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Sequence of PERM_HUMAN

EC Number:1.11.2.2

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
myeloperoxidase
P05164
Homo sapiens
745
83869
Reaction
Cl- + H2O2 + H+ = HClO + H2O
Other sequences found for EC No. 1.11.2.2

General information:

Sequence
show sequence in fasta format
  0 MGVPFFSSLR CMVDLGPCWA GGLTAEMKLL LALAGLLAIL ATPQPSEGAA PAVLGEVDTS
 60 LVLSSMEEAK QLVDKAYKER RESIKQRLRS GSASPMELLS YFKQPVAATR TAVRAADYLH
120 VALDLLERKL RSLWRRPFNV TDVLTPAQLN VLSKSSGCAY QDVGVTCPEQ DKYRTITGMC
180 NNRRSPTLGA SNRAFVRWLP AEYEDGFSLP YGWTPGVKRN GFPVALARAV SNEIVRFPTD
240 QLTPDQERSL MFMQWGQLLD HDLDFTPEPA ARASFVTGVN CETSCVQQPP CFPLKIPPND
300 PRIKNQADCI PFFRSCPACP GSNITIRNQI NALTSFVDAS MVYGSEEPLA RNLRNMSNQL
360 GLLAVNQRFQ DNGRALLPFD NLHDDPCLLT NRSARIPCFL AGDTRSSEMP ELTSMHTLLL
420 REHNRLATEL KSLNPRWDGE RLYQEARKIV GAMVQIITYR DYLPLVLGPT AMRKYLPTYR
480 SYNDSVDPRI ANVFTNAFRY GHTLIQPFMF RLDNRYQPME PNPRVPLSRV FFASWRVVLE
540 GGIDPILRGL MATPAKLNRQ NQIAVDEIRE RLFEQVMRIG LDLPALNMQR SRDHGLPGYN
600 AWRRFCGLPQ PETVGQLGTV LRNLKLARKL MEQYGTPNNI DIWMGGVSEP LKRKGRVGPL
660 LACIIGTQFR KLRDGDRFWW ENEGVFSMQQ RQALAQISLP RIICDNTGIT TVSKNNIFMS
720 NSYPRDFVNC STLPALNLAS WREAS
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
969715
Morishita K.,Kubota N.,Asano S.,Kaziro Y.,Nagata S.
Molecular cloning and characterization of cDNA for human myeloperoxidase.
J. Biol. Chem.
262
3844-3851
1987
969716
Morishita K.,Tsuchiya M.,Asano S.,Kaziro Y.,Nagata S.
Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor.
J. Biol. Chem.
262
15208-15213
1987
969717
Seto P.,Hirayu H.,Magnusson R.P.,Gestautas J.,Portmann L.,Degroot L.J.,Rapoport B.
Isolation of a complementary DNA clone for thyroid microsomal antigen. Homology with the gene for thyroid peroxidase.
J. Clin. Invest.
80
1205-1208
1987
969718
Johnson K.R.,Nauseef W.M.,Care A.,Wheelock M.J.,Shane S.,Hudson S.,Koeffler H.P.,Selsted M.,Miller C.,Rovera G.
Characterization of cDNA clones for human myeloperoxidase: predicted amino acid sequence and evidence for multiple mRNA species.
Nucleic Acids Res.
15
2013-2028
1987
969719
Hashinaka K.,Nishio C.,Hur S.-J.,Sakiyama F.,Tsunasawa S.,Yamada M.
Multiple species of myeloperoxidase messenger RNAs produced by alternative splicing and differential polyadenylation.
Biochemistry
27
5906-5914
1988
969721
Johnson K.R.,Gemperlein I.,Hudson S.,Shane S.,Rovera G.
Complete nucleotide sequence of the human myeloperoxidase gene.
Nucleic Acids Res.
17
7985-7986
1989
969722
Hosokawa Y.,Kawaguchi R.,Hikiji K.,Yamada M.,Suzuki K.,Nakagawa T.,Yoshihara T.,Yamaguchi K.
Cloning and characterization of four types of cDNA encoding myeloperoxidase from human monocytic leukemia cell line, SKM-1.
Leukemia
7
441-445
1993
969725
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
969726
Yamada M.,Hur S.-J.,Toda H.
Isolation and characterization of extracellular myeloperoxidase precursor in HL-60 cell cultures.
Biochem. Biophys. Res. Commun.
166
852-859
1990
969727
Van Antwerpen P.,Slomianny M.C.,Boudjeltia K.Z.,Delporte C.,Faid V.,Calay D.,Rousseau A.,Moguilevsky N.,Raes M.,Vanhamme L.,Furtmueller P.G.,Obinger C.,Vanhaeverbeek M.,Neve J.,Michalski J.C.
Glycosylation pattern of mature dimeric leukocyte and recombinant monomeric myeloperoxidase: glycosylation is required for optimal enzymatic activity.
J. Biol. Chem.
285
16351-16359
2010
969728
Taylor K.L.,Pohl J.,Kinkade J.M. Jr.
Unique autolytic cleavage of human myeloperoxidase. Implications for the involvement of active site MET409.
J. Biol. Chem.
267
25282-25288
1992
969729
Yamada M.,Yoshida M.,Hashinaka K.
Identification of transcriptional cis-elements in introns 7 and 9 of the myeloperoxidase gene.
J. Biol. Chem.
268
13479-13485
1993
969730
Yamada M.,Hur S.-J.,Hashinaka K.,Tsuneoka K.,Saeki T.,Nishio C.,Sakiyama F.,Tsunasawa S.
Isolation and characterization of a cDNA coding for human myeloperoxidase.
Arch. Biochem. Biophys.
255
147-155
1987
969731
Furtmueller P.G.,Burner U.,Obinger C.
Reaction of myeloperoxidase compound I with chloride, bromide, iodide, and thiocyanate.
Biochemistry
37
17923-17930
1998
969732
Liu T.,Qian W.-J.,Gritsenko M.A.,Camp D.G. II,Monroe M.E.,Moore R.J.,Smith R.D.
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
J. Proteome Res.
4
2070-2080
2005
969733
Ramachandran P.,Boontheung P.,Xie Y.,Sondej M.,Wong D.T.,Loo J.A.
Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.
J. Proteome Res.
5
1493-1503
2006
969734
Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
J. Proteome Res.
8
651-661
2009
969735
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
969736
Cederlund M.,Deronic A.,Pallon J.,Soerensen O.E.,Aakerstroem B.
A1M/alpha1-microglobulin is proteolytically activated by myeloperoxidase, binds its heme group and inhibits low density lipoprotein oxidation.
Front. Physiol.
6
11-11
2015
969737
Fiedler T.J.,Davey C.A.,Fenna R.E.
X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8-A resolution.
J. Biol. Chem.
275
11964-11971
2000
969738
Fenna R.E.,Zeng J.,Davey C.
Structure of the green heme in myeloperoxidase.
Arch. Biochem. Biophys.
316
653-656
1995
969739
Blair-Johnson M.,Fiedler T.,Fenna R.
Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolution.
Biochemistry
40
13990-13997
2001
969740
Kizaki M.,Miller C.W.,Selsted M.E.,Koeffler H.P.
Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency.
Blood
83
1935-1940
1994
969741
Nauseef W.M.,Brigham S.,Cogley M.
Hereditary myeloperoxidase deficiency due to a missense mutation of arginine 569 to tryptophan.
J. Biol. Chem.
269
1212-1216
1994
969742
Nauseef W.,Cogley M.,McCormick S.
Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase.
J. Biol. Chem.
271
9546-9549
1996
969743
DeLeo F.R.,Goedken M.,McCormick S.J.,Nauseef W.M.
A novel form of hereditary myeloperoxidase deficiency linked to endoplasmic reticulum/proteasome degradation.
J. Clin. Invest.
101
2900-2909
1998
969744
Romano M.,Dri P.,Dadalt L.,Patriarca P.,Baralle F.E.
Biochemical and molecular characterization of hereditary myeloperoxidase deficiency.
Blood
90
4126-4134
1997
969745
Sjoeblom T.,Jones S.,Wood L.D.,Parsons D.W.,Lin J.,Barber T.D.,Mandelker D.,Leary R.J.,Ptak J.,Silliman N.,Szabo S.,Buckhaults P.,Farrell C.,Meeh P.,Markowitz S.D.,Willis J.,Dawson D.,Willson J.K.V.,Gazdar A.F.,Hartigan J.,Wu L.,Liu C.,Parmigiani G.,Park B.H.,Bachman K.E.,Papadopoulos N.,Vogelstein B.,Kinzler K.W.,Velculescu V.E.
The consensus coding sequences of human breast and colorectal cancers.
Science
314
268-274
2006