Sequence of TPSDV_ABIGR
EC Number:4.2.3.132
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
(+)-copalyl diphosphate = neoabietadiene + diphosphate
Other sequences found for EC No. 4.2.3.132
General information:
Sequence
0 MAMPSSSLSS QIPTAAHHLT ANAQSIPHFS TTLNAGSSAS KRRSLYLRWG KGSNKIIACV
60 GEGGATSVPY QSAEKNDSLS SSTLVKREFP PGFWKDDLID SLTSSHKVAA SDEKRIETLI
120 SEIKNMFRCM GYGETNPSAY DTAWVARIPA VDGSDNPHFP ETVEWILQNQ LKDGSWGEGF
180 YFLAYDRILA TLACIITLTL WRTGETQVQK GIEFFRTQAG KMEDEADSHR PSGFEIVFPA
240 MLKEAKILGL DLPYDLPFLK QIIEKREAKL KRIPTDVLYA LPTTLLYSLE GLQEIVDWQK
300 IMKLQSKDGS FLSSPASTAA VFMRTGNKKC LDFLNFVLKK FGNHVPCHYP LDLFERLWAV
360 DTVERLGIDR HFKEEIKEAL DYVYSHWDER GIGWARENPV PDIDDTAMGL RILRLHGYNV
420 SSDVLKTFRD ENGEFFCFLG QTQRGVTDML NVNRCSHVSF PGETIMEEAK LCTERYLRNA
480 LENVDAFDKW AFKKNIRGEV EYALKYPWHK SMPRLEARSY IENYGPDDVW LGKTVYMMPY
540 ISNEKYLELA KLDFNKVQSI HQTELQDLRR WWKSSGFTDL NFTRERVTEI YFSPASFIFE
600 PEFSKCREVY TKTSNFTVIL DDLYDAHGSL DDLKLFTESV KRWDLSLVDQ MPQQMKICFV
660 GFYNTFNDIA KEGRERQGRD VLGYIQNVWK VQLEAYTKEA EWSEAKYVPS FNEYIENASV
720 SIALGTVVLI SALFTGEVLT DEVLSKIDRE SRFLQLMGLT GRLVNDTKTY QAERGQGEVA
780 SAIQCYMKDH PKISEEEALQ HVYSVMENAL EELNREFVNN KIPDIYKRLV FETARIMQLF
840 YMQGDGLTLS HDMEIKEHVK NCLFQPVA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1008109
Stoffer Vogel B.,Wildung M.R.,Vogel G.,Croteau R.B.
Abietadiene synthase from grand fir (Abies grandis). cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase involved in resin acid biosynthesis.
J. Biol. Chem.
271
23262-23268
1996
1008110
Trapp S.C.,Croteau R.B.
Genomic organization of plant terpene synthases and molecular evolutionary implications.
Genetics
158
811-832
2001
1008111
Bohlmann J.,Meyer-Gauen G.,Croteau R.B.
Plant terpenoid synthases: molecular biology and phylogenetic analysis.
Proc. Natl. Acad. Sci. U.S.A.
95
4126-4133
1998
1008112
Peters R.J.,Flory J.E.,Jetter R.,Ravn M.M.,Lee H.J.,Coates R.M.,Croteau R.B.
Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the 'pseudomature' recombinant enzyme.
Biochemistry
39
15592-15602
2000
1008113
Ravn M.M.,Coates R.M.,Flory J.E.,Peters R.J.,Croteau R.
Stereochemistry of the cyclization-rearrangement of (+)-copalyl diphosphate to (-)-abietadiene catalyzed by recombinant abietadiene synthase from Abies grandis.
Org. Lett.
2
573-576
2000
1008114
Peters R.J.,Ravn M.M.,Coates R.M.,Croteau R.B.
Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites.
J. Am. Chem. Soc.
123
8974-8978
2001
1008115
Peters R.J.,Croteau R.B.
Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate.
Biochemistry
41
1836-1842
2002
1008116
Peters R.J.,Croteau R.B.
Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement.
Proc. Natl. Acad. Sci. U.S.A.
99
580-584
2002
1008117
Peters R.J.,Carter O.A.,Zhang Y.,Matthews B.W.,Croteau R.B.
Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations.
Biochemistry
42
2700-2707
2003
1008118
Wilderman P.R.,Peters R.J.
A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase.
J. Am. Chem. Soc.
129
15736-15737
2007
1008119
Mann F.M.,Prisic S.,Davenport E.K.,Determan M.K.,Coates R.M.,Peters R.J.
A single residue switch for Mg(2+)-dependent inhibition characterizes plant class II diterpene cyclases from primary and secondary metabolism.
J. Biol. Chem.
285
20558-20563
2010
1008120
Zhou K.,Gao Y.,Hoy J.A.,Mann F.M.,Honzatko R.B.,Peters R.J.
Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis.
J. Biol. Chem.
287
6840-6850
2012
