Sequence of DHI1_CAVPO
EC Number:1.1.1.146
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+
Other sequences found for EC No. 1.1.1.146
General information:
Sequence
0 MAFLKKYLLT ILMVFLAYYY YSANEKFRPE MLQGKKVIVT GASKGIGREI AYHLAKMGAH
60 VVVTARSKEA LQKVVARCLE LGAASAHYIA GSMEDMTFAE EFVAEAGNLM GGLDMLILNH
120 VLYNRLTFFH GEIDNVRKSM EVNFHSFVVL SVAAMPMLMQ SQGSIAVVSS VAGKITYPLI
180 APYSASKFAL DGFFSTLRSE FLVNKVNVSI TLCILGLIDT ETAIKATSGI YLGPASPKEE
240 CALEIIKGTA LRQDEMYYVG SRWVPYLLGN PGRKIMEFLS AAEYNWDNVL SNEKLYGRWA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1049893
Pu X.,Yang K.
Guinea pig 11beta-hydroxysteroid dehydrogenase type 1: primary structure and catalytic properties.
Steroids
65
148-156
2000
1049895
Lawson A.J.,Walker E.A.,White S.A.,Dafforn T.R.,Stewart P.M.,Ride J.P.
Mutations of key hydrophobic surface residues of 11 beta-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system.
Protein Sci.
18
1552-1563
2009
1049896
Ogg D.,Elleby B.,Norstroem C.,Stefansson K.,Abrahmsen L.,Oppermann U.,Svensson S.
The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions.
J. Biol. Chem.
280
3789-3794
2005
1049897
Siu M.,Johnson T.O.,Wang Y.,Nair S.K.,Taylor W.D.,Cripps S.J.,Matthews J.J.,Edwards M.P.,Pauly T.A.,Ermolieff J.,Castro A.,Hosea N.A.,LaPaglia A.,Fanjul A.N.,Vogel J.E.
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275.
Bioorg. Med. Chem. Lett.
19
3493-3497
2009
