Sequence of GSK3B_HUMAN
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK
60 VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG
120 EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR
180 DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV
240 WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP
300 WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF
360 NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NTGDRGQTNN AASASASNST
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1065290
Stambolic V.,Woodgett J.R.
Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation.
Biochem. J.
303
701-704
1994
1065292
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
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2121-2127
2004
1065293
Lau K.F.,Miller C.C.J.,Anderton B.H.,Shaw P.C.
Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter.
Genomics
60
121-128
1999
1065294
Rhoads A.R.,Karkera J.D.,Detera-Wadleigh S.D.
Radiation hybrid mapping of genes in the lithium-sensitive wnt signaling pathway.
Mol. Psychiatry
4
437-442
1999
1065295
Boyle W.J.,Smeal T.,Defize L.H.,Angel P.,Woodgett J.R.,Karin M.,Hunter T.
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.
Cell
64
573-584
1991
1065296
Welsh G.I.,Proud C.G.
Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.
Biochem. J.
294
625-629
1993
1065297
Sutherland C.,Leighton I.A.,Cohen P.
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.
Biochem. J.
296
15-19
1993
1065298
Cross D.A.,Alessi D.R.,Cohen P.,Andjelkovich M.,Hemmings B.A.
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
Nature
378
785-789
1995
1065299
Beals C.R.,Sheridan C.M.,Turck C.W.,Gardner P.,Crabtree G.R.
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.
Science
275
1930-1934
1997
1065300
Hong Y.-R.,Chen C.-H.,Cheng D.-S.,Howng S.-L.,Chow C.-C.
Human dynamin-like protein interacts with the glycogen synthase kinase 3beta.
Biochem. Biophys. Res. Commun.
249
697-703
1998
1065301
Li Y.,Bharti A.,Chen D.,Gong J.,Kufe D.
Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin.
Mol. Cell. Biol.
18
7216-7224
1998
1065302
Delcommenne M.,Tan C.,Gray V.,Rue L.,Woodgett J.R.,Dedhar S.
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.
Proc. Natl. Acad. Sci. U.S.A.
95
11211-11216
1998
1065303
Hong Y.-R.,Chen C.-H.,Chang J.-H.,Wang S.-K.,Sy W.-D.,Chou C.-K.,Howng S.-L.
Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta.
Biochim. Biophys. Acta
1492
513-516
2000
1065304
Nikoulina S.E.,Ciaraldi T.P.,Mudaliar S.,Mohideen P.,Carter L.,Henry R.R.
Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.
Diabetes
49
263-271
2000
1065305
Frame S.,Cohen P.,Biondi R.M.
A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation.
Mol. Cell
7
1321-1327
2001
1065306
Dai F.,Yu L.,He H.,Chen Y.,Yu J.,Yang Y.,Xu Y.,Ling W.,Zhao S.
Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.
Biochem. Biophys. Res. Commun.
293
1191-1196
2002
1065307
Cho J.H.,Johnson G.V.
Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules.
J. Neurochem.
88
349-358
2004
1065308
Zhou B.P.,Deng J.,Xia W.,Xu J.,Li Y.M.,Gunduz M.,Hung M.C.
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.
Nat. Cell Biol.
6
931-940
2004
1065309
Hsu H.-C.,Lee Y.-L.,Cheng T.-S.,Howng S.-L.,Chang L.-K.,Lu P.-J.,Hong Y.-R.
Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.
Biochem. Biophys. Res. Commun.
329
1108-1117
2005
1065310
Yook J.I.,Li X.Y.,Ota I.,Fearon E.R.,Weiss S.J.
Wnt-dependent regulation of the E-cadherin repressor snail.
J. Biol. Chem.
280
11740-11748
2005
1065311
Chou H.-Y.,Howng S.-L.,Cheng T.-S.,Hsiao Y.-L.,Lieu A.-S.,Loh J.-K.,Hwang S.-L.,Lin C.-C.,Hsu C.-M.,Wang C.,Lee C.-I.,Lu P.-J.,Chou C.-K.,Huang C.-Y.,Hong Y.-R.
GSKIP is homologous to the axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta.
Biochemistry
45
11379-11389
2006
1065312
Kobayashi T.,Hino S.,Oue N.,Asahara T.,Zollo M.,Yasui W.,Kikuchi A.
Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions.
Mol. Cell. Biol.
26
898-911
2006
1065313
Yin L.,Wang J.,Klein P.S.,Lazar M.A.
Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock.
Science
311
1002-1005
2006
1065314
Garcia-Alvarez G.,Ventura V.,Ros O.,Aligue R.,Gil J.,Tauler A.
Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity.
Biochim. Biophys. Acta
1773
375-382
2007
1065315
Luo W.,Peterson A.,Garcia B.A.,Coombs G.,Kofahl B.,Heinrich R.,Shabanowitz J.,Hunt D.F.,Yost H.J.,Virshup D.M.
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.
EMBO J.
26
1511-1521
2007
1065316
Sun M.,Song L.,Li Y.,Zhou T.,Jope R.S.
Identification of an antiapoptotic protein complex at death receptors.
Cell Death Differ.
15
1887-1900
2008
1065317
Hashimoto Y.K.,Satoh T.,Okamoto M.,Takemori H.
Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity.
J. Cell. Biochem.
104
1724-1739
2008
1065318
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
1065319
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
1065320
Kandasamy A.D.,Schulz R.
Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts.
Cardiovasc. Res.
83
698-706
2009
1065321
Spengler M.L.,Kuropatwinski K.K.,Schumer M.,Antoch M.P.
A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation.
Cell Cycle
8
4138-4146
2009
1065322
Oh M.,Kim H.,Yang I.,Park J.H.,Cong W.T.,Baek M.C.,Bareiss S.,Ki H.,Lu Q.,No J.,Kwon I.,Choi J.K.,Kim K.
GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.
J. Biol. Chem.
284
28579-28589
2009
1065323
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
1065324
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
1065325
Castano Z.,Gordon-Weeks P.R.,Kypta R.M.
The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth.
J. Neurochem.
113
117-130
2010
1065326
Heyd F.,Lynch K.W.
Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.
Mol. Cell
40
126-137
2010
1065327
Xie D.,Gore C.,Liu J.,Pong R.C.,Mason R.,Hao G.,Long M.,Kabbani W.,Yu L.,Zhang H.,Chen H.,Sun X.,Boothman D.A.,Min W.,Hsieh J.T.
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis.
Proc. Natl. Acad. Sci. U.S.A.
107
2485-2490
2010
1065328
Zaoui K.,Benseddik K.,Daou P.,Salaun D.,Badache A.
ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.
Proc. Natl. Acad. Sci. U.S.A.
107
18517-18522
2010
1065329
Ali A.,Hoeflich K.P.,Woodgett J.R.
Glycogen synthase kinase-3: properties, functions, and regulation.
Chem. Rev.
101
2527-2540
2001
1065330
Lee J.,Kim M.S.
The role of GSK3 in glucose homeostasis and the development of insulin resistance.
Diabetes Res. Clin. Pract.
77
0-0
2007
1065331
Rayasam G.V.,Tulasi V.K.,Sodhi R.,Davis J.A.,Ray A.
Glycogen synthase kinase 3: more than a namesake.
Br. J. Pharmacol.
156
885-898
2009
1065332
Hundsrucker C.,Skroblin P.,Christian F.,Zenn H.M.,Popara V.,Joshi M.,Eichhorst J.,Wiesner B.,Herberg F.W.,Reif B.,Rosenthal W.,Klussmann E.
Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein.
J. Biol. Chem.
285
5507-5521
2010
1065333
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
1065334
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
1065335
Bose A.,Mouton-Liger F.,Paquet C.,Mazot P.,Vigny M.,Gray F.,Hugon J.
Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.
Brain Pathol.
21
189-200
2011
1065336
Sun L.,Lv F.,Guo X.,Gao G.
Glycogen synthase kinase 3? (GSK3?) modulates antiviral activity of zinc-finger antiviral protein (ZAP).
J. Biol. Chem.
287
22882-22888
2012
1065337
Lin S.Y.,Li T.Y.,Liu Q.,Zhang C.,Li X.,Chen Y.,Zhang S.M.,Lian G.,Liu Q.,Ruan K.,Wang Z.,Zhang C.S.,Chien K.Y.,Wu J.,Li Q.,Han J.,Lin S.C.
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.
Science
336
477-481
2012
1065338
Feijs K.L.,Kleine H.,Braczynski A.,Forst A.H.,Herzog N.,Verheugd P.,Linzen U.,Kremmer E.,Luscher B.
ARTD10 substrate identification on protein microarrays: regulation of GSK3beta by mono-ADP-ribosylation.
Cell Commun. Signal.
11
5-5
2013
1065339
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
1065340
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
1065341
Suenaga Y.,Islam S.M.,Alagu J.,Kaneko Y.,Kato M.,Tanaka Y.,Kawana H.,Hossain S.,Matsumoto D.,Yamamoto M.,Shoji W.,Itami M.,Shibata T.,Nakamura Y.,Ohira M.,Haraguchi S.,Takatori A.,Nakagawara A.
NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3beta resulting in the stabilization of MYCN in human neuroblastomas.
PLoS Genet.
10
0-0
2014
1065342
Varisli L.,Ozturk B.E.,Akyuz G.K.,Korkmaz K.S.
HN1 negatively influences the beta-catenin/E-cadherin interaction, and contributes to migration in prostate cells.
J. Cell. Biochem.
116
170-178
2015
1065343
Loh J.K.,Lin C.C.,Yang M.C.,Chou C.H.,Chen W.S.,Hong M.C.,Cho C.L.,Hsu C.M.,Cheng J.T.,Chou A.K.,Chang C.H.,Tseng C.N.,Wang C.H.,Lieu A.S.,Howng S.L.,Hong Y.R.
GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation.
Biochim. Biophys. Acta
1853
1796-1807
2015
1065344
Koo J.,Wu X.,Mao Z.,Khuri F.R.,Sun S.Y.
Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.
J. Biol. Chem.
290
14120-14129
2015
1065345
Dema A.,Schroeter M.F.,Perets E.,Skroblin P.,Moutty M.C.,Deak V.A.,Birchmeier W.,Klussmann E.
The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3beta Interaction Protein (GSKIP) Regulates beta-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3beta.
J. Biol. Chem.
291
19618-19630
2016
1065346
Lu Y.,Xie S.,Zhang W.,Zhang C.,Gao C.,Sun Q.,Cai Y.,Xu Z.,Xiao M.,Xu Y.,Huang X.,Wu X.,Liu W.,Wang F.,Kang Y.,Zhou T.
Twa1/Gid8 is a beta-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.
Cell Res.
27
1422-1440
2017
1065347
Lu Y.,Zheng X.,Hu W.,Bian S.,Zhang Z.,Tao D.,Liu Y.,Ma Y.
Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.
Oncotarget
8
54913-54924
2017
1065348
Wang D.,Zhao J.,Li S.,Wei J.,Nan L.,Mallampalli R.K.,Weathington N.M.,Ma H.,Zhao Y.
Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells.
J. Mol. Cell Biol.
10
60-73
2018
1065349
Cheng X.,Ma X.,Zhu Q.,Song D.,Ding X.,Li L.,Jiang X.,Wang X.,Tian R.,Su H.,Shen Z.,Chen S.,Liu T.,Gong W.,Liu W.,Sun Q.
Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.
Mol. Cell
73
1-15
2019
1065350
Choi J.H.,Zhong X.,McAlpine W.,Liao T.C.,Zhang D.,Fang B.,Russell J.,Ludwig S.,Nair-Gill E.,Zhang Z.,Wang K.W.,Misawa T.,Zhan X.,Choi M.,Wang T.,Li X.,Tang M.,Sun Q.,Yu L.,Murray A.R.,Moresco E.M.Y.,Beutler B.
LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.
Science
364
0-0
2019
1065351
Dajani R.,Fraser E.,Roe S.M.,Young N.,Good V.,Dale T.C.,Pearl L.H.
Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition.
Cell
105
721-732
2001
1065352
Bax B.,Carter P.S.,Lewis C.,Guy A.R.,Bridges A.,Tanner R.,Pettman G.,Mannix C.,Culbert A.A.,Brown M.J.B.,Smith D.G.,Reith A.D.
The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.
Structure
9
1143-1152
2001
1065353
Dajani R.,Fraser E.,Roe S.M.,Yeo M.,Good V.M.,Thompson V.,Dale T.C.,Pearl L.H.
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex.
EMBO J.
22
494-501
2003
