Sequence of PTN11_MOUSE
EC Number:3.1.3.48
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
Other sequences found for EC No. 3.1.3.48
General information:
Sequence
0 MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG
60 DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK
120 EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDGKSKVTHV MIRCQELKYD
180 VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT
240 DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP
300 VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV
360 ERGKSKCVKY WPDEYALKEY GVMRVRNVKE SAAHDYTLRE LKLSKVGQGN TERTVWQYHF
420 RTWPDHGVPS DPGGVLDFLE EVHHKQESIV DAGPVVVHCS AGIGRTGTFI VIDILIDIIR
480 EKGVDCDIDV PKTIQMVRSQ RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH
540 EYTNIKYSLV DQTSGDQSPL PPCTPTPPCA EMREDSARVY ENVGLMQQQR SFR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
976769
Ohnishi H.,Kubota M.,Ohtake A.,Sato K.,Sano S.
Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule.
J. Biol. Chem.
271
25569-25574
1996
976770
Carninci P.,Kasukawa T.,Katayama S.,Gough J.,Frith M.C.,Maeda N.,Oyama R.,Ravasi T.,Lenhard B.,Wells C.,Kodzius R.,Shimokawa K.,Bajic V.B.,Brenner S.E.,Batalov S.,Forrest A.R.,Zavolan M.,Davis M.J.,Wilming L.G.,Aidinis V.,Allen J.E.,Ambesi-Impiombato A.,Apweiler R.,Aturaliya R.N.,Bailey T.L.,Bansal M.,Baxter L.,Beisel K.W.,Bersano T.,Bono H.,Chalk A.M.,Chiu K.P.,Choudhary V.,Christoffels A.,Clutterbuck D.R.,Crowe M.L.,Dalla E.,Dalrymple B.P.,de Bono B.,Della Gatta G.,di Bernardo D.,Down T.,Engstrom P.,Fagiolini M.,Faulkner G.,Fletcher C.F.,Fukushima T.,Furuno M.,Futaki S.,Gariboldi M.,Georgii-Hemming P.,Gingeras T.R.,Gojobori T.,Green R.E.,Gustincich S.,Harbers M.,Hayashi Y.,Hensch T.K.,Hirokawa N.,Hill D.,Huminiecki L.,Iacono M.,Ikeo K.,Iwama A.,Ishikawa T.,Jakt M.,Kanapin A.,Katoh M.,Kawasawa Y.,Kelso J.,Kitamura H.,Kitano H.,Kollias G.,Krishnan S.P.,Kruger A.,Kummerfeld S.K.,Kurochkin I.V.,Lareau L.F.,Lazarevic D.,Lipovich L.,Liu J.,Liuni S.,McWilliam S.,Madan Babu M.,Madera M.,Marchionni L.,Matsuda H.,Matsuzawa S.,Miki H.,Mignone F.,Miyake S.,Morris K.,Mottagui-Tabar S.,Mulder N.,Nakano N.,Nakauchi H.,Ng P.,Nilsson R.,Nishiguchi S.,Nishikawa S.,Nori F.,Ohara O.,Okazaki Y.,Orlando V.,Pang K.C.,Pavan W.J.,Pavesi G.,Pesole G.,Petrovsky N.,Piazza S.,Reed J.,Reid J.F.,Ring B.Z.,Ringwald M.,Rost B.,Ruan Y.,Salzberg S.L.,Sandelin A.,Schneider C.,Schoenbach C.,Sekiguchi K.,Semple C.A.,Seno S.,Sessa L.,Sheng Y.,Shibata Y.,Shimada H.,Shimada K.,Silva D.,Sinclair B.,Sperling S.,Stupka E.,Sugiura K.,Sultana R.,Takenaka Y.,Taki K.,Tammoja K.,Tan S.L.,Tang S.,Taylor M.S.,Tegner J.,Teichmann S.A.,Ueda H.R.,van Nimwegen E.,Verardo R.,Wei C.L.,Yagi K.,Yamanishi H.,Zabarovsky E.,Zhu S.,Zimmer A.,Hide W.,Bult C.,Grimmond S.M.,Teasdale R.D.,Liu E.T.,Brusic V.,Quackenbush J.,Wahlestedt C.,Mattick J.S.,Hume D.A.,Kai C.,Sasaki D.,Tomaru Y.,Fukuda S.,Kanamori-Katayama M.,Suzuki M.,Aoki J.,Arakawa T.,Iida J.,Imamura K.,Itoh M.,Kato T.,Kawaji H.,Kawagashira N.,Kawashima T.,Kojima M.,Kondo S.,Konno H.,Nakano K.,Ninomiya N.,Nishio T.,Okada M.,Plessy C.,Shibata K.,Shiraki T.,Suzuki S.,Tagami M.,Waki K.,Watahiki A.,Okamura-Oho Y.,Suzuki H.,Kawai J.,Hayashizaki Y.
The transcriptional landscape of the mammalian genome.
Science
309
1559-1563
2005
976771
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
976772
Feng G.-S.,Hui C.-C.,Pawson T.
SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases.
Science
259
1607-1611
1993
976773
Vogel W.,Lammers R.,Huang J.,Ullrich A.
Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation.
Science
259
1611-1614
1993
976774
Bazenet C.E.,Gelderloos J.A.,Kazlauskas A.
Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.
Mol. Cell. Biol.
16
6926-6936
1996
976775
Liu L.,Damen J.E.,Ware M.D.,Krystal G.
Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2.
J. Biol. Chem.
272
10998-11001
1997
976776
Kharitonenkov A.,Chen Z.,Sures I.,Wang H.,Schilling J.,Ullrich A.
A family of proteins that inhibit signalling through tyrosine kinase receptors.
Nature
386
181-186
1997
976777
Sattler M.,Salgia R.,Shrikhande G.,Verma S.,Choi J.-L.,Rohrschneider L.R.,Griffin J.D.
The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors.
Oncogene
15
2379-2384
1997
976778
Ito N.,Wernstedt C.,Engstrom U.,Claesson-Welsh L.
Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules.
J. Biol. Chem.
273
23410-23418
1998
976779
Kozlowski M.,Larose L.,Lee F.,Le D.M.,Rottapel R.,Siminovitch K.A.
SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain.
Mol. Cell. Biol.
18
2089-2099
1998
976780
Nishida K.,Yoshida Y.,Itoh M.,Fukada T.,Ohtani T.,Shirogane T.,Atsumi T.,Takahashi-Tezuka M.,Ishihara K.,Hibi M.,Hirano T.
Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.
Blood
93
1809-1816
1999
976781
Huber M.,Izzi L.,Grondin P.,Houde C.,Kunath T.,Veillette A.,Beauchemin N.
The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells.
J. Biol. Chem.
274
335-344
1999
976782
Lu-Kuo J.M.,Joyal D.M.,Austen K.F.,Katz H.R.
gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization.
J. Biol. Chem.
274
5791-5796
1999
976783
Jones N.,Master Z.,Jones J.,Bouchard D.,Gunji Y.,Sasaki H.,Daly R.,Alitalo K.,Dumont D.J.
Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.
J. Biol. Chem.
274
30896-30905
1999
976784
Zhang S.,Mantel C.,Broxmeyer H.E.
Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells.
J. Leukoc. Biol.
65
372-380
1999
976785
Gotoh T.,Cai D.,Tian X.,Feig L.A.,Lerner A.
p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor.
J. Biol. Chem.
275
30118-30123
2000
976786
Cross M.J.,Lu L.,Magnusson P.,Nyqvist D.,Holmqvist K.,Welsh M.,Claesson-Welsh L.
The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells.
Mol. Biol. Cell
13
2881-2893
2002
976787
Hur E.M.,Son M.,Lee O.-H.,Choi Y.B.,Park C.,Lee H.,Yun Y.
LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.
J. Exp. Med.
198
1463-1473
2003
976788
Rush J.,Moritz A.,Lee K.A.,Guo A.,Goss V.L.,Spek E.J.,Zhang H.,Zha X.-M.,Polakiewicz R.D.,Comb M.J.
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Nat. Biotechnol.
23
94-101
2005
976789
Heiss E.,Masson K.,Sundberg C.,Pedersen M.,Sun J.,Bengtsson S.,Ronnstrand L.
Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2.
Blood
108
1542-1550
2006
976790
Charest A.,Wilker E.W.,McLaughlin M.E.,Lane K.,Gowda R.,Coven S.,McMahon K.,Kovach S.,Feng Y.,Yaffe M.B.,Jacks T.,Housman D.
ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice.
Cancer Res.
66
7473-7481
2006
976791
Cao L.,Yu K.,Banh C.,Nguyen V.,Ritz A.,Raphael B.J.,Kawakami Y.,Kawakami T.,Salomon A.R.
Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
J. Immunol.
179
5864-5876
2007
976792
Ballif B.A.,Carey G.R.,Sunyaev S.R.,Gygi S.P.
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
J. Proteome Res.
7
311-318
2008
976793
Mueller M.M.,Klaile E.,Vorontsova O.,Singer B.B.,Obrink B.
Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src.
J. Cell Biol.
187
569-581
2009
976794
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
976795
Hitomi K.,Tahara-Hanaoka S.,Someya S.,Fujiki A.,Tada H.,Sugiyama T.,Shibayama S.,Shibuya K.,Shibuya A.
An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions.
Nat. Immunol.
11
601-607
2010
976796
Zhang S.Q.,Yang W.,Kontaridis M.I.,Bivona T.G.,Wen G.,Araki T.,Luo J.,Thompson J.A.,Schraven B.L.,Philips M.R.,Neel B.G.
Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment.
Mol. Cell
13
341-355
2004
976797
Mazharian A.,Wang Y.J.,Mori J.,Bem D.,Finney B.,Heising S.,Gissen P.,White J.G.,Berndt M.C.,Gardiner E.E.,Nieswandt B.,Douglas M.R.,Campbell R.D.,Watson S.P.,Senis Y.A.
Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function.
Sci. Signal.
5
0-0
2012
976798
Chen W.,Han C.,Xie B.,Hu X.,Yu Q.,Shi L.,Wang Q.,Li D.,Wang J.,Zheng P.,Liu Y.,Cao X.
Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation.
Cell
152
467-478
2013
976799
Zuo C.,Wang L.,Kamalesh R.M.,Bowen M.E.,Moore D.C.,Dooner M.S.,Reginato A.M.,Wu Q.,Schorl C.,Song Y.,Warman M.L.,Neel B.G.,Ehrlich M.G.,Yang W.
SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity.
Bone Res.
6
12-12
2018
976800
Lee C.-H.,Kominos D.,Jacques S.,Margolis B.,Schlessinger J.,Shoelson S.E.,Kuriyan J.
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Structure
2
423-438
1994
