Sequence of MOKA_MONPI
EC Number:2.3.1.161
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
9 malonyl-CoA + 11 NADPH + 10 H+ + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] = dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O
Other sequences found for EC No. 2.3.1.161
General information:
Sequence
0 MYVGRIGATT YISRPADSRA TPKVIKTQGS ITTSNLTSLT TMAQSTYPNE PIVVVGSGCR
60 FPGGANTPSK LWELLREPRD VRSKIPKERF DVDAFYHPDG KHHGRTNAPY AYMLQEDLRA
120 FDGPFFNIQA GEAESMDPQQ RLLLETVYEA VSDAGMRIQD LQGSSTAVYV GMMTHDYETV
180 STRDLESIPT YSATGVAVSV ASNRISYFFD WHGPSMTIDT ACSSSLVAVH LAVQQLRSGQ
240 SSMAIAAGAN MILGPMTFVL ESKLNMLSPS GRSRMWDAGA DGYARGEAVC SVVLKTLSQA
300 LRDGDSIECV IRETGVNQDG RTTGITMPNH SAQEALIRAT YSKAGLDITN PEDRCQFFEA
360 HGTGTPAGDP QEAEAIATAF FGHKKEASDA ENAETPLFVG SVKTVVGHTE GTAGLAGLMK
420 ASFAVQHGVI PPNLLFENIS PRVAPFYSNL KIATETTPWP TIKPGQPRRV SVNSFGFGGT
480 NAHAIIEEYI KSDQKVPASR QPVEYSDSPS TLNLPLVLSA KSQRSMKTTL ESMVQFLQSN
540 PEVNLRDLSW TLLRKRSILP FRRAIVGHSH EAIRAALEAA IEDGIVVSDF SADVKGKPSV
600 LGVFTGQGAQ WPGMLKELIV GSSYVRSIAE ELDHSLQTLP EKYRPSWTIL EQLMLEDEAS
660 NVRHASFSQP LCCAVQIVLV RLLKAAGIQF AAVVGHSSGE IACAFATGLI SASLAIRIAH
720 LRGVVSAEHA ASASGGRGSM LAAGMSYEEA KELCELDAFE SRICVAASNS PDSVTFSGDA
780 DAIEHLQGVL EDEATFARLL RVDTAYHSHH MLPCAAPYMQ ALEECGCAVA DGDGQVEEGS
840 WYSSVKDSNE PMGLADVTAE YWKDNLVSPV LFSQAVQRAA IMHRPLDVGI EVGCHPALKG
900 PCLATIKDAL SDVDLAYTGC LERGKNDMNA FSQALAYLWE QFGIPSLDAD RFISTIAPER
960 SCVSLSKQLP TYSWDHSRSY WTESRATRQH LRGPKPHLLL GKLSEYSTPL TFQWLNFVRP
1020 RDIEWLDGHA LQGQVVFPAA GYIVMAMEAA MEIANSHQVQ VQLLEILDMS IDKAVVFDDE
1080 DSLVELNLTA EVTSGIGKGD RMILSFIIDS CLSREGDLST SAKGQLVVTL DEGHLQVTPD
1140 NEKQLLPPPE EEHPHMNRVN INSFYHELDL MGYDYSKDFR RLHSMRRADA RASGILEFIP
1200 LNDEVHGRPL LLHPAPLDIA FQTVIGAYSS PGDRRLRCLY VPTHIDRIAL VPSLCLATAA
1260 SGCDKIAFNT INTYDKGDFL SGDIVAFDAE QTSLFHVENI VFKPFSPPTA STDHPIFAKW
1320 SWGPLTPETL LDNPNHWATA QDKEAIPIIE RIVYFYIKLF LQQLTREDRE QAAFHLQRQI
1380 VWCEQVVADA HEGRHQWYDA AWENDTEAQI EQLCARSSYH PHVRLVQRVG QNLLATIRSN
1440 GNPFDLMDHD GLLTEFYTNT LSFGPALHYA QDLVGQIAHR YQSMDILEIG AGTGGATKYV
1500 LATPQLGFNS YTYTDISTGF FEKAREQFAA FEDRMEFEPL DIRRSPAEQG FTEHVYDLII
1560 ASNVLHATPD LEKTMAHARS LLKPGGQMVI LEITHRNHTR LGFIFGLFAD WWAGIDDGRT
1620 MEPFVSFDRW DEILKHVGFS GIDSRTKDRD ADLFPTSVFS THAVNSTIDY LHKPLDAPVK
1680 DSYPPLVVVG GQTPKTQRIL DEIKAVMPNR QIQLHQRLVD LLDAEDMQAK FTFVVLTELD
1740 EELFAGLTED SFEAVKLLLM YAGNMLWLTE NAWVKRPHQA STIGMLRSIR REHPDIGVHI
1800 MDVDSAENLD AHFLVEQVLR LEEDIDELAA TTTWTQEPEV FWCNGRAWIP RLKHDKSRNN
1860 RMNSSRRQIF ETLNPSKIPV ALKKAAASSS YYLESAETWP VPGAVTAGDR KTVHVRLSHP
1920 HALRVGHLGF FYLVQGHVLK GDQALPVVAL AERNASIVHV RSDYVHVLED TAVSANNGSF
1980 ILAAAAAVLA ETVIHSAKSL GADASVLVLN APGFCAQTLL RAARDSGLRV HLATTSSSTD
2040 PSPGADRCVR LHPRDTDRRL KQLLPRGTQA FFDLSTDPSS EGLTQRLPNV LIPSCVRHST
2100 EYLLRDTASA GGKATLPAAY WERVASLANH SLSTHFKEND NASNGCQVLS CTDIVARNNK
2160 SRLNASTVIS WPDDAALPAR IRPIDTETLF AAEKTYLLVG LTGDLGRSLG RWMVLHGARR
2220 IVLTSRNPQV SPNWVAHVEE LGGQVTVLSM DVTSEDSVDS GLAKLQDLKL PPIGGIAFGP
2280 LVLQDVMLKN MDLQMMEMVL KPKVEGARIL HEKFSDPASS NPLDFFVMFS SIVAVMGNPG
2340 QANYSAANCY LQALAQRRCA SGLAASTIDI GAVYGVGFVT RAELEEDFNA IRFMFDSVEE
2400 HELHSLFAEA VVSGRRAMHQ QQQFKTVLDM ADIELTTGIP PLDPTLKDRI TFFDDARVGN
2460 FKIPERRGKA GDNAAGSKGS VKEQLLQATS LDQVRQIVID GLSEKLRVTL QIPDGESVHP
2520 TIPLIDQGVD SLGAVTVGTW FSKQLYLDLP LLRVLGGASV ADLADDAAAR LPPSSIPLVA
2580 ASEGGAETSD NDTSGPEGTD LSASTTITEP SSADEEDEKQ EDDNDNSVLA LHPLSLGQEY
2640 AWRLQKAADD STIFNNTIGM FMTGSIDAKR LSKALRAVLR RHEIFRTGFA AVGNNADATS
2700 LAQIVFGRTK NKVQVIQVAD RAGAEEGYRQ LVQTQYDITA GDTLRLVDFF WGKDEHLFVV
2760 AYHRFVGDGS TTENIFVEAS QLYGGVTLDK HVPQFADLAT RQREALESGQ MDADLAYWES
2820 MHHQPTGVVS PVLPRMLLGE DGLNSPNHAR QPNSWKQHEA IARLDPMVAF RIRERSRKHK
2880 ATPMQFYLAA YHVLLARLTG SSDFSIGLAD TNRTNVDELA GMGFFANLLP LRFRNFVPHI
2940 TFGEHLVATK DKVREAMQHA RVPYGVLLER LGFEVPGATA ETAEPAPLFQ AVFDYKQGQA
3000 ESGSIGSAKM TEVIATRERT PYDVVLEMSD DPTKDPLLTV KLQSSVYEVH HPRAFLESYI
3060 SILSMFSMNP ALKLA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
826008
Chen Y.P.,Tseng C.P.,Liaw L.L.,Wang C.L.,Chen I.C.,Wu W.J.,Wu M.D.,Yuan G.F.
Cloning and characterization of monacolin K biosynthetic gene cluster from Monascus pilosus.
J. Agric. Food Chem.
56
5639-5646
2008
826009
Sakai K.,Kinoshita H.,Nihira T.
Identification of mokB involved in monacolin K biosynthesis in Monascus pilosus.
Biotechnol. Lett.
31
1911-1916
2009
826010
Chen Y.-P.,Yuan G.-F.,Hsieh S.-Y.,Lin Y.-S.,Wang W.-Y.,Liaw L.-L.,Tseng C.-P.
Identification of the mokH gene encoding transcription factor for the upregulation of monacolin K biosynthesis in Monascus pilosus.
J. Agric. Food Chem.
58
287-293
2010
826011
Hong S.Y.,Oh J.H.,Lee I.
Simultaneous enrichment of deglycosylated ginsenosides and monacolin K in red ginseng by fermentation with Monascus pilosus.
Biosci. Biotechnol. Biochem.
75
1490-1495
2011
