Sequence of EGTD_MYCS2
EC Number:2.1.1.44
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
L-histidine Nalpha-methyltransferase
A0R5M8
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
321
35003
Reaction
3 S-adenosyl-L-methionine + L-histidine = 3 S-adenosyl-L-homocysteine + hercynine
Other sequences found for EC No. 2.1.1.44
General information:
Sequence
0 MTLSLANYLA ADSAAEALRR DVRAGLTAAP KSLPPKWFYD AVGSDLFDQI TRLPEYYPTR
60 TEAQILRTRS AEIIAAAGAD TLVELGSGTS EKTRMLLDAM RDAELLRRFI PFDVDAGVLR
120 SAGAAIGAEY PGIEIDAVCG DFEEHLGKIP HVGRRLVVFL GSTIGNLTPA PRAEFLSTLA
180 DTLQPGDSLL LGTDLVKDTG RLVRAYDDAA GVTAAFNRNV LAVVNRELSA DFDLDAFEHV
240 AKWNSDEERI EMWLRARTAQ HVRVAALDLE VDFAAGEEML TEVSCKFRPE NVVAELAEAG
300 LRQTHWWTDP AGDFGLSLAV R
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
923400
Deshayes C.,Perrodou E.,Gallien S.,Euphrasie D.,Schaeffer C.,Van-Dorsselaer A.,Poch O.,Lecompte O.,Reyrat J.-M.
Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?
Genome Biol.
8
0-0
2007
923401
Gallien S.,Perrodou E.,Carapito C.,Deshayes C.,Reyrat J.-M.,Van Dorsselaer A.,Poch O.,Schaeffer C.,Lecompte O.
Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol.
Genome Res.
19
128-135
2009
923402
Seebeck F.P.
In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.
J. Am. Chem. Soc.
132
6632-6633
2010
923403
Sao Emani C.,Williams M.J.,Wiid I.J.,Hiten N.F.,Viljoen A.J.,Pietersen R.D.,van Helden P.D.,Baker B.
Ergothioneine is a secreted antioxidant in Mycobacterium smegmatis.
Antimicrob. Agents Chemother.
57
3202-3207
2013
923404
Vit A.,Misson L.,Blankenfeldt W.,Seebeck F.P.
Crystallization and preliminary X-ray analysis of the ergothioneine-biosynthetic methyltransferase EgtD.
Acta Crystallogr. F
70
676-680
2014
923405
Jeong J.H.,Cha H.J.,Ha S.C.,Rojviriya C.,Kim Y.G.
Structural insights into the histidine trimethylation activity of EgtD from Mycobacterium smegmatis.
Biochem. Biophys. Res. Commun.
452
1098-1103
2014
923406
Vit A.,Misson L.,Blankenfeldt W.,Seebeck F.P.
Ergothioneine biosynthetic methyltransferase EgtD reveals the structural basis of aromatic amino acid betaine biosynthesis.
ChemBioChem
16
119-125
2015
