Sequence of DPYD_HUMAN

dihydropyrimidine dehydrogenase (NADP+)

Q12882

1025

111401

1051734

Yokota H.,Fernandez-Salguero P.,Furuya H.,Lin K.,McBride O.W.,Podschun B.,Schnackerz K.D.,Gonzalez F.J.

cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.

J. Biol. Chem.

269

23192-23196

1994

1051735

Johnson M.R.,Wang K.,Tillmanns S.,Albin N.,Diasio R.B.

Structural organization of the human dihydropyrimidine dehydrogenase gene.

Cancer Res.

57

1660-1663

1997

1051736

Ogura K.,Nishiyama T.,Takubo H.,Kato A.,Okuda H.,Arakawa K.,Fukushima M.,Nagayama S.,Kawaguchi Y.,Watabe T.

Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine.

Cancer Lett.

122

107-113

1998

1051738

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

1051739

Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.

The DNA sequence and biological annotation of human chromosome 1.

Nature

441

315-321

2006

1051741

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

1051742

Vreken P.,van Kuilenburg A.B.P.,Meinsma R.,Smit G.P.A.,Bakker H.D.,de Abreu R.A.,van Gennip A.H.

A point mutation in an invariant splice donor site leads to exon skipping in two unrelated Dutch patients with dihydropyrimidine dehydrogenase deficiency.

J. Inherit. Metab. Dis.

19

645-654

1996

1051743

Fernandez-Salguero P.M.,Sapone A.,Wei X.,Holt J.R.,Jones S.,Idle J.R.,Gonzalez F.J.

Lack of correlation between phenotype and genotype for the polymorphically expressed dihydropyrimidine dehydrogenase in a family of Pakistani origin.

Pharmacogenetics

7

161-163

1997

1051744

Lu Z.-H.,Zhang R.,Diasio R.B.

Purification and characterization of dihydropyrimidine dehydrogenase from human liver.

J. Biol. Chem.

267

17102-17109

1992

1051745

Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.

Lysine acetylation targets protein complexes and co-regulates major cellular functions.

Science

325

834-840

2009

1051746

Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Proc. Natl. Acad. Sci. U.S.A.

109

12449-12454

2012

1051747

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

1051748

Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J. Proteomics

96

253-262

2014

1051749

Vreken P.,van Kuilenburg A.B.P.,Meinsma R.,van Gennip A.H.

Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W.

Hum. Genet.

101

333-338

1997

1051750

Vreken P.,van Kuilenburg A.B.P.,Meinsma R.,van Gennip A.H.

Identification of novel point mutations in the dihydropyrimidine dehydrogenase gene.

J. Inherit. Metab. Dis.

20

335-338

1997

1051751

Ridge S.A.,Sludden J.,Wei X.,Sapone A.,Brown O.,Hardy S.,Canney P.,Fernandez-Salguero P.,Gonzalez F.J.,Cassidy J.,McLeod H.L.

Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer.

Br. J. Cancer

77

497-500

1998

1051752

Ridge S.A.,Sludden J.,Brown O.,Robertson L.,Wei X.,Sapone A.,Fernandez-Salguero P.M.,Gonzalez F.J.,Vreken P.,van Kuilenburg A.B.,van Gennip A.H.,McLeod H.L.

Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects.

Br. J. Clin. Pharmacol.

46

151-156

1998

1051753

Ley T.J.,Mardis E.R.,Ding L.,Fulton B.,McLellan M.D.,Chen K.,Dooling D.,Dunford-Shore B.H.,McGrath S.,Hickenbotham M.,Cook L.,Abbott R.,Larson D.E.,Koboldt D.C.,Pohl C.,Smith S.,Hawkins A.,Abbott S.,Locke D.,Hillier L.W.,Miner T.,Fulton L.,Magrini V.,Wylie T.,Glasscock J.,Conyers J.,Sander N.,Shi X.,Osborne J.R.,Minx P.,Gordon D.,Chinwalla A.,Zhao Y.,Ries R.E.,Payton J.E.,Westervelt P.,Tomasson M.H.,Watson M.,Baty J.,Ivanovich J.,Heath S.,Shannon W.D.,Nagarajan R.,Walter M.J.,Link D.C.,Graubert T.A.,DiPersio J.F.,Wilson R.K.

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

Nature

456

66-72

2008