Sequence of PARE_FRATH
EC Number:5.6.2.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
DNA topoisomerase (ATP-hydrolysing)
A0A0J9WZF0
Francisella tularensis subsp. holarctica (strain LVS)
627
70355
Reaction
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Other sequences found for EC No. 5.6.2.2
General information:
Sequence
0 MQNYNAKSIE VLTGLDPVKK RPGMYTNIEN PNHLIQEIID NSVDEVLAGF ASKINITLYE
60 DNSIEVADDG RGMPVDIHPE HKMSGIELIM TKLHSGGKFS NKNYTHSGGL HGVGVSVVNA
120 LSTRLEAEIK RDGNVYHIVF EDGFKTKDLE IIDNVGKKNT GTKIRFWPNK KYFDDIKVNF
180 KALKNLLEAK AILCKALTIK YSNEIKKEKL TWHFETGLKG YLDHKLEAET LPAEPFIIDN
240 FSNGDSYLDA VFCWCEDLSE SIKNSYVNLI PTPQDGTHVT GLKNGIYDAI KAYIEKNSLS
300 VKNIKITAND SFAQLNYVIS VKITNPQFAG QTKEKLSNKD VTNFVATAVK DLLTIWLNQN
360 PDEARQIVEN ISKVAQKRIN ADKKTTRKRI MNTTIRLPGK LTDCISSDVN STELFIVEGD
420 SAGGSAKQAR DKNFQAVLPL KGKILNSWEL DADTIMNSQE IHNIATAIGV DPDSDDISAL
480 RYNKICILAD ADSDGLHIAT LLCAMFLKHF RKLIENGHIY IAQPPLFRID IGKSTFYALD
540 ENERDTILTK NSKLPGKVNI MRFKGLGEMN PAQLRESAMD VSSRRLLQLT ISDVYDDTEM
600 LDMLLAKKRA KDRRDWLENY GDRASVE
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
72075
Trzoss M.,Bensen D.C.,Li X.,Chen Z.,Lam T.,Zhang J.,Creighton C.J.,Cunningham M.L.,Kwan B.,Stidham M.,Nelson K.,Brown-Driver V.,Castellano A.,Shaw K.J.,Lightstone F.C.,Wong S.E.,Nguyen T.B.,Finn J.,Tari L.W.
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity.
Bioorg. Med. Chem. Lett.
23
1537-1543
2013
72076
Tari L.W.,Trzoss M.,Bensen D.C.,Li X.,Chen Z.,Lam T.,Zhang J.,Creighton C.J.,Cunningham M.L.,Kwan B.,Stidham M.,Shaw K.J.,Lightstone F.C.,Wong S.E.,Nguyen T.B.,Nix J.,Finn J.
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg. Med. Chem. Lett.
23
1529-1536
2013
72077
Tari L.W.,Li X.,Trzoss M.,Bensen D.C.,Chen Z.,Lam T.,Zhang J.,Lee S.J.,Hough G.,Phillipson D.,Akers-Rodriguez S.,Cunningham M.L.,Kwan B.P.,Nelson K.J.,Castellano A.,Locke J.B.,Brown-Driver V.,Murphy T.M.,Ong V.S.,Pillar C.M.,Shinabarger D.L.,Nix J.,Lightstone F.C.,Wong S.E.,Nguyen T.B.,Shaw K.J.,Finn J.
Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents.
PLoS ONE
8
0-0
2013
