Sequence of PRTN3_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Myeloblastin
P24158
Homo sapiens
256
27807
Reaction
Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-/- > -Val-/-
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MAHRPPSPAL ASVLLALLLS GAARAAEIVG GHEAQPHSRP YMASLQMRGN PGSHFCGGTL
 60 IHPSFVLTAA HCLRDIPQRL VNVVLGAHNV RTQEPTQQHF SVAQVFLNNY DAENKLNDVL
120 LIQLSSPANL SASVATVQLP QQDQPVPHGT QCLAMGWGRV GAHDPPAQVL QELNVTVVTF
180 FCRPHNICTF VPRRKAGICF GDSGGPLICD GIIQGIDSFV IWGCATRLFP DFFTRVALYV
240 DWIRSTLRRV EAKGRP
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1064806
Labbaye C.,Musette P.,Cayre Y.E.
Wegener autoantigen and myeloblastin are encoded by a single mRNA.
Proc. Natl. Acad. Sci. U.S.A.
88
9253-9256
1991
1064807
Grimwood J.,Gordon L.A.,Olsen A.S.,Terry A.,Schmutz J.,Lamerdin J.E.,Hellsten U.,Goodstein D.,Couronne O.,Tran-Gyamfi M.,Aerts A.,Altherr M.,Ashworth L.,Bajorek E.,Black S.,Branscomb E.,Caenepeel S.,Carrano A.V.,Caoile C.,Chan Y.M.,Christensen M.,Cleland C.A.,Copeland A.,Dalin E.,Dehal P.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Garcia C.,Georgescu A.M.,Glavina T.,Gomez M.,Gonzales E.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Ho I.,Huang W.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Larionov V.,Leem S.-H.,Lopez F.,Lou Y.,Lowry S.,Malfatti S.,Martinez D.,McCready P.M.,Medina C.,Morgan J.,Nelson K.,Nolan M.,Ovcharenko I.,Pitluck S.,Pollard M.,Popkie A.P.,Predki P.,Quan G.,Ramirez L.,Rash S.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,She X.,Smith D.,Slezak T.,Solovyev V.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wagner M.,Wheeler J.,Wu K.,Xie G.,Yang J.,Dubchak I.,Furey T.S.,DeJong P.,Dickson M.,Gordon D.,Eichler E.E.,Pennacchio L.A.,Richardson P.,Stubbs L.,Rokhsar D.S.,Myers R.M.,Rubin E.M.,Lucas S.M.
The DNA sequence and biology of human chromosome 19.
Nature
428
529-535
2004
1064809
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1064810
Zimmer M.,Medcalf R.L.,Fink T.M.,Mattmann C.,Lichter P.,Jenne D.E.
Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.
Proc. Natl. Acad. Sci. U.S.A.
89
8215-8219
1992
1064811
Sturrock A.B.,Franklin K.F.,Rao G.,Marshall B.C.,Rebentisch M.B.,Lemons R.S.,Hoidal J.R.
Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen.
J. Biol. Chem.
267
21193-21199
1992
1064812
Clave E.,Molldrem J.,Hensel N.,Raptis A.,Barrett A.J.
Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia.
J. Immunother.
22
1-6
1999
1064813
Musette P.,Labbaye C.,Dorner M.H.,Cayre Y.E.,Casanova J.-L.,Kourilsky P.
Wegener's autoantigen and leukemia.
Blood
77
1398-1399
1991
1064814
Campanelli D.,Melchior M.,Fu Y.,Nakata M.,Shuman H.,Nathan C.,Gabay J.E.
Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils.
J. Exp. Med.
172
1709-1715
1990
1064815
Bories D.,Raynal M.-C.,Solomon D.H.,Darzynkiewicz Z.,Cayre Y.E.
Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells.
Cell
59
959-968
1989
1064816
Jenne D.E.,Tschopp J.,Luedemann J.,Utecht B.,Gross W.L.
Wegener's autoantigen decoded.
Nature
346
520-520
1990
1064817
Rao N.V.,Wehner N.G.,Marshall B.C.,Gray W.R.,Gray B.H.,Hoidal J.R.
Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties.
J. Biol. Chem.
266
9540-9548
1991
1064818
Wilde C.G.,Snable J.L.,Griffith J.E.,Scott R.W.
Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase.
J. Biol. Chem.
265
2038-2041
1990
1064819
Ohlsson K.,Linder C.,Rosengren M.
Monoclonal antibodies specific for neutrophil proteinase 4. Production and use for isolation of the enzyme.
Biol. Chem. Hoppe-Seyler
371
549-555
1990
1064820
Goldschmeding R.,Dolman K.M.,van den Ende M.E.,van der Meer-Gerritsen C.H.,Sonnenberg A.,von dem Borne A.E.
The relation of 29 kD C-ANCA antigen to proteinase 3.
APMIS Suppl.
19
26-27
1990
1064821
Niles J.L.,McCluskey R.T.,Ahmad M.F.,Arnaout M.A.
Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase.
Blood
74
1888-1893
1989
1064822
Gabay J.E.,Scott R.W.,Campanelli D.,Griffith J.,Wilde C.,Marra M.N.,Seeger M.,Nathan C.F.
Antibiotic proteins of human polymorphonuclear leukocytes.
Proc. Natl. Acad. Sci. U.S.A.
86
5610-5614
1989
1064823
Gaskin G.,Kendal H.,Coulthart A.,Turner N.,Pusey C.D.
Use of proteinase 3 purified by reverse phase HPLC to detect autoantibodies in systemic vasculitis.
J. Immunol. Methods
180
25-33
1995
1064824
Ludemann J.,Utecht B.,Gross W.L.
Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme.
J. Exp. Med.
171
357-362
1990
1064825
Duke-Cohan J.S.,Morimoto C.,Rocker J.A.,Schlossman S.F.
A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26).
J. Biol. Chem.
270
14107-14114
1995
1064826
Kao R.C.,Wehner N.G.,Skubitz K.M.,Gray B.H.,Hoidal J.R.
Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters.
J. Clin. Invest.
82
1963-1973
1988
1064827
Gupta S.K.,Niles J.L.,McCluskey R.T.,Arnaout M.A.
Identity of Wegener's autoantigen (p29) with proteinase 3 and myeloblastin.
Blood
76
2162-2162
1990
1064828
von Vietinghoff S.,Tunnemann G.,Eulenberg C.,Wellner M.,Cristina Cardoso M.,Luft F.C.,Kettritz R.
NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils.
Blood
109
4487-4493
2007
1064829
von Vietinghoff S.,Eulenberg C.,Wellner M.,Luft F.C.,Kettritz R.
Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing.
Clin. Exp. Immunol.
152
508-516
2008
1064830
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
1064831
Jerke U.,Rolle S.,Dittmar G.,Bayat B.,Santoso S.,Sporbert A.,Luft F.,Kettritz R.
Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation.
J. Biol. Chem.
286
7070-7081
2011
1064832
Kuckleburg C.J.,Tilkens S.B.,Santoso S.,Newman P.J.
Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils.
J. Immunol.
188
2419-2426
2012
1064833
Kuckleburg C.J.,Newman P.J.
Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function.
Arterioscler. Thromb. Vasc. Biol.
33
275-284
2013
1064834
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
1064835
Jerke U.,Marino S.F.,Daumke O.,Kettritz R.
Characterization of the CD177 interaction with the ANCA antigen proteinase 3.
Sci. Rep.
7
43328-43328
2017
1064836
Choi Y.J.,Kim S.,Choi Y.,Nielsen T.B.,Yan J.,Lu A.,Ruan J.,Lee H.R.,Wu H.,Spellberg B.,Jung J.U.
SERPINB1-mediated checkpoint of inflammatory caspase activation.
Nat. Immunol.
20
276-287
2019
1064837
Fujinaga M.,Charnaia M.M.,Halenbeck R.,Koths K.,James M.N.G.
The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies.
J. Mol. Biol.
261
267-278
1996