Sequence of PP2BA_MOUSE
EC Number:3.1.3.16
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate
Other sequences found for EC No. 3.1.3.16
General information:
Sequence
0 MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV
60 ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV
120 DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD
180 AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG
240 NEKTQEHFTH NTVRGCSYFY SYPAVCDFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP
300 SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK
360 VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV
420 LTLKGLTPTG MLPSGVLSGG KQTLQSATVE AIEADEAIKG FSPQHKITSF EEAKGLDRIN
480 ERMPPRRDAM PSDANLNSIN KALASETNGT DSNGSNSSNI Q
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
77487
Kincaid R.L.,Giri P.R.,Higuchi S.,Tamura J.,Dixon S.C.,Marietta C.A.,Amorese D.A.,Martin B.M.
Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.
J. Biol. Chem.
265
11312-11319
1990
77488
Carninci P.,Kasukawa T.,Katayama S.,Gough J.,Frith M.C.,Maeda N.,Oyama R.,Ravasi T.,Lenhard B.,Wells C.,Kodzius R.,Shimokawa K.,Bajic V.B.,Brenner S.E.,Batalov S.,Forrest A.R.,Zavolan M.,Davis M.J.,Wilming L.G.,Aidinis V.,Allen J.E.,Ambesi-Impiombato A.,Apweiler R.,Aturaliya R.N.,Bailey T.L.,Bansal M.,Baxter L.,Beisel K.W.,Bersano T.,Bono H.,Chalk A.M.,Chiu K.P.,Choudhary V.,Christoffels A.,Clutterbuck D.R.,Crowe M.L.,Dalla E.,Dalrymple B.P.,de Bono B.,Della Gatta G.,di Bernardo D.,Down T.,Engstrom P.,Fagiolini M.,Faulkner G.,Fletcher C.F.,Fukushima T.,Furuno M.,Futaki S.,Gariboldi M.,Georgii-Hemming P.,Gingeras T.R.,Gojobori T.,Green R.E.,Gustincich S.,Harbers M.,Hayashi Y.,Hensch T.K.,Hirokawa N.,Hill D.,Huminiecki L.,Iacono M.,Ikeo K.,Iwama A.,Ishikawa T.,Jakt M.,Kanapin A.,Katoh M.,Kawasawa Y.,Kelso J.,Kitamura H.,Kitano H.,Kollias G.,Krishnan S.P.,Kruger A.,Kummerfeld S.K.,Kurochkin I.V.,Lareau L.F.,Lazarevic D.,Lipovich L.,Liu J.,Liuni S.,McWilliam S.,Madan Babu M.,Madera M.,Marchionni L.,Matsuda H.,Matsuzawa S.,Miki H.,Mignone F.,Miyake S.,Morris K.,Mottagui-Tabar S.,Mulder N.,Nakano N.,Nakauchi H.,Ng P.,Nilsson R.,Nishiguchi S.,Nishikawa S.,Nori F.,Ohara O.,Okazaki Y.,Orlando V.,Pang K.C.,Pavan W.J.,Pavesi G.,Pesole G.,Petrovsky N.,Piazza S.,Reed J.,Reid J.F.,Ring B.Z.,Ringwald M.,Rost B.,Ruan Y.,Salzberg S.L.,Sandelin A.,Schneider C.,Schoenbach C.,Sekiguchi K.,Semple C.A.,Seno S.,Sessa L.,Sheng Y.,Shibata Y.,Shimada H.,Shimada K.,Silva D.,Sinclair B.,Sperling S.,Stupka E.,Sugiura K.,Sultana R.,Takenaka Y.,Taki K.,Tammoja K.,Tan S.L.,Tang S.,Taylor M.S.,Tegner J.,Teichmann S.A.,Ueda H.R.,van Nimwegen E.,Verardo R.,Wei C.L.,Yagi K.,Yamanishi H.,Zabarovsky E.,Zhu S.,Zimmer A.,Hide W.,Bult C.,Grimmond S.M.,Teasdale R.D.,Liu E.T.,Brusic V.,Quackenbush J.,Wahlestedt C.,Mattick J.S.,Hume D.A.,Kai C.,Sasaki D.,Tomaru Y.,Fukuda S.,Kanamori-Katayama M.,Suzuki M.,Aoki J.,Arakawa T.,Iida J.,Imamura K.,Itoh M.,Kato T.,Kawaji H.,Kawagashira N.,Kawashima T.,Kojima M.,Kondo S.,Konno H.,Nakano K.,Ninomiya N.,Nishio T.,Okada M.,Plessy C.,Shibata K.,Shiraki T.,Suzuki S.,Tagami M.,Waki K.,Watahiki A.,Okamura-Oho Y.,Suzuki H.,Kawai J.,Hayashizaki Y.
The transcriptional landscape of the mammalian genome.
Science
309
1559-1563
2005
77489
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
77491
Becker W.,Kentrup H.,Klumpp S.,Schultz J.E.,Joost H.G.
Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain.
J. Biol. Chem.
269
22586-22592
1994
77492
Kincaid R.L.,Nightingale M.S.,Martin B.M.
Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin.
Proc. Natl. Acad. Sci. U.S.A.
85
8983-8987
1988
77493
Fruman D.A.,Pai S.-Y.,Burakoff S.J.,Bierer B.E.
Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells.
Mol. Cell. Biol.
15
3857-3863
1995
77494
Zhang B.W.,Zimmer G.,Chen J.,Ladd D.,Li E.,Alt F.W.,Wiederrecht G.,Cryan J.,O'Neill E.A.,Seidman C.E.,Abbas A.K.,Seidman J.G.
T cell responses in calcineurin A alpha-deficient mice.
J. Exp. Med.
183
413-420
1996
77495
Zhuo M.,Zhang W.,Son H.,Mansuy I.,Sobel R.A.,Seidman J.,Kandel E.R.
A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus.
Proc. Natl. Acad. Sci. U.S.A.
96
4650-4655
1999
77496
Frey N.,Richardson J.A.,Olson E.N.
Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.
Proc. Natl. Acad. Sci. U.S.A.
97
14632-14637
2000
77497
Genesca L.,Aubareda A.,Fuentes J.J.,Estivill X.,De La Luna S.,Perez-Riba M.
Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.
Biochem. J.
374
567-575
2003
77498
Parsons S.A.,Wilkins B.J.,Bueno O.F.,Molkentin J.D.
Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.
Mol. Cell. Biol.
23
4331-4343
2003
77499
Gooch J.L.,Toro J.J.,Guler R.L.,Barnes J.L.
Calcineurin A-alpha but not A-beta is required for normal kidney development and function.
Am. J. Pathol.
165
1755-1765
2004
77500
Sun L.,Blair H.C.,Peng Y.,Zaidi N.,Adebanjo O.A.,Wu X.B.,Wu X.Y.,Iqbal J.,Epstein S.,Abe E.,Moonga B.S.,Zaidi M.
Calcineurin regulates bone formation by the osteoblast.
Proc. Natl. Acad. Sci. U.S.A.
102
17130-17135
2005
77501
Sacksteder C.A.,Qian W.-J.,Knyushko T.V.,Wang H.,Chin M.H.,Lacan G.,Melega W.P.,Camp D.G. II,Smith R.D.,Smith D.J.,Squier T.C.,Bigelow D.J.
Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease.
Biochemistry
45
8009-8022
2006
77502
Gooch J.L.,Guler R.L.,Barnes J.L.,Toro J.J.
Loss of calcineurin Aalpha results in altered trafficking of AQP2 and in nephrogenic diabetes insipidus.
J. Cell Sci.
119
2468-2476
2006
77503
Sun L.,Peng Y.,Zaidi N.,Zhu L.L.,Iqbal J.,Yamoah K.,Wang X.,Liu P.,Abe E.,Moonga B.S.,Epstein S.,Zaidi M.
Evidence that calcineurin is required for the genesis of bone-resorbing osteoclasts.
Am. J. Physiol.
292
0-0
2007
77504
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
77505
Pena J.A.,Losi-Sasaki J.L.,Gooch J.L.
Loss of calcineurin Aalpha alters keratinocyte survival and differentiation.
J. Invest. Dermatol.
130
135-140
2010
77506
Heineke J.,Auger-Messier M.,Correll R.N.,Xu J.,Benard M.J.,Yuan W.,Drexler H.,Parise L.V.,Molkentin J.D.
CIB1 is a regulator of pathological cardiac hypertrophy.
Nat. Med.
16
872-879
2010
77507
Reddy R.N.,Pena J.A.,Roberts B.R.,Williams S.R.,Price S.R.,Gooch J.L.
Rescue of calcineurin Aalpha(-/-) mice reveals a novel role for the alpha isoform in the salivary gland.
Am. J. Pathol.
178
1605-1613
2011
77508
Kielbasa O.M.,Reynolds J.G.,Wu C.L.,Snyder C.M.,Cho M.Y.,Weiler H.,Kandarian S.,Naya F.J.
Myospryn is a calcineurin-interacting protein that negatively modulates slow-fiber-type transformation and skeletal muscle regeneration.
FASEB J.
25
2276-2286
2011
77509
Shinzawa M.,Konno H.,Qin J.,Akiyama N.,Miyauchi M.,Ohashi H.,Miyamoto-Sato E.,Yanagawa H.,Akiyama T.,Inoue J.
Catalytic subunits of the phosphatase calcineurin interact with NF-kappaB-inducing kinase (NIK) and attenuate NIK-dependent gene expression.
Sci. Rep.
5
10758-10758
2015
77510
Sonntag T.,Ostojic J.,Vaughan J.M.,Moresco J.J.,Yoon Y.S.,Yates J.R. III,Montminy M.
Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.
IScience
11
134-145
2018
77511
Chaya T.,Tsutsumi R.,Varner L.R.,Maeda Y.,Yoshida S.,Furukawa T.
Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.
EMBO J.
2019
0-0
2019
77512
Li S.J.,Wang J.,Ma L.,Lu C.,Wang J.,Wu J.W.,Wang Z.X.
Cooperative autoinhibition and multi-level activation mechanisms of calcineurin.
Cell Res.
26
336-349
2016
