Sequence of ALGG_PSEAE
EC Number:5.1.3.37
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
mannuronan 5-epimerase
Q51371
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
543
59802
Reaction
[mannuronan]-beta-D-mannuronate = [alginate]-alpha-L-guluronate
General information:
Sequence
0 MPDISLSIPR RRLPRLRPLA AAVLGAVLLH GQAWAAQPVE KPQPVPAQAG NEPGLTQGLK
60 ETGNYTVTTA PAEPLHLDPP KLPDLSGYTA AAVEAKIVRK PGGRASVQRM VQQQPLKEFT
120 GGSNRLAEWV KRQRQMPQAI FIEGGYVNLA QLAGKLPASA LEQVEPGVFV ARLPIVVSQG
180 ATLDIDKQVK ELRLSQERGA FLVNDGMLFV RDSKVTGWSE SKKEPAWFKT PNEFRPFLIS
240 WGGAEVYLSN STFTSFGYNA SKAYGISISQ YSPGMDKQMK RPRPKGWVID STIVDSWYGF
300 YCYEADDLVV KGNTYRDNIV YGIDPHDRSH RLIIADNTVH GTRKKHGIIV SREVNDSFIF
360 NNRSYENKLS GIVLDRNSEG NLVAYNEVYR NHSDGITLYE SGDNLLWGNQ VLANRRHGIR
420 VRNSVNIRLY ENLAAGNQLI GVYGHIKDLT NTDRNIALDP FDTKVSLIVV GGKLAGNGSG
480 PLSVDSPLSL ELYRVAMLAP TKSSGISLPG VLGEKQDQIL DLLVRQDKAV LIDPVESQAE
540 LQD
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
854177
Franklin M.J.,Chitnis C.E.,Gacesa P.,Sonesson A.,White D.C.,Ohman D.E.
Pseudomonas aeruginosa AlgG is a polymer level alginate C5-mannuronan epimerase.
J. Bacteriol.
176
1821-1830
1994
854178
Monday S.R.,Schiller N.L.
Alginate synthesis in Pseudomonas aeruginosa: the role of AlgL (alginate lyase) and AlgX.
J. Bacteriol.
178
625-632
1996
854179
Stover C.K.,Pham X.-Q.T.,Erwin A.L.,Mizoguchi S.D.,Warrener P.,Hickey M.J.,Brinkman F.S.L.,Hufnagle W.O.,Kowalik D.J.,Lagrou M.,Garber R.L.,Goltry L.,Tolentino E.,Westbrock-Wadman S.,Yuan Y.,Brody L.L.,Coulter S.N.,Folger K.R.,Kas A.,Larbig K.,Lim R.M.,Smith K.A.,Spencer D.H.,Wong G.K.-S.,Wu Z.,Paulsen I.T.,Reizer J.,Saier M.H. Jr.,Hancock R.E.W.,Lory S.,Olson M.V.
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Nature
406
959-964
2000
854180
Jain S.,Franklin M.J.,Ertesvaag H.,Valla S.,Ohman D.E.
The dual roles of AlgG in C-5-epimerization and secretion of alginate polymers in Pseudomonas aeruginosa.
Mol. Microbiol.
47
1123-1133
2003
854181
Douthit S.A.,Dlakic M.,Ohman D.E.,Franklin M.J.
Epimerase active domain of Pseudomonas aeruginosa AlgG, a protein that contains a right-handed beta-helix.
J. Bacteriol.
187
4573-4583
2005
854182
Jerga A.,Stanley M.D.,Tipton P.A.
Chemical mechanism and specificity of the C5-mannuronan epimerase reaction.
Biochemistry
45
9138-9144
2006
