Sequence of CP4F4_RAT
EC Number:1.14.14.94
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
Other sequences found for EC No. 1.14.14.94
General information:
Sequence
0 MPQLDLSWLG LRLETSLPWL LLLLIGASWL LVRVLTQTYI FYRTYQHLCD FPQPPKWNWF
60 LGHLGMITPT EQGLKQVTKL VATYPQGFMT WLGPILPIIT LCHPDVIRSV LSASASVALK
120 EVIFYSFLKP WLGDGLLLSD GDKWSCHRRM LTPAFHFNIL KPYVKIFNDS TNIMHAKWQD
180 LASGGSARLD MFKNISLMTL DSLQKCVFSF DSNCQEKPSE YISAILELSA LVAKRYQQLL
240 LHTDSLYQLT HNGRRFHKAC KLVHNFTDAV IQGRRRALPS QHEDDILKAK ARSKTLDFID
300 VLLLTKDEDG KELSDEDIRA EADTFMFEGH DTTASGLSWI LYNLARHPEY QERCRQEVRE
360 LLRDRESTEI EWDDLAQLPF LTMCIKESLR LHPPVTVISR RCTQDIVLPD GRVIPKGVIC
420 IINIFATHHN PTVWPDPEVY DPFRFDPENI KDRSPLAFIP FSAGPRNCIG QTFAMNEMKV
480 ALALTLLRFR VLPDDKEPRR KPELILRAEG GLWLRVEPLS TQ
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
784056
Kawashima H.,Strobel H.W.
cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily.
Biochem. Biophys. Res. Commun.
217
1137-1144
1995
784057
Kawashima H.,Kusunose E.,Thompson C.M.,Strobel H.W.
Protein expression, characterization, and regulation of CYP4F4 and CYP4F5 cloned from rat brain.
Arch. Biochem. Biophys.
347
148-154
1997
784058
LeBrun L.A.,Xu F.,Kroetz D.L.,Ortiz de Montellano P.R.
Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family.
Biochemistry
41
5931-5937
2002
784059
Xu F.,Falck J.R.,Ortiz de Montellano P.R.,Kroetz D.L.
Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes.
J. Pharmacol. Exp. Ther.
308
887-895
2004
784060
Kalsotra A.,Anakk S.,Brommer C.L.,Kikuta Y.,Morgan E.T.,Strobel H.W.
Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytes.
Arch. Biochem. Biophys.
461
104-112
2007
