick K.,Jackson V.N.,Price N.T.,Zammit V.A.

The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity.

J. Biol. Chem.

281

32946-32952

2006

1172530

Stefanovic-Racic M.,Perdomo G.,Mantell B.S.,Sipula I.J.,Brown N.F.,O'Doherty R.M.

A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels.

Am. J. Physiol.

294

0-0

2008

1172531

Jenei Z.A.,Borthwick K.,Zammit V.A.,Dixon A.M.

Self-association of transmembrane domain 2 (TM2), but not TM1, in carnitine palmitoyltransferase 1A: role of GXXXG(A) motifs.

J. Biol. Chem.

284

6988-6997

2009

1172532

Lee K.,Kerner J.,Hoppel C.L.

Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex.

J. Biol. Chem.

286

25655-25662

2011

1172533

Rao J.N.,Warren G.Z.,Estolt-Povedano S.,Zammit V.A.,Ulmer T.S.

An environment-dependent structural switch underlies the regulation of carnitine palmitoyltransferase 1A.

J. Biol. Chem.

286

42545-42554

2011