Sequence of EGT1_NEUCR
EC Number:2.1.1.44
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
L-histidine Nalpha-methyltransferase
Q7RX33
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
876
99025
Reaction
3 S-adenosyl-L-methionine + L-histidine = 3 S-adenosyl-L-homocysteine + hercynine
Other sequences found for EC No. 2.1.1.44
General information:
Sequence
0 MPSAESMTPS SALGQLKATG QHVLSKLQQQ TSNADIIDIR RVAVEINLKT EITSMFRPKD
60 GPRQLPTLLL YNERGLQLFE RITYLEEYYL TNDEIKILTK HATEMASFIP SGAMIIELGS
120 GNLRKVNLLL EALDNAGKAI DYYALDLSRE ELERTLAQVP SYKHVKCHGL LGTYDDGRDW
180 LKAPENINKQ KCILHLGSSI GNFNRSDAAT FLKGFTDVLG PNDKMLIGVD ACNDPARVYH
240 AYNDKVGITH EFILNGLRNA NEIIGETAFI EGDWRVIGEY VYDEEGGRHQ AFYAPTRDTM
300 VMGELIRSHD RIQIEQSLKY SKEESERLWS TAGLEQVSEW TYGNEYGLHL LAKSRMSFSL
360 IPSVYARSAL PTLDDWEALW ATWDVVTRQM LPQEELLEKP IKLRNACIFY LGHIPTFLDI
420 QLTKTTKQAP SEPAHFCKIF ERGIDPDVDN PELCHAHSEI PDEWPPVEEI LTYQETVRSR
480 LRGLYAHGIA NIPRNVGRAI WVGFEHELMH IETLLYMMLQ SDKTLIPTHI PRPDFDKLAR
540 KAESERVPNQ WFKIPAQEIT IGLDDPEDGS DINKHYGWDN EKPPRRVQVA AFQAQGRPIT
600 NEEYAQYLLE KNIDKLPASW ARLDNENISN GTTNSVSGHH SNRTSKQQLP SSFLEKTAVR
660 TVYGLVPLKH ALDWPVFASY DELAGCAAYM GGRIPTFEET RSIYAYADAL KKKKEAERQL
720 GRTVPAVNAH LTNNGVEITP PSSPSSETPA ESSSPSDSNT TLITTEDLFS DLDGANVGFH
780 NWHPMPITSK GNTLVGQGEL GGVWEWTSSV LRKWEGFEPM ELYPGYTADF FDEKHNIVLG
840 GSWATHPRIA GRKSFVNWYQ RNYPYAWVGA RVVRDL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
923348
Galagan J.E.,Calvo S.E.,Borkovich K.A.,Selker E.U.,Read N.D.,Jaffe D.B.,FitzHugh W.,Ma L.-J.,Smirnov S.,Purcell S.,Rehman B.,Elkins T.,Engels R.,Wang S.,Nielsen C.B.,Butler J.,Endrizzi M.,Qui D.,Ianakiev P.,Bell-Pedersen D.,Nelson M.A.,Werner-Washburne M.,Selitrennikoff C.P.,Kinsey J.A.,Braun E.L.,Zelter A.,Schulte U.,Kothe G.O.,Jedd G.,Mewes H.-W.,Staben C.,Marcotte E.,Greenberg D.,Roy A.,Foley K.,Naylor J.,Stange-Thomann N.,Barrett R.,Gnerre S.,Kamal M.,Kamvysselis M.,Mauceli E.W.,Bielke C.,Rudd S.,Frishman D.,Krystofova S.,Rasmussen C.,Metzenberg R.L.,Perkins D.D.,Kroken S.,Cogoni C.,Macino G.,Catcheside D.E.A.,Li W.,Pratt R.J.,Osmani S.A.,DeSouza C.P.C.,Glass N.L.,Orbach M.J.,Berglund J.A.,Voelker R.,Yarden O.,Plamann M.,Seiler S.,Dunlap J.C.,Radford A.,Aramayo R.,Natvig D.O.,Alex L.A.,Mannhaupt G.,Ebbole D.J.,Freitag M.,Paulsen I.,Sachs M.S.,Lander E.S.,Nusbaum C.,Birren B.W.
The genome sequence of the filamentous fungus Neurospora crassa.
Nature
422
859-868
2003
923349
Ishikawa Y.,Melville D.B.
The enzymatic alpha-N-methylation of histidine.
J. Biol. Chem.
245
5967-5973
1970
923350
Ishikawa Y.,Israel S.E.,Melville D.B.
Participation of an intermediate sulfoxide in the enzymatic thiolation of the imidazole ring of hercynine to form ergothioneine.
J. Biol. Chem.
249
4420-4427
1974
923351
Bello M.H.,Barrera-Perez V.,Morin D.,Epstein L.
The Neurospora crassa mutant NcDeltaEgt-1 identifies an ergothioneine biosynthetic gene and demonstrates that ergothioneine enhances conidial survival and protects against peroxide toxicity during conidial germination.
Fungal Genet. Biol.
49
160-172
2012
923352
Bello M.H.,Mogannam J.C.,Morin D.,Epstein L.
Endogenous ergothioneine is required for wild type levels of conidiogenesis and conidial survival but does not protect against 254 nm UV-induced mutagenesis or kill.
Fungal Genet. Biol.
73
120-127
2014
923353
Hu W.,Song H.,Sae Her A.,Bak D.W.,Naowarojna N.,Elliott S.J.,Qin L.,Chen X.,Liu P.
Bioinformatic and biochemical characterizations of C-S bond formation and cleavage enzymes in the fungus Neurospora crassa ergothioneine biosynthetic pathway.
Org. Lett.
16
5382-5385
2014
