Sequence of THRB_BOVIN
EC Number:3.4.21.5
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B
Other sequences found for EC No. 3.4.21.5
General information:
Sequence
0 MARVRGPRLP GCLALAALFS LVHSQHVFLA HQQASSLLQR ARRANKGFLE EVRKGNLERE
60 CLEEPCSREE AFEALESLSA TDAFWAKYTA CESARNPREK LNECLEGNCA EGVGMNYRGN
120 VSVTRSGIEC QLWRSRYPHK PEINSTTHPG ADLRENFCRN PDGSITGPWC YTTSPTLRRE
180 ECSVPVCGQD RVTVEVIPRS GGSTTSQSPL LETCVPDRGR EYRGRLAVTT SGSRCLAWSS
240 EQAKALSKDQ DFNPAVPLAE NFCRNPDGDE EGAWCYVADQ PGDFEYCDLN YCEEPVDGDL
300 GDRLGEDPDP DAAIEGRTSE DHFQPFFNEK TFGAGEADCG LRPLFEKKQV QDQTEKELFE
360 SYIEGRIVEG QDAEVGLSPW QVMLFRKSPQ ELLCGASLIS DRWVLTAAHC LLYPPWDKNF
420 TVDDLLVRIG KHSRTRYERK VEKISMLDKI YIHPRYNWKE NLDRDIALLK LKRPIELSDY
480 IHPVCLPDKQ TAAKLLHAGF KGRVTGWGNR RETWTTSVAE VQPSVLQVVN LPLVERPVCK
540 ASTRIRITDN MFCAGYKPGE GKRGDACEGD SGGPFVMKSP YNNRWYQMGI VSWGEGCDRD
600 GKYGFYTHVF RLKKWIQKVI DRLGS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
874697
Irwin D.M.,Robertson K.A.,Macgillivray R.T.A.
Structure and evolution of the bovine prothrombin gene.
J. Mol. Biol.
200
31-45
1988
874698
McGillivray R.T.A.,Davie E.W.
Characterization of bovine prothrombin mRNA and its translation product.
Biochemistry
23
1626-1634
1984
874701
Irwin D.M.,Ahern K.G.,Pearson G.D.,McGillivray R.T.A.
Characterization of the bovine prothrombin gene.
Biochemistry
24
6854-6861
1985
874702
Park C.H.,Tulinsky A.
Three-dimensional structure of the kringle sequence: structure of prothrombin fragment 1.
Biochemistry
25
3977-3982
1986
874703
Seshadri T.-P.,Tulinsky A.,Skrzypczak-Jankun E.,Park C.H.
Structure of bovine prothrombin fragment 1 refined at 2.25-A resolution.
J. Mol. Biol.
220
481-494
1991
874704
Soriano-Garcia M.,Padmanabhan K.,de Vos A.M.,Tulinsky A.
The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1.
Biochemistry
31
2554-2566
1992
874705
Martin P.D.,Robertson W.,Turk D.,Huber R.,Bode W.,Edwards B.F.P.
The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.
J. Biol. Chem.
267
7911-7920
1992
874706
Vitali J.,Martin P.D.,Malkowski M.G.,Robertson W.D.,Lazar J.B.,Winant R.C.,Johnson P.H.,Edwards B.F.P.
The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution.
J. Biol. Chem.
267
17670-17678
1992
874707
Brandstetter H.,Turk D.,Hoeffken H.W.,Grosse D.,Stuerzebecher J.,Martin P.D.,Edwards B.F.P.,Bode W.
Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
J. Mol. Biol.
226
1085-1099
1992
874708
van de Locht A.,Stubbs M.T.,Bode W.,Friedrich T.,Bollschweiler C.,Hoffken W.,Huber R.
The ornithodorin-thrombin crystal structure, a key to the TAP enigma?
EMBO J.
15
6011-6017
1996
874709
Fuentes-Prior P.,Noeske-Jungblut C.,Donner P.,Schleuning W.-D.,Huber R.,Bode W.
Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug.
Proc. Natl. Acad. Sci. U.S.A.
94
11845-11850
1997
874710
Huang M.,Rigby A.C.,Morelli X.,Grant M.A.,Huang G.,Furie B.,Seaton B.,Furie B.C.
Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins.
Nat. Struct. Biol.
10
751-756
2003
