Any feedback?
Please rate this page
(sequences.php)
(0/150)

BRENDA support

Sequence of PHLP1_HUMAN

EC Number:3.1.3.16

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
3.1.3.16
protein-serine/threonine phosphatase
O60346
Homo sapiens
1717
184672
Swiss-Prot
Reaction
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate
Other sequences found for EC No. 3.1.3.16

General information:

Sequence
show sequence in fasta format
   0 MEPAAAATVQ RLPELGREDR ASAPAAAAAA AAAAAAAAAA LAAAAGGGRS PEPALTPAAP
  60 SGGNGSGSGA REEAPGEAPP GPLPGRAGGA GRRRRRGAPQ PIAGGAAPVP GAGGGANSLL
 120 LRRGRLKRNL SAAAAAASSS SSSSAAAASH SPGAAGLPAS CSASASLCTR SLDRKTLLLK
 180 HRQTLQLQPS DRDWVRHQLQ RGCVHVFDRH MASTYLRPVL CTLDTTAGEV AARLLQLGHK
 240 GGGVVKVLGQ GPGAAAAREP AEPPPEAGPR LAPPEPRDSE VPPARSAPGA FGGPPRAPPA
 300 DLPLPVGGPG GWSRRASPAP SDSSPGEPFV GGPVSSPRAP RPVVSDTESF SLSPSAESVS
 360 DRLDPYSSGG GSSSSSEELE ADAASAPTGV PGQPRRPGHP AQPLPLPQTA SSPQPQQKAP
 420 RAIDSPGGAV REGSCEEKAA AAVAPGGLQS TPGRSGVTAE KAPPPPPPPT LYVQLHGETT
 480 RRLEAEEKPL QIQNDYLFQL GFGELWRVQE EGMDSEIGCL IRFYAGKPHS TGSSERIQLS
 540 GMYNVRKGKM QLPVNRWTRR QVILCGTCLI VSSVKDSLTG KMHVLPLIGG KVEEVKKHQH
 600 CLAFSSSGPQ SQTYYICFDT FTEYLRWLRQ VSKVASQRIS SVDLSCCSLE HLPANLFYSQ
 660 DLTHLNLKQN FLRQNPSLPA ARGLNELQRF TKLKSLNLSN NHLGDFPLAV CSIPTLAELN
 720 VSCNALRSVP AAVGVMHNLQ TFLLDGNFLQ SLPAELENMK QLSYLGLSFN EFTDIPEVLE
 780 KLTAVDKLCM SGNCVETLRL QALRKMPHIK HVDLRLNVIR KLIADEVDFL QHVTQLDLRD
 840 NKLGDLDAMI FNNIEVLHCE RNQLVTLDIC GYFLKALYAS SNELVQLDVY PVPNYLSYMD
 900 VSRNRLENVP EWVCESRKLE VLDIGHNQIC ELPARLFCNS SLRKLLAGHN QLARLPERLE
 960 RTSVEVLDVQ HNQLLELPPN LLMKADSLRF LNASANKLES LPPATLSEET NSILQELYLT
1020 NNSLTDKCVP LLTGHPHLKI LHMAYNRLQS FPASKMAKLE ELEEIDLSGN KLKAIPTTIM
1080 NCRRMHTVIA HSNCIEVFPE VMQLPEIKCV DLSCNELSEV TLPENLPPKL QELDLTGNPR
1140 LVLDHKTLEL LNNIRCFKID QPSTGDASGA PAVWSHGYTE ASGVKNKLCV AALSVNNFCD
1200 NREALYGVFD GDRNVEVPYL LQCTMSDILA EELQKTKNEE EYMVNTFIVM QRKLGTAGQK
1260 LGGAAVLCHI KHDPVDPGGS FTLTSANVGK CQTVLCRNGK PLPLSRSYIM SCEEELKRIK
1320 QHKAIITEDG KVNGVTESTR ILGYTFLHPS VVPRPHVQSV LLTPQDEFFI LGSKGLWDSL
1380 SVEEAVEAVR NVPDALAAAK KLCTLAQSYG CHDSISAVVV QLSVTEDSFC CCELSAGGAV
1440 PPPSPGIFPP SVNMVIKDRP SDGLGVPSSS SGMASEISSE LSTSEMSSEV GSTASDEPPP
1500 GALSENSPAY PSEQRCMLHP ICLSNSFQRQ LSSATFSSAF SDNGLDSDDE EPIEGVFTNG
1560 SRVEVEVDIH CSRAKEKEKQ QHLLQVPAEA SDEGIVISAN EDEPGLPRKA DFSAVGTIGR
1620 RRANGSVAPQ ERSHNVIEVA TDAPLRKPGG YFAAPAQPDP DDQFIIPPEL EEEVKEIMKH
1680 HQEQQQQQQP PPPPQLQPQL PRHYQLDQLP DYYDTPL
Download this sequence
in fasta format
Download all sequences for 3.1.3.16
in fasta format
in csv (Excel, OpenOffice) format
Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
74599
Nusbaum C.,Zody M.C.,Borowsky M.L.,Kamal M.,Kodira C.D.,Taylor T.D.,Whittaker C.A.,Chang J.L.,Cuomo C.A.,Dewar K.,FitzGerald M.G.,Yang X.,Abouelleil A.,Allen N.R.,Anderson S.,Bloom T.,Bugalter B.,Butler J.,Cook A.,DeCaprio D.,Engels R.,Garber M.,Gnirke A.,Hafez N.,Hall J.L.,Norman C.H.,Itoh T.,Jaffe D.B.,Kuroki Y.,Lehoczky J.,Lui A.,Macdonald P.,Mauceli E.,Mikkelsen T.S.,Naylor J.W.,Nicol R.,Nguyen C.,Noguchi H.,O'Leary S.B.,Piqani B.,Smith C.L.,Talamas J.A.,Topham K.,Totoki Y.,Toyoda A.,Wain H.M.,Young S.K.,Zeng Q.,Zimmer A.R.,Fujiyama A.,Hattori M.,Birren B.W.,Sakaki Y.,Lander E.S.
DNA sequence and analysis of human chromosome 18.
Nature
437
551-555
2005
16177791
74600
Nagase T.,Ishikawa K.,Miyajima N.,Tanaka A.,Kotani H.,Nomura N.,Ohara O.
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
DNA Res.
5
31-39
1998
9628581
74601
Nakajima D.,Okazaki N.,Yamakawa H.,Kikuno R.,Ohara O.,Nagase T.
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
DNA Res.
9
99-106
2002
12168954
74602
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
15489334
74603
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
14702039
74604
Gao T.,Furnari F.,Newton A.C.
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Mol. Cell
18
13-24
2005
15808505
74605
Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Cell
127
635-648
2006
17081983
74606
Brognard J.,Sierecki E.,Gao T.,Newton A.C.
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
Mol. Cell
25
917-931
2007
17386267
74607
Gao T.,Brognard J.,Newton A.C.
The phosphatase PHLPP controls the cellular levels of protein kinase C.
J. Biol. Chem.
283
6300-6311
2008
18162466
74608
Pei H.,Li L.,Fridley B.L.,Jenkins G.D.,Kalari K.R.,Lingle W.,Petersen G.,Lou Z.,Wang L.
FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.
Cancer Cell
16
259-266
2009
19732725
74609
Liu J.,Weiss H.L.,Rychahou P.,Jackson L.N.,Evers B.M.,Gao T.
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis.
Oncogene
28
994-1004
2009
19079341
74610
Qiao M.,Wang Y.,Xu X.,Lu J.,Dong Y.,Tao W.,Stein J.,Stein G.S.,Iglehart J.D.,Shi Q.,Pardee A.B.
Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis.
Mol. Cell
38
512-523
2010
20513427
74611
Li X.,Yang H.,Liu J.,Schmidt M.D.,Gao T.
Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt.
EMBO Rep.
12
818-824
2011
21701506
74612
Liu J.,Stevens P.D.,Li X.,Schmidt M.D.,Gao T.
PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth.
Mol. Cell. Biol.
31
4917-4927
2011
21986499
74613
Molina J.R.,Agarwal N.K.,Morales F.C.,Hayashi Y.,Aldape K.D.,Cote G.,Georgescu M.M.
PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma.
Oncogene
31
1264-1274
2012
21804599
74614
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
22814378
74615
Gangula N.R.,Maddika S.
WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1).
J. Biol. Chem.
288
34545-34554
2013
24145035
74616
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
23186163
74617
Sierecki E.,Newton A.C.
Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase.
Biochemistry
53
3971-3981
2014
24892992
74618
Li X.,Stevens P.D.,Liu J.,Yang H.,Wang W.,Wang C.,Zeng Z.,Schmidt M.D.,Yang M.,Lee E.Y.,Gao T.
PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice.
Gastroenterology
146
1301-1310
2014
24530606
74619
Fatima S.,Wagstaff K.M.,Loveland K.L.,Jans D.A.
Interactome of the negative regulator of nuclear import BRCA1-binding protein 2.
Sci. Rep.
5
9459-9459
2015
25820252