Sequence of NEP_RABIT
EC Number:3.4.24.11
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'
Other sequences found for EC No. 3.4.24.11
General information:
Sequence
0 MGRSESQMDI TDINTPKPKK KQRWTPLEIS LSVLVLLLTV IAVTMIALYA TYDDGICKSS
60 DCIKSAARLI QNMDATAEPC TDFFKYACGG WLKRNVIPET SSRYSNFDIL RDELEVILKD
120 VLQEPKTEDI VAVQKAKTLY RSCVNETAID SRGGQPLLKL LPDVYGWPVA TQNWEQTYGT
180 SWSAEKSIAQ LNSNYGKKVL INFFVGTDDK NSMNHIIHID QPRLGLPSRD YYECTGIYKE
240 ACTAYVDFMI AVAKLIRQEE GLPIDENQIS VEMNKVMELE KEIANATTKS EDRNDPMLLY
300 NKMTLAQIQN NFSLEINGKP FSWSNFTNEI MSTVNINIPN EEDVVVYAPE YLIKLKPILT
360 KYFPRDFQNL FSWRFIMDLV SSLSRTYKDS RNAFRKALYG TTSESATWRR CANYVNGNME
420 NAVGRLYVEA AFAGESKHVV EDLIAQIREV FIQTLDDLTW MDAETKKKAE EKALAIKERI
480 GYPDDIVSND NKLNNEYLEL NYKEDEYFEN IIQNLKFSQS KQLKKLREKV DKDEWITGAA
540 IVNAFYSSGR NQIVFPAGIL QPPFFSAQQS NSLNYGGIGM VIGHEITHGF DDNGRNFNKD
600 GDLVDWWTQQ SANNFKEQSQ CMVYQYGNFS WDLAGGQHLN GINTLGENIA DNGGIGQAYR
660 AYQNYVKKNG EEKLLPGIDL NHKQLFFLNF AQVWCGTYRP EYAVNSIKTD VHSPGNFRII
720 GSLQNSVEFS EAFQCPKNSY MNPEKKCRVW
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
831202
Devault A.,Lazure C.,Nault C.,le Moual H.,Seidah N.G.,Chretien M.,Kahn P.,Powell J.,Mallet J.,Beaumont A.,Roques B.P.,Crine P.,Boileau G.
Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA.
EMBO J.
6
1317-1322
1987
831204
Kahn P.H.,Powell J.F.,Beaumont A.,Roques B.P.,Mallet J.J.
An antibody purified with a lambda GT11 fusion protein precipitates enkephalinase activity.
Biochem. Biophys. Res. Commun.
145
488-493
1987
831205
Devault A.,Sales V.,Nault C.,Beaumont A.,Roques B.,Crine P.,Boileau G.
Exploration of the catalytic site of endopeptidase 24.11 by site-directed mutagenesis. Histidine residues 583 and 587 are essential for catalysis.
FEBS Lett.
231
54-58
1988
831206
Fournie-Zaluski M.C.,Gonzalez W.,Turcaud S.,Pham I.,Roques B.P.,Michel J.B.
Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase by the orally active inhibitor mixanpril: a potential therapeutic approach in hypertension.
Proc. Natl. Acad. Sci. U.S.A.
91
4072-4076
1994
