Sequence of PDC1_YEAST

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
indolepyruvate decarboxylase
P06169
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
563
61495
Reaction
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MSEITLGKYL FERLKQVNVN TVFGLPGDFN LSLLDKIYEV EGMRWAGNAN ELNAAYAADG
 60 YARIKGMSCI ITTFGVGELS ALNGIAGSYA EHVGVLHVVG VPSISAQAKQ LLLHHTLGNG
120 DFTVFHRMSA NISETTAMIT DIATAPAEID RCIRTTYVTQ RPVYLGLPAN LVDLNVPAKL
180 LQTPIDMSLK PNDAESEKEV IDTILALVKD AKNPVILADA CCSRHDVKAE TKKLIDLTQF
240 PAFVTPMGKG SIDEQHPRYG GVYVGTLSKP EVKEAVESAD LILSVGALLS DFNTGSFSYS
300 YKTKNIVEFH SDHMKIRNAT FPGVQMKFVL QKLLTTIADA AKGYKPVAVP ARTPANAAVP
360 ASTPLKQEWM WNQLGNFLQE GDVVIAETGT SAFGINQTTF PNNTYGISQV LWGSIGFTTG
420 ATLGAAFAAE EIDPKKRVIL FIGDGSLQLT VQEISTMIRW GLKPYLFVLN NDGYTIEKLI
480 HGPKAQYNEI QGWDHLSLLP TFGAKDYETH RVATTGEWDK LTQDKSFNDN SKIRMIEIML
540 PVFDAPQNLV EQAKLTAATN AKQ
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1073682
Kellermann E.,Seeboth P.G.,Hollenberg C.P.
Analysis of the primary structure and promoter function of a pyruvate decarboxylase gene (PDC1) from Saccharomyces cerevisiae.
Nucleic Acids Res.
14
8963-8977
1986
1073683
Hohmann S.,Cederberg H.
Autoregulation may control the expression of yeast pyruvate decarboxylase structural genes PDC1 and PDC5.
Eur. J. Biochem.
188
615-621
1990
1073685
Johnston M.,Hillier L.W.,Riles L.,Albermann K.,Andre B.,Ansorge W.,Benes V.,Brueckner M.,Delius H.,Dubois E.,Duesterhoeft A.,Entian K.-D.,Floeth M.,Goffeau A.,Hebling U.,Heumann K.,Heuss-Neitzel D.,Hilbert H.,Hilger F.,Kleine K.,Koetter P.,Louis E.J.,Messenguy F.,Mewes H.-W.,Miosga T.,Moestl D.,Mueller-Auer S.,Nentwich U.,Obermaier B.,Piravandi E.,Pohl T.M.,Portetelle D.,Purnelle B.,Rechmann S.,Rieger M.,Rinke M.,Rose M.,Scharfe M.,Scherens B.,Scholler P.,Schwager C.,Schwarz S.,Underwood A.P.,Urrestarazu L.A.,Vandenbol M.,Verhasselt P.,Vierendeels F.,Voet M.,Volckaert G.,Voss H.,Wambutt R.,Wedler E.,Wedler H.,Zimmermann F.K.,Zollner A.,Hani J.,Hoheisel J.D.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
Nature
387
87-90
1997
1073686
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
1073688
Garrels J.I.,Futcher B.,Kobayashi R.,Latter G.I.,Schwender B.,Volpe T.,Warner J.R.,McLaughlin C.S.
Protein identifications for a Saccharomyces cerevisiae protein database.
Electrophoresis
15
1466-1486
1994
1073689
Norbeck J.,Blomberg A.
Gene linkage of two-dimensional polyacrylamide gel electrophoresis resolved proteins from isogene families in Saccharomyces cerevisiae by microsequencing of in-gel trypsin generated peptides.
Electrophoresis
16
149-156
1995
1073690
Lehmann H.,Fischer G.,Hubner G.,Kohnert K.D.,Schellenberger A.
The influence of steric and electronic parameters on the substrate behavior of 2-oxo acids to yeast pyruvate decarboxylase.
Eur. J. Biochem.
32
83-87
1973
1073691
Schmitt H.D.,Zimmermann F.K.
Genetic analysis of the pyruvate decarboxylase reaction in yeast glycolysis.
J. Bacteriol.
151
1146-1152
1982
1073692
Chen G.C.,Jordan F.
Brewers' yeast pyruvate decarboxylase produces acetoin from acetaldehyde: a novel tool to study the mechanism of steps subsequent to carbon dioxide loss.
Biochemistry
23
3576-3582
1984
1073693
Liesen T.,Hollenberg C.P.,Heinisch J.J.
ERA, a novel cis-acting element required for autoregulation and ethanol repression of PDC1 transcription in Saccharomyces cerevisiae.
Mol. Microbiol.
21
621-632
1996
1073694
Garrels J.I.,McLaughlin C.S.,Warner J.R.,Futcher B.,Latter G.I.,Kobayashi R.,Schwender B.,Volpe T.,Anderson D.S.,Mesquita-Fuentes R.,Payne W.E.
Proteome studies of Saccharomyces cerevisiae: identification and characterization of abundant proteins.
Electrophoresis
18
1347-1360
1997
1073695
Dickinson J.R.,Lanterman M.M.,Danner D.J.,Pearson B.M.,Sanz P.,Harrison S.J.,Hewlins M.J.
A 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae.
J. Biol. Chem.
272
26871-26878
1997
1073696
Dickinson J.R.,Harrison S.J.,Hewlins M.J.
An investigation of the metabolism of valine to isobutyl alcohol in Saccharomyces cerevisiae.
J. Biol. Chem.
273
25751-25756
1998
1073697
Flikweert M.T.,de Swaaf M.,van Dijken J.P.,Pronk J.T.
Growth requirements of pyruvate-decarboxylase-negative Saccharomyces cerevisiae.
FEMS Microbiol. Lett.
174
73-79
1999
1073698
Eberhardt I.,Cederberg H.,Li H.,Konig S.,Jordan F.,Hohmann S.
Autoregulation of yeast pyruvate decarboxylase gene expression requires the enzyme but not its catalytic activity.
Eur. J. Biochem.
262
191-201
1999
1073699
Polevoda B.,Norbeck J.,Takakura H.,Blomberg A.,Sherman F.
Identification and specificities of N-terminal acetyltransferases from Saccharomyces cerevisiae.
EMBO J.
18
6155-6168
1999
1073700
Dickinson J.R.,Harrison S.J.,Dickinson J.A.,Hewlins M.J.
An investigation of the metabolism of isoleucine to active Amyl alcohol in Saccharomyces cerevisiae.
J. Biol. Chem.
275
10937-10942
2000
1073701
Neuser F.,Zorn H.,Berger R.G.
Generation of odorous acyloins by yeast pyruvate decarboxylases and their occurrence in sherry and soy sauce.
J. Agric. Food Chem.
48
6191-6195
2000
1073702
Dickinson J.R.,Salgado L.E.,Hewlins M.J.
The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae.
J. Biol. Chem.
278
8028-8034
2003
1073703
Vuralhan Z.,Morais M.A.,Tai S.L.,Piper M.D.,Pronk J.T.
Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae.
Appl. Environ. Microbiol.
69
4534-4541
2003
1073704
Iding H.,Siegert P.,Mesch K.,Pohl M.
Application of alpha-keto acid decarboxylases in biotransformations.
Biochim. Biophys. Acta
1385
307-322
1998
1073705
Hohmann S.,Meacock P.A.
Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: genetic regulation.
Biochim. Biophys. Acta
1385
201-219
1998
1073706
Huh W.-K.,Falvo J.V.,Gerke L.C.,Carroll A.S.,Howson R.W.,Weissman J.S.,O'Shea E.K.
Global analysis of protein localization in budding yeast.
Nature
425
686-691
2003
1073707
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
1073708
Li X.,Gerber S.A.,Rudner A.D.,Beausoleil S.A.,Haas W.,Villen J.,Elias J.E.,Gygi S.P.
Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
J. Proteome Res.
6
1190-1197
2007
1073709
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
1073710
Holt L.J.,Tuch B.B.,Villen J.,Johnson A.D.,Gygi S.P.,Morgan D.O.
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Science
325
1682-1686
2009
1073711
Romagnoli G.,Luttik M.A.,Koetter P.,Pronk J.T.,Daran J.M.
Substrate specificity of thiamine pyrophosphate-dependent 2-oxo-acid decarboxylases in Saccharomyces cerevisiae.
Appl. Environ. Microbiol.
78
7538-7548
2012
1073712
Starita L.M.,Lo R.S.,Eng J.K.,von Haller P.D.,Fields S.
Sites of ubiquitin attachment in Saccharomyces cerevisiae.
Proteomics
12
236-240
2012
1073713
Branduardi P.,Longo V.,Berterame N.M.,Rossi G.,Porro D.
A novel pathway to produce butanol and isobutanol in Saccharomyces cerevisiae.
Biotechnol. Biofuels
6
68-68
2013
1073714
Dyda F.,Furey W.F. Jr.,Swaminathan S.,Sax M.,Farrenkopf B.,Jordan F.
Catalytic centers in the thiamin diphosphate dependent enzyme pyruvate decarboxylase at 2.4-A resolution.
Biochemistry
32
6165-6170
1993
1073715
Arjunan P.,Umland T.,Dyda F.,Swaminathan S.,Furey W.F. Jr.,Sax M.,Farrenkopf B.,Gao Y.,Zhang D.,Jordan F.
Crystal structure of the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from the yeast Saccharomyces cerevisiae at 2.3-A resolution.
J. Mol. Biol.
256
590-600
1996
1073716
Lu G.,Dobritzsch D.,Baumann S.,Schneider G.,Koenig S.
The structural basis of substrate activation in yeast pyruvate decarboxylase. A crystallographic and kinetic study.
Eur. J. Biochem.
267
861-868
2000