Sequence of MASP2_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
mannan-binding lectin-associated serine protease-2
O00187
Homo sapiens
686
75702
Reaction
Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile)
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MRLLTLLGLL CGSVATPLGP KWPEPVFGRL ASPGFPGEYA NDQERRWTLT APPGYRLRLY
 60 FTHFDLELSH LCEYDFVKLS SGAKVLATLC GQESTDTERA PGKDTFYSLG SSLDITFRSD
120 YSNEKPFTGF EAFYAAEDID ECQVAPGEAP TCDHHCHNHL GGFYCSCRAG YVLHRNKRTC
180 SALCSGQVFT QRSGELSSPE YPRPYPKLSS CTYSISLEEG FSVILDFVES FDVETHPETL
240 CPYDFLKIQT DREEHGPFCG KTLPHRIETK SNTVTITFVT DESGDHTGWK IHYTSTAQPC
300 PYPMAPPNGH VSPVQAKYIL KDSFSIFCET GYELLQGHLP LKSFTAVCQK DGSWDRPMPA
360 CSIVDCGPPD DLPSGRVEYI TGPGVTTYKA VIQYSCEETF YTMKVNDGKY VCEADGFWTS
420 SKGEKSLPVC EPVCGLSART TGGRIYGGQK AKPGDFPWQV LILGGTTAAG ALLYDNWVLT
480 AAHAVYEQKH DASALDIRMG TLKRLSPHYT QAWSEAVFIH EGYTHDAGFD NDIALIKLNN
540 KVVINSNITP ICLPRKEAES FMRTDDIGTA SGWGLTQRGF LARNLMYVDI PIVDHQKCTA
600 AYEKPPYPRG SVTANMLCAG LESGGKDSCR GDSGGALVFL DSETERWFVG GIVSWGSMNC
660 GEAGQYGVYT KVINYIPWIE NIISDF
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1152254
Thiel S.,Vorup-Jensen T.,Stover C.M.,Schwaeble W.J.,Laursen S.B.,Poulsen K.,Willis A.C.,Eggleton P.,Hansen S.,Holmskov U.,Reid K.B.M.,Jensenius J.C.
A second serine protease associated with mannan-binding lectin that activates complement.
Nature
386
506-510
1997
1152255
Takahashi M.,Endo Y.,Fujita T.,Matsushita M.
A truncated form of mannose-binding lectin-associated serine protease (MASP)-2 expressed by alternative polyadenylation is a component of the lectin complement pathway.
Int. Immunol.
11
859-863
1999
1152256
Stover C.M.,Thiel S.,Thelen M.,Lynch N.J.,Vorup-Jensen T.,Jensenius J.C.,Schwaeble W.J.
Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene.
J. Immunol.
162
3481-3490
1999
1152260
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
1152261
Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.
The DNA sequence and biological annotation of human chromosome 1.
Nature
441
315-321
2006
1152262
Rasmussen H.H.,Orntoft T.F.,Wolf H.,Celis J.E.
Towards a comprehensive database of proteins from the urine of patients with bladder cancer.
J. Urol.
155
2113-2119
1996
1152263
Stover C.,Endo Y.,Takahashi M.,Lynch N.,Constantinescu C.,Vorup-Jensen T.,Thiel S.,Friedl H.,Hankeln T.,Hall R.,Gregory S.,Fujita T.,Schwaeble W.
The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.
Genes Immun.
2
119-127
2001
1152264
Matsushita M.,Thiel S.,Jensenius J.C.,Terai I.,Fujita T.
Proteolytic activities of two types of mannose-binding lectin-associated serine protease.
J. Immunol.
165
2637-2642
2000
1152265
Gregory L.A.,Thielens N.M.,Matsushita M.,Sorensen R.,Arlaud G.J.,Fontecilla-Camps J.-C.,Gaboriaud C.
The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin.
J. Biol. Chem.
279
29391-29397
2004
1152266
Harmat V.,Gal P.,Kardos J.,Szilagyi K.,Ambrus G.,Vegh B.,Naray-Szabo G.,Zavodszky P.
The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions.
J. Mol. Biol.
342
1533-1546
2004
1152267
Gal P.,Harmat V.,Kocsis A.,Bian T.,Barna L.,Ambrus G.,Vegh B.,Balczer J.,Sim R.B.,Naray-Szabo G.,Zavodszky P.
A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations.
J. Biol. Chem.
280
33435-33444
2005
1152268
Stengaard-Pedersen K.,Thiel S.,Gadjeva M.,Moller-Kristensen M.,Sorensen R.,Jensen L.T.,Sjoeholm A.G.,Fugger L.,Jensenius J.C.
Inherited deficiency of mannan-binding lectin-associated serine protease 2.
N. Engl. J. Med.
349
554-560
2003
1152269
Lozano F.,Suarez B.,Munoz A.,Jensenius J.C.,Mensa J.,Vives J.,Horcajada J.P.
Novel MASP2 variants detected among North African and Sub-Saharan individuals.
Tissue Antigens
66
131-135
2005
1152270
Thiel S.,Steffensen R.,Christensen I.J.,Ip W.K.,Lau Y.L.,Reason I.J.,Eiberg H.,Gadjeva M.,Ruseva M.,Jensenius J.C.
Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms.
Genes Immun.
8
154-163
2007
1152271
Srour M.,Hamdan F.F.,Gan-Or Z.,Labuda D.,Nassif C.,Oskoui M.,Gana-Weisz M.,Orr-Urtreger A.,Rouleau G.A.,Michaud J.L.
A homozygous mutation in SLC1A4 in siblings with severe intellectual disability and microcephaly.
Clin. Genet.
88
0-0
2015