Sequence of PHLD_PSEF5
EC Number:2.3.1.253
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
phloroglucinol synthase
Q4K418
Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
349
38617
Reaction
3 malonyl-CoA = phloroglucinol + 3 CO2 + 3 CoA
Other sequences found for EC No. 2.3.1.253
General information:
Sequence
0 MSTLCLPHVM FPQHKITQQQ MVDHLENLHA DHPRMALAKR MIANTEVNER HLVLPIDELA
60 VHTGFTHRSI VYEREARQMS SAAARQAIEN AGLQISDIRM VIVTSCTGFM MPSLTAHLIN
120 DLALPTSTVQ LPIAQLGCVA GAAAINRAND FARLDARNHV LIVSLEFSSL CYQPDDTKLH
180 AFISAALFGD AVSACVLRAD DQAGGFKIKK TESYFLPKSE HYIKYDVKDT GFHFTLDKAV
240 MNSIKDVAPV MERLNYESFE QNCAHNDFFI FHTGGRKILD ELVMHLDLAS NRVSQSRSSL
300 SEAGNIASVV VFDVLKRQFD SNLNRGDIGL LAAFGPGFTA EMAVGEWTA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
74573
Paulsen I.T.,Press C.M.,Ravel J.,Kobayashi D.Y.,Myers G.S.A.,Mavrodi D.V.,DeBoy R.T.,Seshadri R.,Ren Q.,Madupu R.,Dodson R.J.,Durkin A.S.,Brinkac L.M.,Daugherty S.C.,Sullivan S.A.,Rosovitz M.J.,Gwinn M.L.,Zhou L.,Schneider D.J.,Cartinhour S.W.,Nelson W.C.,Weidman J.,Watkins K.,Tran K.,Khouri H.,Pierson E.A.,Pierson L.S. III,Thomashow L.S.,Loper J.E.
Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5.
Nat. Biotechnol.
23
873-878
2005
74574
Achkar J.,Xian M.,Zhao H.,Frost J.W.
Biosynthesis of phloroglucinol.
J. Am. Chem. Soc.
127
5332-5333
2005
74575
Zha W.,Rubin-Pitel S.B.,Zhao H.
Characterization of the substrate specificity of PhlD, a type III polyketide synthase from Pseudomonas fluorescens.
J. Biol. Chem.
281
32036-32047
2006
74576
Zha W.,Rubin-Pitel S.B.,Zhao H.
Exploiting genetic diversity by directed evolution: molecular breeding of type III polyketide synthases improves productivity.
Mol. Biosyst.
4
246-248
2008
74577
Cao Y.,Jiang X.,Zhang R.,Xian M.
Improved phloroglucinol production by metabolically engineered Escherichia coli.
Appl. Microbiol. Biotechnol.
91
1545-1552
2011
74578
Rao G.,Lee J.K.,Zhao H.
Directed evolution of phloroglucinol synthase PhlD with increased stability for phloroglucinol production.
Appl. Microbiol. Biotechnol.
97
5861-5867
2013
