Sequence of CAN3_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
calpain-3
P20807
Homo sapiens
821
94254
Reaction
broad endopeptidase activity
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MPTVISASVA PRTAAEPRSP GPVPHPAQSK ATEAGGGNPS GIYSAIISRN FPIIGVKEKT
 60 FEQLHKKCLE KKVLYVDPEF PPDETSLFYS QKFPIQFVWK RPPEICENPR FIIDGANRTD
120 ICQGELGDCW FLAAIACLTL NQHLLFRVIP HDQSFIENYA GIFHFQFWRY GEWVDVVIDD
180 CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK GGNTTEAMED FTGGVAEFFE
240 IRDAPSDMYK IMKKAIERGS LMGCSIDDGT NMTYGTSPSG LNMGELIARM VRNMDNSLLQ
300 DSDLDPRGSD ERPTRTIIPV QYETRMACGL VRGHAYSVTG LDEVPFKGEK VKLVRLRNPW
360 GQVEWNGSWS DRWKDWSFVD KDEKARLQHQ VTEDGEFWMS YEDFIYHFTK LEICNLTADA
420 LQSDKLQTWT VSVNEGRWVR GCSAGGCRNF PDTFWTNPQY RLKLLEEDDD PDDSEVICSF
480 LVALMQKNRR KDRKLGASLF TIGFAIYEVP KEMHGNKQHL QKDFFLYNAS KARSKTYINM
540 REVSQRFRLP PSEYVIVPST YEPHQEGEFI LRVFSEKRNL SEEVENTISV DRPVKKKKTK
600 PIIFVSDRAN SNKELGVDQE SEEGKGKTSP DKQKQSPQPQ PGSSDQESEE QQQFRNIFKQ
660 IAGDDMEICA DELKKVLNTV VNKHKDLKTH GFTLESCRSM IALMDTDGSG KLNLQEFHHL
720 WNKIKAWQKI FKHYDTDQSG TINSYEMRNA VNDAGFHLNN QLYDIITMRY ADKHMNIDFD
780 SFICCFVRLE GMFRAFHAFD KDGDGIIKLN VLEWLQLTMY A
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
868380
Richard I.,Broux O.,Allamand V.,Fougerousse F.,Chiannilkulchai N.,Bourg N.,Brenguier L.,Devaud C.,Pasturaud P.,Roudaut C.,Hillaire D.,Passos-Bueno M.-R.,Zatz M.,Tischfield J.A.,Fardeau M.,Jackson C.E.,Cohen D.,Beckmann J.S.
Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A.
Cell
81
27-40
1995
868385
Zody M.C.,Garber M.,Sharpe T.,Young S.K.,Rowen L.,O'Neill K.,Whittaker C.A.,Kamal M.,Chang J.L.,Cuomo C.A.,Dewar K.,FitzGerald M.G.,Kodira C.D.,Madan A.,Qin S.,Yang X.,Abbasi N.,Abouelleil A.,Arachchi H.M.,Baradarani L.,Birditt B.,Bloom S.,Bloom T.,Borowsky M.L.,Burke J.,Butler J.,Cook A.,DeArellano K.,DeCaprio D.,Dorris L. III,Dors M.,Eichler E.E.,Engels R.,Fahey J.,Fleetwood P.,Friedman C.,Gearin G.,Hall J.L.,Hensley G.,Johnson E.,Jones C.,Kamat A.,Kaur A.,Locke D.P.,Madan A.,Munson G.,Jaffe D.B.,Lui A.,Macdonald P.,Mauceli E.,Naylor J.W.,Nesbitt R.,Nicol R.,O'Leary S.B.,Ratcliffe A.,Rounsley S.,She X.,Sneddon K.M.B.,Stewart S.,Sougnez C.,Stone S.M.,Topham K.,Vincent D.,Wang S.,Zimmer A.R.,Birren B.W.,Hood L.,Lander E.S.,Nusbaum C.
Analysis of the DNA sequence and duplication history of human chromosome 15.
Nature
440
671-675
2006
868386
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
868387
Sorimachi H.,Imajoh-Ohmi S.,Emori Y.,Kawasaki H.,Ohno S.,Minami Y.,Suzuki K.
Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle.
J. Biol. Chem.
264
20106-20111
1989
868388
Miller M.K.,Bang M.-L.,Witt C.C.,Labeit D.,Trombitas C.,Watanabe K.,Granzier H.,McElhinny A.S.,Gregorio C.C.,Labeit S.
The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.
J. Mol. Biol.
333
951-964
2003
868389
Richard I.,Roudaut C.,Saenz A.,Pogue R.,Grimbergen J.E.M.A.,Anderson L.V.B.,Beley C.,Cobo A.-M.,de Diego C.,Eymard B.,Gallano P.,Ginjaar H.B.,Lasa A.,Pollitt C.,Topaloglu H.,Urtizberea J.A.,de Visser M.,van der Kooi A.,Bushby K.,Bakker E.,Lopez de Munain A.,Fardeau M.,Beckmann J.S.
Calpainopathy -- a survey of mutations and polymorphisms.
Am. J. Hum. Genet.
64
1524-1540
1999
868390
Sarparanta J.,Blandin G.,Charton K.,Vihola A.,Marchand S.,Milic A.,Hackman P.,Ehler E.,Richard I.,Udd B.
Interactions with M-band titin and calpain 3 link myospryn (CMYA5) to tibial and limb-girdle muscular dystrophies.
J. Biol. Chem.
285
30304-30315
2010
868391
Partha S.K.,Ravulapalli R.,Allingham J.S.,Campbell R.L.,Davies P.L.
Crystal structure of calpain-3 penta-EF-hand (PEF) domain - a homodimerized PEF family member with calcium bound at the fifth EF-hand.
FEBS J.
281
3138-3149
2014
868392
Fardeau M.,Hillaire D.,Mignard C.,Feingold N.,Feingold J.,Mignard D.,de Ubeda B.,Collin H.,Tome F.M.S.,Richard I.,Beckmann J.S.
Juvenile limb-girdle muscular dystrophy. Clinical, histopathological and genetic data from a small community living in the Reunion island.
Brain
119
295-308
1996
868393
Richard I.,Brenguier L.,Dincer P.,Roudaut C.,Bady B.,Burgunder J.-M.,Chemaly R.,Garcia C.A.,Halaby G.,Jackson C.E.,Kurnit D.M.,Lefranc G.,Legum C.,Loiselet J.,Merlini L.,Nivelon-Chevallier A.,Ollagnon-Roman E.,Restagno G.,Topaloglu H.,Beckmann J.S.
Multiple independent molecular etiology for limb-girdle muscular dystrophy type 2A patients from various geographical origins.
Am. J. Hum. Genet.
60
1128-1138
1997
868394
Dincer P.,Leturcq F.,Richard I.,Piccolo F.,Yalnizoglu D.,de Toma C.,Akcoeren Z.,Broux O.,Deburgrave N.,Brenguier L.,Roudaut C.,Urtizberea J.A.,Jung D.,Tan E.,Jeanpierre M.,Campbell K.P.,Kaplan J.-C.,Beckmann J.S.,Topaloglu H.
A biochemical, genetic, and clinical survey of autosomal recessive limb girdle muscular dystrophies in Turkey.
Ann. Neurol.
42
222-229
1997
868395
Urtasun M.,Saenz A.,Roudaut C.,Poza J.J.,Urtizberea J.A.,Cobo A.-M.,Richard I.,Garcia Bragado F.,Leturcq F.,Kaplan J.-C.,Marti Masso J.F.,Beckmann J.S.,Lopez de Munain A.
Limb-girdle muscular dystrophy in Guipuzcoa (Basque Country, Spain).
Brain
121
1735-1747
1998
868396
Haeffner K.,Speer A.,Huebner C.,Voit T.,Oexle K.
A small in-frame deletion within the protease domain of muscle-specific calpain, p94 causes early-onset limb-girdle muscular dystrophy 2A.
Hum. Mutat. Suppl.
1
0-0
1998
868397
Penisson-Besnier I.,Richard I.,Dubas F.,Beckmann J.S.,Fardeau M.
Pseudometabolic expression and phenotypic variability of calpain deficiency in two siblings.
Muscle Nerve
21
1078-1080
1998
868398
Kawai H.,Akaike M.,Kunishige M.,Inui T.,Adachi K.,Kimura C.,Kawajiri M.,Nishida Y.,Endo I.,Kashiwagi S.,Nishino H.,Fujiwara T.,Okuno S.,Roudaut C.,Richard I.,Beckmann J.S.,Miyoshi K.,Matsumoto T.
Clinical, pathological, and genetic features of limb-girdle muscular dystrophy type 2A with new calpain 3 gene mutations in seven patients from three Japanese families.
Muscle Nerve
21
1493-1501
1998
868399
Fattahi Z.,Kalhor Z.,Fadaee M.,Vazehan R.,Parsimehr E.,Abolhassani A.,Beheshtian M.,Zamani G.,Nafissi S.,Nilipour Y.,Akbari M.R.,Kahrizi K.,Kariminejad A.,Najmabadi H.
Improved diagnostic yield of neuromuscular disorders applying clinical exome sequencing in patients arising from a consanguineous population.
Clin. Genet.
91
386-402
2017
868400
Fadaee M.,Kariminejad A.,Fattahi Z.,Nafissi S.,Godarzi H.R.,Beheshtian M.,Vazehan R.,Akbari M.R.,Kahrizi K.,Najmabadi H.
Report of limb girdle muscular dystrophy type 2a in 6 Iranian patients, one with a novel deletion in CAPN3 gene.
Neuromuscul. Disord.
26
277-282
2016
868401
Vissing J.,Barresi R.,Witting N.,Van Ghelue M.,Gammelgaard L.,Bindoff L.A.,Straub V.,Lochmueller H.,Hudson J.,Wahl C.M.,Arnardottir S.,Dahlbom K.,Jonsrud C.,Duno M.
A heterozygous 21-bp deletion in CAPN3 causes dominantly inherited limb girdle muscular dystrophy.
Brain
139
2154-2163
2016
868402
Martinez-Thompson J.M.,Niu Z.,Tracy J.A.,Moore S.A.,Swenson A.,Wieben E.D.,Milone M.
Autosomal dominant calpainopathy due to heterozygous CAPN3 C.643_663del21.
Muscle Nerve
57
679-683
2018