Sequence of SUB1_PLAFA
EC Number:3.4.21.62
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyses peptide amides
Other sequences found for EC No. 3.4.21.62
General information:
Sequence
0 MMLNKKVVAL CTLTLHLFCI FLCLGKEVRS EENGKIQDDA KKIVSELRFL EKVEDVIEKS
60 NIGGNEVDAD ENSFNPDTEV PIEEIEEIKM RELKDVKEEK NKNDNHNNNN NNNNISSSSS
120 SSSNTFGEEK EEVSKKKKKL RLIVSENHAT TPSFFQESLL EPDVLSFLES KGNLSNLKNI
180 NSMIIELKED TTDDELISYI KILEEKGALI ESDKLVSADN IDISGIKDAI RRGEENIDVN
240 DYKSMLEVEN DAEDYDKMFG MFNESHAATS KRKRHSTNER GYDTFSSPSY KTYSKSDYLY
300 DDDNNNNNYY YSHSSNGHNS SSRNSSSSRS RPGKYHFNDE FRNLQWGLDL SRLDETQELI
360 NEHQVMSTRI CVIDSGIDYN HPDLKDNIEL NLKELHGRKG FDDDNNGIVD DIYGANFVNN
420 SGNPMDDNYH GTHVSGIISA IGNNNIGVVG VDVNSKLIIC KALDEHKLGR LGDMFKCLDY
480 CISRNAHMIN GSFSFDEYSG IFNSSVEYLQ RKGILFFVSA SNCSHPKSST PDIRKCDLSI
540 NAKYPPILST VYDNVISVAN LKKNDNNNHY SLSINSFYSN KYCQLAAPGT NIYSTAPHNS
600 YRKLNGTSMA APHVAAIASL IFSINPDLSY KKVIQILKDS IVYLPSLKNM VAWAGYADIN
660 KAVNLAIKSK KTYINSNISN KWKKKSRYLH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
103924
Blackman M.J.,Fujioka H.,Stafford W.H.,Sajid M.,Clough B.,Fleck S.L.,Aikawa M.,Grainger M.,Hackett F.
A subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoites.
J. Biol. Chem.
273
23398-23409
1998
103925
Withers-Martinez C.,Carpenter E.P.,Hackett F.,Sajid M.,Grainger M.,Blackman M.J.
PCR-based gene synthesis as an efficient approach for expression of the A+T-rich malaria genome.
Protein Eng.
12
1113-1120
1999
103926
Sajid M.,Withers-Martinez C.,Blackman M.J.
Maturation and specificity of Plasmodium falciparum subtilisin-like protease-1, a malaria merozoite subtilisin-like serine protease.
J. Biol. Chem.
275
631-641
2000
103927
Jean L.,Hackett F.,Martin S.R.,Blackman M.J.
Functional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1.
J. Biol. Chem.
278
28572-28579
2003
103928
Withers-Martinez C.,Strath M.,Hackett F.,Haire L.F.,Howell S.A.,Walker P.A.,Christodoulou E.,Evangelos C.,Dodson G.G.,Blackman M.J.
The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
Nat. Commun.
5
3726-3726
2014
