Sequence of CERS3_HUMAN
EC Number:2.3.1.298
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
an ultra-long-chain fatty acyl-CoA + a sphingoid base = an ultra-long-chain ceramide + CoA
Other sequences found for EC No. 2.3.1.298
General information:
Sequence
0 MFWTFKEWFW LERFWLPPTI KWSDLEDHDG LVFVKPSHLY VTIPYAFLLL IIRRVFEKFV
60 ASPLAKSFGI KETVRKVTPN TVLENFFKHS TRQPLQTDIY GLAKKCNLTE RQVERWFRSR
120 RNQERPSRLK KFQEACWRFA FYLMITVAGI AFLYDKPWLY DLWEVWNGYP KQPLLPSQYW
180 YYILEMSFYW SLLFRLGFDV KRKDFLAHII HHLAAISLMS FSWCANYIRS GTLVMIVHDV
240 ADIWLESAKM FSYAGWTQTC NTLFFIFSTI FFISRLIVFP FWILYCTLIL PMYHLEPFFS
300 YIFLNLQLMI LQVLHLYWGY YILKMLNRCI FMKSIQDVRS DDEDYEEEEE EEEEEATKGK
360 EMDCLKNGLR AERHLIPNGQ HGH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1039988
Zody M.C.,Garber M.,Sharpe T.,Young S.K.,Rowen L.,O'Neill K.,Whittaker C.A.,Kamal M.,Chang J.L.,Cuomo C.A.,Dewar K.,FitzGerald M.G.,Kodira C.D.,Madan A.,Qin S.,Yang X.,Abbasi N.,Abouelleil A.,Arachchi H.M.,Baradarani L.,Birditt B.,Bloom S.,Bloom T.,Borowsky M.L.,Burke J.,Butler J.,Cook A.,DeArellano K.,DeCaprio D.,Dorris L. III,Dors M.,Eichler E.E.,Engels R.,Fahey J.,Fleetwood P.,Friedman C.,Gearin G.,Hall J.L.,Hensley G.,Johnson E.,Jones C.,Kamat A.,Kaur A.,Locke D.P.,Madan A.,Munson G.,Jaffe D.B.,Lui A.,Macdonald P.,Mauceli E.,Naylor J.W.,Nesbitt R.,Nicol R.,O'Leary S.B.,Ratcliffe A.,Rounsley S.,She X.,Sneddon K.M.B.,Stewart S.,Sougnez C.,Stone S.M.,Topham K.,Vincent D.,Wang S.,Zimmer A.R.,Birren B.W.,Hood L.,Lander E.S.,Nusbaum C.
Analysis of the DNA sequence and duplication history of human chromosome 15.
Nature
440
671-675
2006
1039989
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1039990
Lahiri S.,Lee H.,Mesicek J.,Fuks Z.,Haimovitz-Friedman A.,Kolesnick R.N.,Futerman A.H.
Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.
FEBS Lett.
581
5289-5294
2007
1039991
Jennemann R.,Rabionet M.,Gorgas K.,Epstein S.,Dalpke A.,Rothermel U.,Bayerle A.,van der Hoeven F.,Imgrund S.,Kirsch J.,Nickel W.,Willecke K.,Riezman H.,Groene H.J.,Sandhoff R.
Loss of ceramide synthase 3 causes lethal skin barrier disruption.
Hum. Mol. Genet.
21
586-608
2012
1039992
Radner F.P.,Marrakchi S.,Kirchmeier P.,Kim G.J.,Ribierre F.,Kamoun B.,Abid L.,Leipoldt M.,Turki H.,Schempp W.,Heilig R.,Lathrop M.,Fischer J.
Mutations in CERS3 cause autosomal recessive congenital ichthyosis in humans.
PLoS Genet.
9
0-0
2013
1039993
Sassa T.,Hirayama T.,Kihara A.
Enzyme activities of the ceramide synthases CERS2-6 are regulated by phosphorylation in the C-terminal region.
J. Biol. Chem.
291
7477-7487
2016
