Sequence of RNF31_HUMAN
EC Number:2.3.2.31
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine
Other sequences found for EC No. 2.3.2.31
General information:
Sequence
0 MPGEEEERAF LVAREELASA LRRDSGQAFS LEQLRPLLAS SLPLAARYLQ LDAARLVRCN
60 AHGEPRNYLN TLSTALNILE KYGRNLLSPQ RPRYWRGVKF NNPVFRSTVD AVQGGRDVLR
120 LYGYTEEQPD GLSFPEGQEE PDEHQVATVT LEVLLLRTEL SLLLQNTHPR QQALEQLLED
180 KVEDDMLQLS EFDPLLREIA PGPLTTPSVP GSTPGPCFLC GSAPGTLHCP SCKQALCPAC
240 DHLFHGHPSR AHHLRQTLPG VLQGTHLSPS LPASAQPRPQ STSLLALGDS SLSSPNPASA
300 HLPWHCAACA MLNEPWAVLC VACDRPRGCK GLGLGTEGPQ GTGGLEPDLA RGRWACQSCT
360 FENEAAAVLC SICERPRLAQ PPSLVVDSRD AGICLQPLQQ GDALLASAQS QVWYCIHCTF
420 CNSSPGWVCV MCNRTSSPIP AQHAPRPYAS SLEKGPPKPG PPRRLSAPLP SSCGDPEKQR
480 QDKMREEGLQ LVSMIREGEA AGACPEEIFS ALQYSGTEVP LQWLRSELPY VLEMVAELAG
540 QQDPGLGAFS CQEARRAWLD RHGNLDEAVE ECVRTRRRKV QELQSLGFGP EEGSLQALFQ
600 HGGDVSRALT ELQRQRLEPF RQRLWDSGPE PTPSWDGPDK QSLVRRLLAV YALPSWGRAE
660 LALSLLQETP RNYELGDVVE AVRHSQDRAF LRRLLAQECA VCGWALPHNR MQALTSCECT
720 ICPDCFRQHF TIALKEKHIT DMVCPACGRP DLTDDTQLLS YFSTLDIQLR ESLEPDAYAL
780 FHKKLTEGVL MRDPKFLWCA QCSFGFIYER EQLEATCPQC HQTFCVRCKR QWEEQHRGRS
840 CEDFQNWKRM NDPEYQAQGL AMYLQENGID CPKCKFSYAL ARGGCMHFHC TQCRHQFCSG
900 CYNAFYAKNK CPEPNCRVKK SLHGHHPRDC LFYLRDWTAL RLQKLLQDNN VMFNTEPPAG
960 ARAVPGGGCR VIEQKEVPNG LRDEACGKET PAGYAGLCQA HYKEYLVSLI NAHSLDPATL
1020 YEVEELETAT ERYLHVRPQP LAGEDPPAYQ ARLLQKLTEE VPLGQSIPRR RK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
987393
Thompson H.G.R.,Harris J.W.,Lin L.,Brody J.P.
Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells.
Exp. Cell Res.
295
448-459
2004
987394
Kirisako T.,Kamei K.,Murata S.,Kato M.,Fukumoto H.,Kanie M.,Sano S.,Tokunaga F.,Tanaka K.,Iwai K.
A ubiquitin ligase complex assembles linear polyubiquitin chains.
EMBO J.
25
4877-4887
2006
987395
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
987396
Heilig R.,Eckenberg R.,Petit J.-L.,Fonknechten N.,Da Silva C.,Cattolico L.,Levy M.,Barbe V.,De Berardinis V.,Ureta-Vidal A.,Pelletier E.,Vico V.,Anthouard V.,Rowen L.,Madan A.,Qin S.,Sun H.,Du H.,Pepin K.,Artiguenave F.,Robert C.,Cruaud C.,Bruels T.,Jaillon O.,Friedlander L.,Samson G.,Brottier P.,Cure S.,Segurens B.,Aniere F.,Samain S.,Crespeau H.,Abbasi N.,Aiach N.,Boscus D.,Dickhoff R.,Dors M.,Dubois I.,Friedman C.,Gouyvenoux M.,James R.,Madan A.,Mairey-Estrada B.,Mangenot S.,Martins N.,Menard M.,Oztas S.,Ratcliffe A.,Shaffer T.,Trask B.,Vacherie B.,Bellemere C.,Belser C.,Besnard-Gonnet M.,Bartol-Mavel D.,Boutard M.,Briez-Silla S.,Combette S.,Dufosse-Laurent V.,Ferron C.,Lechaplais C.,Louesse C.,Muselet D.,Magdelenat G.,Pateau E.,Petit E.,Sirvain-Trukniewicz P.,Trybou A.,Vega-Czarny N.,Bataille E.,Bluet E.,Bordelais I.,Dubois M.,Dumont C.,Guerin T.,Haffray S.,Hammadi R.,Muanga J.,Pellouin V.,Robert D.,Wunderle E.,Gauguet G.,Roy A.,Sainte-Marthe L.,Verdier J.,Verdier-Discala C.,Hillier L.W.,Fulton L.,McPherson J.,Matsuda F.,Wilson R.,Scarpelli C.,Gyapay G.,Wincker P.,Saurin W.,Quetier F.,Waterston R.,Hood L.,Weissenbach J.
The DNA sequence and analysis of human chromosome 14.
Nature
421
601-607
2003
987398
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
987399
Jikuya H.,Takano J.,Kikuno R.,Hirosawa M.,Nagase T.,Nomura N.,Ohara O.
Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.
DNA Res.
10
49-57
2003
987400
Cantin G.T.,Yi W.,Lu B.,Park S.K.,Xu T.,Lee J.-D.,Yates J.R. III
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
J. Proteome Res.
7
1346-1351
2008
987401
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
987402
Haas T.L.,Emmerich C.H.,Gerlach B.,Schmukle A.C.,Cordier S.M.,Rieser E.,Feltham R.,Vince J.,Warnken U.,Wenger T.,Koschny R.,Komander D.,Silke J.,Walczak H.
Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.
Mol. Cell
36
831-844
2009
987403
Tokunaga F.,Sakata S.,Saeki Y.,Satomi Y.,Kirisako T.,Kamei K.,Nakagawa T.,Kato M.,Murata S.,Yamaoka S.,Yamamoto M.,Akira S.,Takao T.,Tanaka K.,Iwai K.
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.
Nat. Cell Biol.
11
123-132
2009
987404
Gerlach B.,Cordier S.M.,Schmukle A.C.,Emmerich C.H.,Rieser E.,Haas T.L.,Webb A.I.,Rickard J.A.,Anderton H.,Wong W.W.,Nachbur U.,Gangoda L.,Warnken U.,Purcell A.W.,Silke J.,Walczak H.
Linear ubiquitination prevents inflammation and regulates immune signalling.
Nature
471
591-596
2011
987405
Tokunaga F.,Nakagawa T.,Nakahara M.,Saeki Y.,Taniguchi M.,Sakata S.,Tanaka K.,Nakano H.,Iwai K.
SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex.
Nature
471
633-636
2011
987406
Ikeda F.,Deribe Y.L.,Skanland S.S.,Stieglitz B.,Grabbe C.,Franz-Wachtel M.,van Wijk S.J.,Goswami P.,Nagy V.,Terzic J.,Tokunaga F.,Androulidaki A.,Nakagawa T.,Pasparakis M.,Iwai K.,Sundberg J.P.,Schaefer L.,Rittinger K.,Macek B.,Dikic I.
SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis.
Nature
471
637-641
2011
987407
Smit J.J.,Monteferrario D.,Noordermeer S.M.,van Dijk W.J.,van der Reijden B.A.,Sixma T.K.
The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.
EMBO J.
31
3833-3844
2012
987408
Yagi H.,Ishimoto K.,Hiromoto T.,Fujita H.,Mizushima T.,Uekusa Y.,Yagi-Utsumi M.,Kurimoto E.,Noda M.,Uchiyama S.,Tokunaga F.,Iwai K.,Kato K.
A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex.
EMBO Rep.
13
462-468
2012
987409
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
987410
Rivkin E.,Almeida S.M.,Ceccarelli D.F.,Juang Y.C.,Maclean T.A.,Srikumar T.,Huang H.,Dunham W.H.,Fukumura R.,Xie G.,Gondo Y.,Raught B.,Gingras A.C.,Sicheri F.,Cordes S.P.
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
Nature
498
318-324
2013
987411
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
987412
Schlicher L.,Wissler M.,Preiss F.,Brauns-Schubert P.,Jakob C.,Dumit V.,Borner C.,Dengjel J.,Maurer U.
SPATA2 promotes CYLD activity and regulates TNF-induced NF-kappaB signaling and cell death.
EMBO Rep.
17
1485-1497
2016
987413
Kupka S.,De Miguel D.,Draber P.,Martino L.,Surinova S.,Rittinger K.,Walczak H.
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
Cell Rep.
16
2271-2280
2016
987414
Hrdinka M.,Fiil B.K.,Zucca M.,Leske D.,Bagola K.,Yabal M.,Elliott P.R.,Damgaard R.B.,Komander D.,Jost P.J.,Gyrd-Hansen M.
CYLD limits Lys63- and Met1-linked ubiquitin at receptor complexes to regulate innate immune signaling.
Cell Rep.
14
2846-2858
2016
987415
Yang Y.K.,Yang C.,Chan W.,Wang Z.,Deibel K.E.,Pomerantz J.L.
Molecular determinants of scaffold-induced linear ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T cell receptor and oncogenic caspase recruitment domain-containing protein 11 (CARD11) signaling.
J. Biol. Chem.
291
25921-25936
2016
987416
de Jong M.F.,Liu Z.,Chen D.,Alto N.M.
Shigella flexneri suppresses NF-kappaB activation by inhibiting linear ubiquitin chain ligation.
Nat. Microbiol.
1
16084-16084
2016
987417
Noad J.,von der Malsburg A.,Pathe C.,Michel M.A.,Komander D.,Randow F.
LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-kappaB.
Nat. Microbiol.
2
17063-17063
2017
987418
Goto E.,Tokunaga F.
Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP.
Biochem. Biophys. Res. Commun.
485
152-159
2017
987419
Otten E.G.,Werner E.,Crespillo-Casado A.,Boyle K.B.,Dharamdasani V.,Pathe C.,Santhanam B.,Randow F.
Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection.
Nature
594
111-116
2021
987421
Elliott P.R.,Nielsen S.V.,Marco-Casanova P.,Fiil B.K.,Keusekotten K.,Mailand N.,Freund S.M.,Gyrd-Hansen M.,Komander D.
Molecular basis and regulation of OTULIN-LUBAC interaction.
Mol. Cell
54
335-348
2014
987422
Schaeffer V.,Akutsu M.,Olma M.H.,Gomes L.C.,Kawasaki M.,Dikic I.
Binding of OTULIN to the PUB domain of HOIP controls NF-kappaB signaling.
Mol. Cell
54
349-361
2014
987423
Elliott P.R.,Leske D.,Hrdinka M.,Bagola K.,Fiil B.K.,McLaughlin S.H.,Wagstaff J.,Volkmar N.,Christianson J.C.,Kessler B.M.,Freund S.M.,Komander D.,Gyrd-Hansen M.
SPATA2 links CYLD to LUBAC, activates CYLD, and controls LUBAC signaling.
Mol. Cell
63
990-1005
2016
