Sequence of HSDHB_COLAA
EC Number:1.1.1.201
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
7beta-hydroxysteroid dehydrogenase (NADP+)
A4ECA9
Collinsella aerofaciens (strain ATCC 25986 / DSM 3979 / JCM 10188 / KCTC 3647 / NCTC 11838 / VPI 1003)
263
28753
Reaction
a 7beta-hydroxysteroid + NADP+ = a 7-oxosteroid + NADPH + H+
Other sequences found for EC No. 1.1.1.201
General information:
Sequence
0 MNLREKYGEW GLILGATEGV GKAFCEKIAA GGMNVVMVGR REEKLNVLAG EIRETYGVET
60 KVVRADFSQP GAAETVFAAT EGLDMGFMSY VACLHSFGKI QDTPWEKHEA MINVNVVTFL
120 KCFHHYMRIF AAQDRGAVIN VSSMTGISSS PWNGQYGAGK AFILKMTEAV ACECEGTGVD
180 VEVITLGTTL TPSLLSNLPG GPQGEAVMKI ALTPEECVDE AFEKLGKELS VIAGQRNKDS
240 VHDWKANHTE DEYIRYMGSF YRD
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
939510
Hirano S.,Masuda N.
Characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens.
Appl. Environ. Microbiol.
43
1057-1063
1982
939511
Liu L.,Aigner A.,Schmid R.D.
Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7beta-hydroxysteroid dehydrogenase from Collinsella aerofaciens.
Appl. Microbiol. Biotechnol.
90
127-135
2011
939512
Savino S.,Ferrandi E.E.,Forneris F.,Rovida S.,Riva S.,Monti D.,Mattevi A.
Structural and biochemical insights into 7beta-hydroxysteroid dehydrogenase stereoselectivity.
Proteins
84
859-865
2016
939513
Wang R.,Wu J.,Jin D.K.,Chen Y.,Lv Z.,Chen Q.,Miao Q.,Huo X.,Wang F.
Structure of NADP+-bound 7beta-hydroxysteroid dehydrogenase reveals two cofactor-binding modes.
Acta Crystallogr. F Struct. Biol. Commun.
73
246-252
2017
