Sequence of CBPC5_BOVIN
EC Number:3.4.17.24
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This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins. The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions. In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17, tubulinyl-Tyr carboxypeptidase). The latter is cleaved to delta2-tubulin and further to delta3-tubulin.
General information:
Sequence
0 MELRCGGLLF SSRFDSGNLA HVEKVESVSN DGEGVAGGAS ASTSSIASSP DYEFNVWTRP
60 DCAETEFENG NRSWFYFSVR GGTPGKLIKI NIMNMNKQSK LYSQGMAPFV RTLPTRPRWE
120 RIRDRPTFEM TETQFVLSFI HRFVEGRGAT TFFAFCYPFS YSDCQDLLSQ LDQRFLENSP
180 THSSPLDTIY YHRETLCYSL DGLRVDLLTI SSCHGLREDR EPRLEQLFPD ASTPRPFRFT
240 GKRIFFLSSR VHPGETPSSF VFNGFLDFIL RPDDPRAQTL RRLFVFKLIP MLNPDGVVRG
300 HYRTDSRGVN LNRQYLKPDA VLHPAIYGAK AVLLYHHVHS RLNSQSPSEH QHSSHLPPDA
360 PLSDPEKADS LQNRAHLGRS SSGDKPEAWT QTEVAEQKPN SVWITPQESA EVEQLAPDAI
420 PPRESGVAYY VDLHGHASKR GCFMYGNSFS DENTQVENML YPKLISLNSA HFDFQGCNFS
480 EKNMYARDRR DGQSKEGSGR VAIYKASGII HSYTLECNYN TGRSVNSIPA ACHDNGRASP
540 PPPPAFPSRY TVELFEQVGR AMAIAALDMA ECNPWPRIVL SEHSSLTNLR AWMLKHVRSS
600 RGLSTTVNMS ISKKRGSRTP PRSNNGLPVS CSENTLSRAR SFSTGTSAGG SSSSQQNSPQ
660 MKNSPSFPFH GSRPAGLPGL GSSTQKVSHR VLGPVREPRS QDRRRRQQPV THRPTSSSLA
720 PSPTPASSNL ASSHMGSCLL PNSLSISGSS CSFLSSGDKT EAVMVIGKGL LGAGPRIPCI
780 RTRLQARPRL AQGSPPTRRG MRGSPGPTSP IPQTKKSSEP ELGPRCTPRL PQAGPPRPCS
840 APAFSPISCS LSDSQSRICY SGGPLGQTEV CFVPKSPPFT VSPRV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
868184
Harhay G.P.,Sonstegard T.S.,Keele J.W.,Heaton M.P.,Clawson M.L.,Snelling W.M.,Wiedmann R.T.,Van Tassell C.P.,Smith T.P.L.
Characterization of 954 bovine full-CDS cDNA sequences.
BMC Genomics
6
166-166
2005
868185
The genome sequence of taurine cattle: a window to ruminant biology and evolution.
Science
324
522-528
2009
