Sequence of DHI1_HUMAN

11beta-hydroxysteroid dehydrogenase

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The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

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Draper N.,Echwald S.M.,Lavery G.G.,Walker E.A.,Fraser R.,Davies E.,Soerensen T.I.A.,Astrup A.,Adamski J.,Hewison M.,Connell J.M.,Pedersen O.,Stewart P.M.

Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism.

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Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

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2004

1049901

Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.

The DNA sequence and biological annotation of human chromosome 1.

Nature

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1049903

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

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2121-2127

2004

1049904

Moore C.C.,Mellon S.H.,Murai J.,Siiteri P.K.,Miller W.L.

Structure and function of the hepatic form of 11 beta-hydroxysteroid dehydrogenase in the squirrel monkey, an animal model of glucocorticoid resistance.

Endocrinology

133

368-375

1993

1049905

Odermatt A.,Arnold P.,Stauffer A.,Frey B.M.,Frey F.J.

The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane.

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1999

1049906

Rauz S.,Walker E.A.,Shackleton C.H.,Hewison M.,Murray P.I.,Stewart P.M.

Expression and putative role of 11 beta-hydroxysteroid dehydrogenase isozymes within the human eye.

Invest. Ophthalmol. Vis. Sci.

42

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2001

1049907

Nobel C.S.I.,Dunas F.,Abrahmsen L.B.

Purification of full-length recombinant human and rat type 1 11beta-hydroxysteroid dehydrogenases with retained oxidoreductase activities.

Protein Expr. Purif.

26

349-356

2002

1049908

Draper N.,Walker E.A.,Bujalska I.J.,Tomlinson J.W.,Chalder S.M.,Arlt W.,Lavery G.G.,Bedendo O.,Ray D.W.,Laing I.,Malunowicz E.,White P.C.,Hewison M.,Mason P.J.,Connell J.M.,Shackleton C.H.L.,Stewart P.M.

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.

Nat. Genet.

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2003

1049909

Schweizer R.A.S.,Zuercher M.,Balazs Z.,Dick B.,Odermatt A.

Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme.

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279

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2004

1049910

Hult M.,Elleby B.,Shafqat N.,Svensson S.,Rane A.,Joernvall H.,Abrahmsen L.,Oppermann U.

Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.

Cell. Mol. Life Sci.

61

992-999

2004

1049911

Frick C.,Atanasov A.G.,Arnold P.,Ozols J.,Odermatt A.

Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase.

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279

31131-31138

2004

1049912

Atanasov A.G.,Nashev L.G.,Schweizer R.A.,Frick C.,Odermatt A.

Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an oxoreductase.

FEBS Lett.

571

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2004

1049913

Nashev L.G.,Chandsawangbhuwana C.,Balazs Z.,Atanasov A.G.,Dick B.,Frey F.J.,Baker M.E.,Odermatt A.

Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids.

PLoS ONE

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0-0

2007

1049914

Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

J. Proteome Res.

8

651-661

2009

1049915

Odermatt A.,Da Cunha T.,Penno C.A.,Chandsawangbhuwana C.,Reichert C.,Wolf A.,Dong M.,Baker M.E.

Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11beta-hydroxysteroid dehydrogenase 1.

Biochem. J.

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2011

1049916

Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J. Proteomics

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253-262

2014

1049917

Tsachaki M.,Meyer A.,Weger B.,Kratschmar D.V.,Tokarz J.,Adamski J.,Belting H.G.,Affolter M.,Dickmeis T.,Odermatt A.

Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish.

J. Endocrinol.

232

323-335

2017

1049918

Beck K.R.,Kanagaratnam S.,Kratschmar D.V.,Birk J.,Yamaguchi H.,Sailer A.W.,Seuwen K.,Odermatt A.

Enzymatic interconversion of the oxysterols 7beta,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11beta-hydroxysteroid dehydrogenase type 1 and 2.

J. Steroid Biochem. Mol. Biol.

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19-28

2019

1049919

Hosfield D.J.,Wu Y.,Skene R.J.,Hilgers M.,Jennings A.,Snell G.P.,Aertgeerts K.

Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.

J. Biol. Chem.

280

4639-4648

2005

1049920

Sorensen B.,Winn M.,Rohde J.,Shuai Q.,Wang J.,Fung S.,Monzon K.,Chiou W.,Stolarik D.,Imade H.,Pan L.,Deng X.,Chovan L.,Longenecker K.,Judge R.,Qin W.,Brune M.,Camp H.,Frevert E.U.,Jacobson P.,Link J.T.

Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.

Bioorg. Med. Chem. Lett.

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527-532

2007

1049921

Yuan C.,St Jean D.J. Jr.,Liu Q.,Cai L.,Li A.,Han N.,Moniz G.,Askew B.,Hungate R.W.,Johansson L.,Tedenborg L.,Pyring D.,Williams M.,Hale C.,Chen M.,Cupples R.,Zhang J.,Jordan S.,Bartberger M.D.,Sun Y.,Emery M.,Wang M.,Fotsch C.

The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.

Bioorg. Med. Chem. Lett.

17

6056-6061

2007

1049922

Wang H.,Ruan Z.,Li J.J.,Simpkins L.M.,Smirk R.A.,Wu S.C.,Hutchins R.D.,Nirschl D.S.,Van Kirk K.,Cooper C.B.,Sutton J.C.,Ma Z.,Golla R.,Seethala R.,Salyan M.E.K.,Nayeem A.,Krystek S.R. Jr.,Sheriff S.,Camac D.M.,Morin P.E.,Carpenter B.,Robl J.A.,Zahler R.,Gordon D.A.,Hamann L.G.

Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

Bioorg. Med. Chem. Lett.

18

3168-3172

2008

1049923

Hale C.,Veniant M.,Wang Z.,Chen M.,McCormick J.,Cupples R.,Hickman D.,Min X.,Sudom A.,Xu H.,Matsumoto G.,Fotsch C.,St Jean D.J. Jr.,Wang M.

Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.

Chem. Biol. Drug Des.

71

36-44

2008

1049924

Julian L.D.,Wang Z.,Bostick T.,Caille S.,Choi R.,DeGraffenreid M.,Di Y.,He X.,Hungate R.W.,Jaen J.C.,Liu J.,Monshouwer M.,McMinn D.,Rew Y.,Sudom A.,Sun D.,Tu H.,Ursu S.,Walker N.,Yan X.,Ye Q.,Powers J.P.

Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.

J. Med. Chem.

51

3953-3960

2008

1049925

Rew Y.,McMinn D.L.,Wang Z.,He X.,Hungate R.W.,Jaen J.C.,Sudom A.,Sun D.,Tu H.,Ursu S.,Villemure E.,Walker N.P.C.,Yan X.,Ye Q.,Powers J.P.

Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.

Bioorg. Med. Chem. Lett.

19

1797-1801

2009

1049926

Sjoeblom T.,Jones S.,Wood L.D.,Parsons D.W.,Lin J.,Barber T.D.,Mandelker D.,Leary R.J.,Ptak J.,Silliman N.,Szabo S.,Buckhaults P.,Farrell C.,Meeh P.,Markowitz S.D.,Willis J.,Dawson D.,Willson J.K.V.,Gazdar A.F.,Hartigan J.,Wu L.,Liu C.,Parmigiani G.,Park B.H.,Bachman K.E.,Papadopoulos N.,Vogelstein B.,Kinzler K.W.,Velculescu V.E.

The consensus coding sequences of human breast and colorectal cancers.

Science

314

268-274

2006