Sequence of CHKA_HUMAN
EC Number:2.7.1.32
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + choline = ADP + phosphocholine
Other sequences found for EC No. 2.7.1.32
General information:
Sequence
0 MKTKFCTGGE AEPSPLGLLL SCGSGSAAPA PGVGQQRDAA SDLESKQLGG QQPPLALPPP
60 PPLPLPLPLP QPPPPQPPAD EQPEPRTRRR AYLWCKEFLP GAWRGLREDE FHISVIRGGL
120 SNMLFQCSLP DTTATLGDEP RKVLLRLYGA ILQMRSCNKE GSEQAQKENE FQGAEAMVLE
180 SVMFAILAER SLGPKLYGIF PQGRLEQFIP SRRLDTEELS LPDISAEIAE KMATFHGMKM
240 PFNKEPKWLF GTMEKYLKEV LRIKFTEESR IKKLHKLLSY NLPLELENLR SLLESTPSPV
300 VFCHNDCQEG NILLLEGREN SEKQKLMLID FEYSSYNYRG FDIGNHFCEW MYDYSYEKYP
360 FFRANIRKYP TKKQQLHFIS SYLPAFQNDF ENLSTEEKSI IKEEMLLEVN RFALASHFLW
420 GLWSIVQAKI SSIEFGYMDY AQARFDAYFH QKRKLGV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
780477
Hosaka K.,Tanaka S.,Nikawa J.,Yamashita S.
Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation.
FEBS Lett.
304
229-232
1992
780478
Taylor T.D.,Noguchi H.,Totoki Y.,Toyoda A.,Kuroki Y.,Dewar K.,Lloyd C.,Itoh T.,Takeda T.,Kim D.-W.,She X.,Barlow K.F.,Bloom T.,Bruford E.,Chang J.L.,Cuomo C.A.,Eichler E.,FitzGerald M.G.,Jaffe D.B.,LaButti K.,Nicol R.,Park H.-S.,Seaman C.,Sougnez C.,Yang X.,Zimmer A.R.,Zody M.C.,Birren B.W.,Nusbaum C.,Fujiyama A.,Hattori M.,Rogers J.,Lander E.S.,Sakaki Y.
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Nature
440
497-500
2006
780479
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
780480
Gallego-Ortega D.,Ramirez de Molina A.,Ramos M.A.,Valdes-Mora F.,Barderas M.G.,Sarmentero-Estrada J.,Lacal J.C.
Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment.
PLoS ONE
4
0-0
2009
780481
Wong M.T.,Chen S.S.
Hepatitis C Virus Subverts Human Choline Kinase-alpha To Bridge Phosphatidylinositol-4-Kinase IIIalpha (PI4KIIIalpha) and NS5A and Upregulates PI4KIIIalpha Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication.
J. Virol.
91
0-0
2017
780482
Liu R.,Lee J.H.,Li J.,Yu R.,Tan L.,Xia Y.,Zheng Y.,Bian X.L.,Lorenzi P.L.,Chen Q.,Lu Z.
Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.
Mol. Cell
81
2722-2735
2021
780483
Malito E.,Sekulic N.,Too W.C.,Konrad M.,Lavie A.
Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine.
J. Mol. Biol.
364
136-151
2006
780484
Hong B.S.,Allali-Hassani A.,Tempel W.,Finerty P.J. Jr.,Mackenzie F.,Dimov S.,Vedadi M.,Park H.W.
Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
J. Biol. Chem.
285
16330-16340
2010
