Sequence of SSPP_STAAU
EC Number:3.4.22.48
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
broad endopeptidase action on proteins including elastin, but rather limited hydrolysis of small-molecule substrates. Assays are conveniently made with hemoglobin, casein or Z-Phe-Arg-NHMec as substrate
Other sequences found for EC No. 3.4.22.48
General information:
Sequence
0 MKRNFPKLIA LSLIFSLSIT PIANAESNSN IKAKDKRHVQ VNVEDKSVPT DVRNLAQKDY
60 LSYVTSLDKI YNKEKASYTL GEPFKIYKFN KKSDGNYYFP VLNTEGNIDY IVTISPKVTK
120 DSSSSSKYTI NVSSFLSKAL NEYKDQQITI LTNSKGYYVV TQNHKAKLVL KTPRLEDKKA
180 KKTESIPTGN NVTQLKQKAS VTMPTSQFKS NNYTYNEQYV NKLENFKIRE TQGNNGWCAG
240 YTMSALLNAT YNTNKYHAEA VMRFLHPNLQ GQQFQFTGLT PREMIYFEQT QGRSPQLLNR
300 MTTYNEVDNL TKNNKGIAIL GSRVESRNGM HAGHAMAVVG NAKLNNGQEV IIIWNPWDNG
360 FMTQDAKNNV IPVSNGDHYQ WYSSIYGY
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1128473
Golonka E.,Filipek R.,Sabat A.,Sinczak A.,Potempa J.
Genetic characterization of staphopain genes in Staphylococcus aureus.
Biol. Chem.
385
1059-1067
2004
1128475
Potempa J.,Dubin A.,Korzus G.,Travis J.
Degradation of elastin by a cysteine proteinase from Staphylococcus aureus.
J. Biol. Chem.
263
2664-2667
1988
1128476
Dubin G.,Krajewski M.,Popowicz G.,Stec-Niemczyk J.,Bochtler M.,Potempa J.,Dubin A.,Holak T.A.
A novel class of cysteine protease inhibitors: solution structure of staphostatin A from Staphylococcus aureus.
Biochemistry
42
13449-13456
2003
1128477
Rzychon M.,Sabat A.,Kosowska K.,Potempa J.,Dubin A.
Staphostatins: an expanding new group of proteinase inhibitors with a unique specificity for the regulation of staphopains, Staphylococcus spp. cysteine proteinases.
Mol. Microbiol.
49
1051-1066
2003
1128478
Imamura T.,Tanase S.,Szmyd G.,Kozik A.,Travis J.,Potempa J.
Induction of vascular leakage through release of bradykinin and a novel kinin by cysteine proteinases from Staphylococcus aureus.
J. Exp. Med.
201
1669-1676
2005
1128479
Laarman A.J.,Mijnheer G.,Mootz J.M.,van Rooijen W.J.,Ruyken M.,Malone C.L.,Heezius E.C.,Ward R.,Milligan G.,van Strijp J.A.,de Haas C.J.,Horswill A.R.,van Kessel K.P.,Rooijakkers S.H.
Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis.
EMBO J.
31
3607-3619
2012
1128480
Kantyka T.,Pyrc K.,Gruca M.,Smagur J.,Plaza K.,Guzik K.,Zeglen S.,Ochman M.,Potempa J.
Staphylococcus aureus proteases degrade lung surfactant protein A potentially impairing innate immunity of the lung.
J. Innate Immun.
5
251-260
2013
