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Sequence of CERS2_MOUSE

EC Number:2.3.1.24

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
sphingosine N-acyltransferase
Q924Z4
Mus musculus
380
45024
Reaction
an acyl-CoA + sphingosine = CoA + a ceramide
Other sequences found for EC No. 2.3.1.24

General information:

Sequence
show sequence in fasta format
  0 MLQTLYDYFW WERLWLPVNL TWADLEDKDG RVYAKASDLY ITLPLALLFL VIRYFFELYV
 60 ATPLAALLNV KEKTRLRAPP NATLEHFYQT SGKQPKQVEV DLLSRQSGLS GRQVERWFRR
120 RRNQDRPSLL KKFREASWRF TYYLIAFVAG MAVTVDKPWF YDLRKVWEGY PIQSIIPSQY
180 WYYMIELSFY WSLLFSIASD VKRKDFKEQI IHHVATIILL CFSWFANYVR AGTLIMALHD
240 ASDYLLESAK MFNYAGWKNT CNNLFIVFAI VFIITRLVIM PFWILHCTMI YPLELYPAFF
300 GYYFFNFMMA VLQMLHIFWA YFILRMAHKF ITGKLIEDER SDREETESSE GEETAAGAGA
360 KSRLLANGHP ILNNNHPKND
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1039978
Carninci P.,Kasukawa T.,Katayama S.,Gough J.,Frith M.C.,Maeda N.,Oyama R.,Ravasi T.,Lenhard B.,Wells C.,Kodzius R.,Shimokawa K.,Bajic V.B.,Brenner S.E.,Batalov S.,Forrest A.R.,Zavolan M.,Davis M.J.,Wilming L.G.,Aidinis V.,Allen J.E.,Ambesi-Impiombato A.,Apweiler R.,Aturaliya R.N.,Bailey T.L.,Bansal M.,Baxter L.,Beisel K.W.,Bersano T.,Bono H.,Chalk A.M.,Chiu K.P.,Choudhary V.,Christoffels A.,Clutterbuck D.R.,Crowe M.L.,Dalla E.,Dalrymple B.P.,de Bono B.,Della Gatta G.,di Bernardo D.,Down T.,Engstrom P.,Fagiolini M.,Faulkner G.,Fletcher C.F.,Fukushima T.,Furuno M.,Futaki S.,Gariboldi M.,Georgii-Hemming P.,Gingeras T.R.,Gojobori T.,Green R.E.,Gustincich S.,Harbers M.,Hayashi Y.,Hensch T.K.,Hirokawa N.,Hill D.,Huminiecki L.,Iacono M.,Ikeo K.,Iwama A.,Ishikawa T.,Jakt M.,Kanapin A.,Katoh M.,Kawasawa Y.,Kelso J.,Kitamura H.,Kitano H.,Kollias G.,Krishnan S.P.,Kruger A.,Kummerfeld S.K.,Kurochkin I.V.,Lareau L.F.,Lazarevic D.,Lipovich L.,Liu J.,Liuni S.,McWilliam S.,Madan Babu M.,Madera M.,Marchionni L.,Matsuda H.,Matsuzawa S.,Miki H.,Mignone F.,Miyake S.,Morris K.,Mottagui-Tabar S.,Mulder N.,Nakano N.,Nakauchi H.,Ng P.,Nilsson R.,Nishiguchi S.,Nishikawa S.,Nori F.,Ohara O.,Okazaki Y.,Orlando V.,Pang K.C.,Pavan W.J.,Pavesi G.,Pesole G.,Petrovsky N.,Piazza S.,Reed J.,Reid J.F.,Ring B.Z.,Ringwald M.,Rost B.,Ruan Y.,Salzberg S.L.,Sandelin A.,Schneider C.,Schoenbach C.,Sekiguchi K.,Semple C.A.,Seno S.,Sessa L.,Sheng Y.,Shibata Y.,Shimada H.,Shimada K.,Silva D.,Sinclair B.,Sperling S.,Stupka E.,Sugiura K.,Sultana R.,Takenaka Y.,Taki K.,Tammoja K.,Tan S.L.,Tang S.,Taylor M.S.,Tegner J.,Teichmann S.A.,Ueda H.R.,van Nimwegen E.,Verardo R.,Wei C.L.,Yagi K.,Yamanishi H.,Zabarovsky E.,Zhu S.,Zimmer A.,Hide W.,Bult C.,Grimmond S.M.,Teasdale R.D.,Liu E.T.,Brusic V.,Quackenbush J.,Wahlestedt C.,Mattick J.S.,Hume D.A.,Kai C.,Sasaki D.,Tomaru Y.,Fukuda S.,Kanamori-Katayama M.,Suzuki M.,Aoki J.,Arakawa T.,Iida J.,Imamura K.,Itoh M.,Kato T.,Kawaji H.,Kawagashira N.,Kawashima T.,Kojima M.,Kondo S.,Konno H.,Nakano K.,Ninomiya N.,Nishio T.,Okada M.,Plessy C.,Shibata K.,Shiraki T.,Suzuki S.,Tagami M.,Waki K.,Watahiki A.,Okamura-Oho Y.,Suzuki H.,Kawai J.,Hayashizaki Y.
The transcriptional landscape of the mammalian genome.
Science
309
1559-1563
2005
1039979
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1039980
Mizutani Y.,Kihara A.,Igarashi Y.
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.
Biochem. J.
390
263-271
2005
1039981
Laviad E.L.,Albee L.,Pankova-Kholmyansky I.,Epstein S.,Park H.,Merrill A.H. Jr.,Futerman A.H.
Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate.
J. Biol. Chem.
283
5677-5684
2008
1039982
Imgrund S.,Hartmann D.,Farwanah H.,Eckhardt M.,Sandhoff R.,Degen J.,Gieselmann V.,Sandhoff K.,Willecke K.
Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas.
J. Biol. Chem.
284
33549-33560
2009
1039983
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
1039984
Pewzner-Jung Y.,Park H.,Laviad E.L.,Silva L.C.,Lahiri S.,Stiban J.,Erez-Roman R.,Bruegger B.,Sachsenheimer T.,Wieland F.,Prieto M.,Merrill A.H. Jr.,Futerman A.H.
A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways.
J. Biol. Chem.
285
10902-10910
2010
1039985
Yamashita-Sugahara Y.,Tokuzawa Y.,Nakachi Y.,Kanesaki-Yatsuka Y.,Matsumoto M.,Mizuno Y.,Okazaki Y.
Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor gamma target gene that regulates adipogenesis through ceramide synthesis.
J. Biol. Chem.
288
4522-4537
2013
1039986
Novgorodov S.A.,Riley C.L.,Keffler J.A.,Yu J.,Kindy M.S.,Macklin W.B.,Lombard D.B.,Gudz T.I.
SIRT3 deacetylates ceramide synthases: Implications for mitochondrial dysfunction and brain injury.
J. Biol. Chem.
291
1957-1973
2016
1039987
Yang Y.,Yang X.,Lin Y.,Yang G.,Li L.
LASS2 regulates hepatocyte steatosis by interacting with NDUFS2/OXPHOS related proteins.
Biochem. Biophys. Res. Commun.
526
871-879
2020