Sequence of RPB1_HUMAN
EC Number:2.7.7.48
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
nucleoside triphosphate + RNAn = diphosphate + RNAn+1
Other sequences found for EC No. 2.7.7.48
General information:
Sequence
0 MHGGGPPSGD SACPLRTIKR VQFGVLSPDE LKRMSVTEGG IKYPETTEGG RPKLGGLMDP
60 RQGVIERTGR CQTCAGNMTE CPGHFGHIEL AKPVFHVGFL VKTMKVLRCV CFFCSKLLVD
120 SNNPKIKDIL AKSKGQPKKR LTHVYDLCKG KNICEGGEEM DNKFGVEQPE GDEDLTKEKG
180 HGGCGRYQPR IRRSGLELYA EWKHVNEDSQ EKKILLSPER VHEIFKRISD EECFVLGMEP
240 RYARPEWMIV TVLPVPPLSV RPAVVMQGSA RNQDDLTHKL ADIVKINNQL RRNEQNGAAA
300 HVIAEDVKLL QFHVATMVDN ELPGLPRAMQ KSGRPLKSLK QRLKGKEGRV RGNLMGKRVD
360 FSARTVITPD PNLSIDQVGV PRSIAANMTF AEIVTPFNID RLQELVRRGN SQYPGAKYII
420 RDNGDRIDLR FHPKPSDLHL QTGYKVERHM CDGDIVIFNR QPTLHKMSMM GHRVRILPWS
480 TFRLNLSVTT PYNADFDGDE MNLHLPQSLE TRAEIQELAM VPRMIVTPQS NRPVMGIVQD
540 TLTAVRKFTK RDVFLERGEV MNLLMFLSTW DGKVPQPAIL KPRPLWTGKQ IFSLIIPGHI
600 NCIRTHSTHP DDEDSGPYKH ISPGDTKVVV ENGELIMGIL CKKSLGTSAG SLVHISYLEM
660 GHDITRLFYS NIQTVINNWL LIEGHTIGIG DSIADSKTYQ DIQNTIKKAK QDVIEVIEKA
720 HNNELEPTPG NTLRQTFENQ VNRILNDARD KTGSSAQKSL SEYNNFKSMV VSGAKGSKIN
780 ISQVIAVVGQ QNVEGKRIPF GFKHRTLPHF IKDDYGPESR GFVENSYLAG LTPTEFFFHA
840 MGGREGLIDT AVKTAETGYI QRRLIKSMES VMVKYDATVR NSINQVVQLR YGEDGLAGES
900 VEFQNLATLK PSNKAFEKKF RFDYTNERAL RRTLQEDLVK DVLSNAHIQN ELEREFERMR
960 EDREVLRVIF PTGDSKVVLP CNLLRMIWNA QKIFHINPRL PSDLHPIKVV EGVKELSKKL
1020 VIVNGDDPLS RQAQENATLL FNIHLRSTLC SRRMAEEFRL SGEAFDWLLG EIESKFNQAI
1080 AHPGEMVGAL AAQSLGEPAT QMTLNTFHYA GVSAKNVTLG VPRLKELINI SKKPKTPSLT
1140 VFLLGQSARD AERAKDILCR LEHTTLRKVT ANTAIYYDPN PQSTVVAEDQ EWVNVYYEMP
1200 DFDVARISPW LLRVELDRKH MTDRKLTMEQ IAEKINAGFG DDLNCIFNDD NAEKLVLRIR
1260 IMNSDENKMQ EEEEVVDKMD DDVFLRCIES NMLTDMTLQG IEQISKVYMH LPQTDNKKKI
1320 IITEDGEFKA LQEWILETDG VSLMRVLSEK DVDPVRTTSN DIVEIFTVLG IEAVRKALER
1380 ELYHVISFDG SYVNYRHLAL LCDTMTCRGH LMAITRHGVN RQDTGPLMKC SFEETVDVLM
1440 EAAAHGESDP MKGVSENIML GQLAPAGTGC FDLLLDAEKC KYGMEIPTNI PGLGAAGPTG
1500 MFFGSAPSPM GGISPAMTPW NQGATPAYGA WSPSVGSGMT PGAAGFSPSA ASDASGFSPG
1560 YSPAWSPTPG SPGSPGPSSP YIPSPGGAMS PSYSPTSPAY EPRSPGGYTP QSPSYSPTSP
1620 SYSPTSPSYS PTSPNYSPTS PSYSPTSPSY SPTSPSYSPT SPSYSPTSPS YSPTSPSYSP
1680 TSPSYSPTSP SYSPTSPSYS PTSPSYSPTS PSYSPTSPSY SPTSPSYSPT SPSYSPTSPS
1740 YSPTSPNYSP TSPNYTPTSP SYSPTSPSYS PTSPNYTPTS PNYSPTSPSY SPTSPSYSPT
1800 SPSYSPSSPR YTPQSPTYTP SSPSYSPSSP SYSPASPKYT PTSPSYSPSS PEYTPTSPKY
1860 SPTSPKYSPT SPKYSPTSPT YSPTTPKYSP TSPTYSPTSP VYTPTSPKYS PTSPTYSPTS
1920 PKYSPTSPTY SPTSPKGSTY SPTSPGYSPT SPTYSLTSPA ISPDDSDEEN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
91446
Wintzerith M.,Acker J.,Vicaire S.,Vigneron M.,Kedinger C.
Complete sequence of the human RNA polymerase II largest subunit.
Nucleic Acids Res.
20
910-910
1992
91447
Mita K.,Tsuji H.,Morimyo M.,Takahashi E.,Nenoi M.,Ichimura S.,Yamauchi M.,Hongo E.,Hayashi A.
The human gene encoding the largest subunit of RNA polymerase II.
Gene
159
285-286
1995
91448
Zody M.C.,Garber M.,Adams D.J.,Sharpe T.,Harrow J.,Lupski J.R.,Nicholson C.,Searle S.M.,Wilming L.,Young S.K.,Abouelleil A.,Allen N.R.,Bi W.,Bloom T.,Borowsky M.L.,Bugalter B.E.,Butler J.,Chang J.L.,Chen C.-K.,Cook A.,Corum B.,Cuomo C.A.,de Jong P.J.,DeCaprio D.,Dewar K.,FitzGerald M.,Gilbert J.,Gibson R.,Gnerre S.,Goldstein S.,Grafham D.V.,Grocock R.,Hafez N.,Hagopian D.S.,Hart E.,Norman C.H.,Humphray S.,Jaffe D.B.,Jones M.,Kamal M.,Khodiyar V.K.,LaButti K.,Laird G.,Lehoczky J.,Liu X.,Lokyitsang T.,Loveland J.,Lui A.,Macdonald P.,Major J.E.,Matthews L.,Mauceli E.,McCarroll S.A.,Mihalev A.H.,Mudge J.,Nguyen C.,Nicol R.,O'Leary S.B.,Osoegawa K.,Schwartz D.C.,Shaw-Smith C.,Stankiewicz P.,Steward C.,Swarbreck D.,Venkataraman V.,Whittaker C.A.,Yang X.,Zimmer A.R.,Bradley A.,Hubbard T.,Birren B.W.,Rogers J.,Lander E.S.,Nusbaum C.
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Nature
440
1045-1049
2006
91450
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
91451
Kershnar E.,Wu S.-Y.,Chiang C.-M.
Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.
J. Biol. Chem.
273
34444-34453
1998
91452
Nayler O.,Straetling W.,Bourquin J.-P.,Stagljar I.,Lindemann L.,Jasper H.,Hartmann A.M.,Fackelmeyer F.O.,Ullrich A.,Stamm S.
SAF-B couples transcription and pre-mRNA splicing to SAR/MAR elements.
Nucleic Acids Res.
26
3542-3549
1998
91453
Parada C.A.,Roeder R.G.
A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.
EMBO J.
18
3688-3701
1999
91454
Kim J.B.,Yamaguchi Y.,Wada T.,Handa H.,Sharp P.A.
Tat-SF1 protein associates with RAP30 and human SPT5 proteins.
Mol. Cell. Biol.
19
5960-5968
1999
91455
Allen M.,Friedler A.,Schon O.,Bycroft M.
The structure of an FF domain from human HYPA/FBP11.
J. Mol. Biol.
323
411-416
2002
91456
Carty S.M.,Greenleaf A.L.
Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing.
Mol. Cell. Proteomics
1
598-610
2002
91457
Rossow K.L.,Janknecht R.
Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300.
Oncogene
22
151-156
2003
91458
Brill L.M.,Salomon A.R.,Ficarro S.B.,Mukherji M.,Stettler-Gill M.,Peters E.C.
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
Anal. Chem.
76
2763-2772
2004
91459
Kurosu T.,Zhang F.,Peterlin B.M.
Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb.
Gene
343
173-179
2004
91460
Yang L.,Li N.,Wang C.,Yu Y.,Yuan L.,Zhang M.,Cao X.
Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells.
J. Biol. Chem.
279
11639-11648
2004
91461
Hughes C.M.,Rozenblatt-Rosen O.,Milne T.A.,Copeland T.D.,Levine S.S.,Lee J.C.,Hayes D.N.,Shanmugam K.S.,Bhattacharjee A.,Biondi C.A.,Kay G.F.,Hayward N.K.,Hess J.L.,Meyerson M.
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.
Mol. Cell
13
587-597
2004
91462
Katsarou M.E.,Papakyriakou A.,Katsaros N.,Scorilas A.
Expression of the C-terminal domain of novel human SR-A1 protein: interaction with the CTD domain of RNA polymerase II.
Biochem. Biophys. Res. Commun.
334
61-68
2005
91463
Sun X.-J.,Wei J.,Wu X.-Y.,Hu M.,Wang L.,Wang H.-H.,Zhang Q.-H.,Chen S.-J.,Huang Q.-H.,Chen Z.
Identification and characterization of a novel human histone H3 lysine 36 specific methyltransferase.
J. Biol. Chem.
280
35261-35271
2005
91464
Li M.,Phatnani H.P.,Guan Z.,Sage H.,Greenleaf A.L.,Zhou P.
Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1.
Proc. Natl. Acad. Sci. U.S.A.
102
17636-17641
2005
91465
Beausoleil S.A.,Villen J.,Gerber S.A.,Rush J.,Gygi S.P.
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Nat. Biotechnol.
24
1285-1292
2006
91466
Moniaux N.,Nemos C.,Schmied B.M.,Chauhan S.C.,Deb S.,Morikane K.,Choudhury A.,Vanlith M.,Sutherlin M.,Sikela J.M.,Hollingsworth M.A.,Batra S.K.
The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis.
Oncogene
25
3247-3257
2006
91467
Yoh S.M.,Cho H.,Pickle L.,Evans R.M.,Jones K.A.
The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export.
Genes Dev.
21
160-174
2007
91468
Haline-Vaz T.,Silva T.C.L.,Zanchin N.I.T.
The human interferon-regulated ISG95 protein interacts with RNA polymerase II and shows methyltransferase activity.
Biochem. Biophys. Res. Commun.
372
719-724
2008
91469
Becker R.,Loll B.,Meinhart A.
Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the carboxyl-terminal domain of RNA polymerase II.
J. Biol. Chem.
283
22659-22669
2008
91470
Chang J.,Nie X.,Chang H.E.,Han Z.,Taylor J.
Transcription of hepatitis delta virus RNA by RNA polymerase II.
J. Virol.
82
1118-1127
2008
91471
Lee J.H.,Skalnik D.G.
Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.
Mol. Cell. Biol.
28
609-618
2008
91472
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
91473
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
91474
Liu L.,Ishihara K.,Ichimura T.,Fujita N.,Hino S.,Tomita S.,Watanabe S.,Saitoh N.,Ito T.,Nakao M.
MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.
J. Biol. Chem.
284
5165-5174
2009
91475
Akhtar M.S.,Heidemann M.,Tietjen J.R.,Zhang D.W.,Chapman R.D.,Eick D.,Ansari A.Z.
TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II.
Mol. Cell
34
387-393
2009
91476
Glover-Cutter K.,Larochelle S.,Erickson B.,Zhang C.,Shokat K.,Fisher R.P.,Bentley D.L.
TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II.
Mol. Cell. Biol.
29
5455-5464
2009
91477
Lolli G.
Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation.
Nucleic Acids Res.
37
1260-1268
2009
91478
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
91479
Islam M.N.,Fox D. III,Guo R.,Enomoto T.,Wang W.
RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase.
Mol. Cell. Biol.
30
2460-2472
2010
91480
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
91481
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
91482
David C.J.,Boyne A.R.,Millhouse S.R.,Manley J.L.
The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex.
Genes Dev.
25
972-983
2011
91483
Cojocaru M.,Bouchard A.,Cloutier P.,Cooper J.J.,Varzavand K.,Price D.H.,Coulombe B.
Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B.
J. Biol. Chem.
286
5012-5022
2011
91484
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
91485
Sims R.J. III,Rojas L.A.,Beck D.,Bonasio R.,Schuller R.,Drury W.J. III,Eick D.,Reinberg D.
The C-terminal domain of RNA polymerase II is modified by site-specific methylation.
Science
332
99-103
2011
91486
Egloff S.,Zaborowska J.,Laitem C.,Kiss T.,Murphy S.
Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes.
Mol. Cell
45
111-122
2012
91487
Nakazawa Y.,Sasaki K.,Mitsutake N.,Matsuse M.,Shimada M.,Nardo T.,Takahashi Y.,Ohyama K.,Ito K.,Mishima H.,Nomura M.,Kinoshita A.,Ono S.,Takenaka K.,Masuyama R.,Kudo T.,Slor H.,Utani A.,Tateishi S.,Yamashita S.,Stefanini M.,Lehmann A.R.,Yoshiura K.I.,Ogi T.
Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair.
Nat. Genet.
44
586-592
2012
91488
Guo L.,Wu W.J.,Liu L.D.,Wang L.C.,Zhang Y.,Wu L.Q.,Guan Y.,Li Q.H.
Herpes simplex virus 1 ICP22 inhibits the transcription of viral gene promoters by binding to and blocking the recruitment of P-TEFb.
PLoS ONE
7
0-0
2012
91489
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
91490
Schroeder S.,Herker E.,Itzen F.,He D.,Thomas S.,Gilchrist D.A.,Kaehlcke K.,Cho S.,Pollard K.S.,Capra J.A.,Schnoelzer M.,Cole P.A.,Geyer M.,Bruneau B.G.,Adelman K.,Ott M.
Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells.
Mol. Cell
52
314-324
2013
91491
Yuce O.,West S.C.
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
Mol. Cell. Biol.
33
406-417
2013
91492
Singh S.K.,Maeda K.,Eid M.M.,Almofty S.A.,Ono M.,Pham P.,Goodman M.F.,Sakaguchi N.
GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.
Nat. Commun.
4
1830-1830
2013
91493
Horejsi Z.,Stach L.,Flower T.G.,Joshi D.,Flynn H.,Skehel J.M.,O'Reilly N.J.,Ogrodowicz R.W.,Smerdon S.J.,Boulton S.J.
Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.
Cell Rep.
7
19-26
2014
91494
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
91495
Dias J.D.,Rito T.,Torlai Triglia E.,Kukalev A.,Ferrai C.,Chotalia M.,Brookes E.,Kimura H.,Pombo A.
Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells.
Elife
4
0-0
2015
91496
Voss K.,Forne I.,Descostes N.,Hintermair C.,Schueller R.,Maqbool M.A.,Heidemann M.,Flatley A.,Imhof A.,Gut M.,Gut I.,Kremmer E.,Andrau J.C.,Eick D.
Site-specific methylation and acetylation of lysine residues in the C-terminal domain (CTD) of RNA polymerase II.
Transcription
6
91-101
2015
91497
Yu Y.,Reed R.
FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP.
Proc. Natl. Acad. Sci. U.S.A.
112
8608-8613
2015
91498
Yanling Zhao D.,Gish G.,Braunschweig U.,Li Y.,Ni Z.,Schmitges F.W.,Zhong G.,Liu K.,Li W.,Moffat J.,Vedadi M.,Min J.,Pawson T.J.,Blencowe B.J.,Greenblatt J.F.
SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination.
Nature
529
48-53
2016
91499
Sridhara S.C.,Carvalho S.,Grosso A.R.,Gallego-Paez L.M.,Carmo-Fonseca M.,de Almeida S.F.
Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation.
Cell Rep.
18
334-343
2017
91500
Zhang Y.,Kim Y.,Genoud N.,Gao J.,Kelly J.W.,Pfaff S.L.,Gill G.N.,Dixon J.E.,Noel J.P.
Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1.
Mol. Cell
24
759-770
2006
91501
Kassube S.A.,Jinek M.,Fang J.,Tsutakawa S.,Nogales E.
Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5.
Nat. Struct. Mol. Biol.
20
892-899
2013
91502
Haijes H.A.,Koster M.J.E.,Rehmann H.,Li D.,Hakonarson H.,Cappuccio G.,Hancarova M.,Lehalle D.,Reardon W.,Schaefer G.B.,Lehman A.,van de Laar I.M.B.H.,Tesselaar C.D.,Turner C.,Goldenberg A.,Patrier S.,Thevenon J.,Pinelli M.,Brunetti-Pierri N.,Prchalova D.,Havlovicova M.,Vlckova M.,Sedlacek Z.,Lopez E.,Ragoussis V.,Pagnamenta A.T.,Kini U.,Vos H.R.,van Es R.M.,van Schaik R.F.M.A.,van Essen T.A.J.,Kibaek M.,Taylor J.C.,Sullivan J.,Shashi V.,Petrovski S.,Fagerberg C.,Martin D.M.,van Gassen K.L.I.,Pfundt R.,Falk M.J.,McCormick E.M.,Timmers H.T.M.,van Hasselt P.M.
De Novo Heterozygous POLR2A Variants Cause a Neurodevelopmental Syndrome with Profound Infantile-Onset Hypotonia.
Am. J. Hum. Genet.
105
283-301
2019
