Sequence of CDC42_HUMAN
EC Number:3.6.5.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
GTP + H2O = GDP + phosphate
Other sequences found for EC No. 3.6.5.2
General information:
Sequence
0 MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG
60 QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCPKTPF LLVGTQIDLR
120 DDPSTIEKLA KNKQKPITPE TAEKLARDLK AVKYVECSAL TQKGLKNVFD EAILAALEPP
180 EPKKSRRCVL L
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
778836
Munemitsu S.,Innis M.A.,Clark R.,McCormick F.,Ullrich A.,Polakis P.
Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42.
Mol. Cell. Biol.
10
5977-5982
1990
778837
Shinjo K.,Koland J.G.,Hart M.J.,Narasimhan V.,Johnson D.I.,Evans T.,Cerione R.A.
Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42.
Proc. Natl. Acad. Sci. U.S.A.
87
9853-9857
1990
778841
Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.
The DNA sequence and biological annotation of human chromosome 1.
Nature
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2006
778842
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
778844
Kwong C.H.,Malech H.L.,Rotrosen D.,Leto T.L.
Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins.
Biochemistry
32
5711-5717
1993
778845
Polakis P.G.,Snyderman R.,Evans T.
Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain.
Biochem. Biophys. Res. Commun.
160
25-32
1989
778846
Adra C.N.,Ko J.,Leonard D.,Wirth L.J.,Cerione R.A.,Lim B.
Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I.
Genes Chromosomes Cancer
8
253-261
1993
778847
Just I.,Selzer J.,Wilm M.,von Eichel-Streiber C.,Mann M.,Aktories K.
Glucosylation of Rho proteins by Clostridium difficile toxin B.
Nature
375
500-503
1995
778848
Just I.,Wilm M.,Selzer J.,Rex G.,von Eichel-Streiber C.,Mann M.,Aktories K.
The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins.
J. Biol. Chem.
270
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1995
778849
Selzer J.,Hofmann F.,Rex G.,Wilm M.,Mann M.,Just I.,Aktories K.
Clostridium novyi alpha-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteins.
J. Biol. Chem.
271
25173-25177
1996
778850
Joberty G.,Perlungher R.R.,Macara I.G.
The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins.
Mol. Cell. Biol.
19
6585-6597
1999
778851
Eisenmann K.M.,McCarthy J.B.,Simpson M.A.,Keely P.J.,Guan J.-L.,Tachibana K.,Lim L.,Manser E.,Furcht L.T.,Iida J.
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
Nat. Cell Biol.
1
507-513
1999
778852
Pirone D.M.,Fukuhara S.,Gutkind J.S.,Burbelo P.D.
SPECs, small binding proteins for Cdc42.
J. Biol. Chem.
275
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2000
778853
Johansson A.-S.,Driessens M.,Aspenstroem P.
The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1.
J. Cell Sci.
113
3267-3275
2000
778854
Miki H.,Yamaguchi H.,Suetsugu S.,Takenawa T.
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.
Nature
408
732-735
2000
778855
Noda Y.,Takeya R.,Ohno S.,Naito S.,Ito T.,Sumimoto H.
Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.
Genes Cells
6
107-119
2001
778856
Degani S.,Balzac F.,Brancaccio M.,Guazzone S.,Retta S.F.,Silengo L.,Eva A.,Tarone G.
The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading.
J. Cell Biol.
156
377-387
2002
778857
Meller N.,Irani-Tehrani M.,Kiosses W.B.,Del Pozo M.A.,Schwartz M.A.
Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins.
Nat. Cell Biol.
4
639-647
2002
778858
Tu S.,Wu W.J.,Wang J.,Cerione R.A.
Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase.
J. Biol. Chem.
278
49293-49300
2003
778859
Masuda-Robens J.M.,Kutney S.N.,Qi H.,Chou M.M.
The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.
Mol. Cell. Biol.
23
2151-2161
2003
778860
Gauthier-Campbell C.,Bredt D.S.,Murphy T.H.,El-Husseini A.
Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.
Mol. Biol. Cell
15
2205-2217
2004
778861
Oceguera-Yanez F.,Kimura K.,Yasuda S.,Higashida C.,Kitamura T.,Hiraoka Y.,Haraguchi T.,Narumiya S.
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.
J. Cell Biol.
168
221-232
2005
778862
Modzelewska K.,Newman L.P.,Desai R.,Keely P.J.
Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.
J. Biol. Chem.
281
37527-37535
2006
778863
Shibata S.,Nagase M.,Yoshida S.,Kawarazaki W.,Kurihara H.,Tanaka H.,Miyoshi J.,Takai Y.,Fujita T.
Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.
Nat. Med.
14
1370-1376
2008
778864
Worby C.A.,Mattoo S.,Kruger R.P.,Corbeil L.B.,Koller A.,Mendez J.C.,Zekarias B.,Lazar C.,Dixon J.E.
The fic domain: regulation of cell signaling by adenylylation.
Mol. Cell
34
93-103
2009
778865
Giuliani C.,Troglio F.,Bai Z.,Patel F.B.,Zucconi A.,Malabarba M.G.,Disanza A.,Stradal T.B.,Cassata G.,Confalonieri S.,Hardin J.D.,Soto M.C.,Grant B.D.,Scita G.
Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.
PLoS Genet.
5
0-0
2009
778866
Yarbrough M.L.,Li Y.,Kinch L.N.,Grishin N.V.,Ball H.L.,Orth K.
AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.
Science
323
269-272
2009
778867
Vaz Meirelles G.,Ferreira Lanza D.C.,da Silva J.C.,Santana Bernachi J.,Paes Leme A.F.,Kobarg J.
Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.
J. Proteome Res.
9
6298-6316
2010
778868
Naji L.,Pacholsky D.,Aspenstrom P.
ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion.
Biochem. Biophys. Res. Commun.
409
96-102
2011
778869
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
778870
Oliver A.W.,He X.,Borthwick K.,Donne A.J.,Hampson L.,Hampson I.N.
The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.
Br. J. Cancer
104
324-331
2011
778871
Dubash A.D.,Koetsier J.L.,Amargo E.V.,Najor N.A.,Harmon R.M.,Green K.J.
The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1.
J. Cell Biol.
202
653-666
2013
778872
Gupta I.R.,Baldwin C.,Auguste D.,Ha K.C.,El Andalousi J.,Fahiminiya S.,Bitzan M.,Bernard C.,Akbari M.R.,Narod S.A.,Rosenblatt D.S.,Majewski J.,Takano T.
ARHGDIA: a novel gene implicated in nephrotic syndrome.
J. Med. Genet.
50
330-338
2013
778873
Jank T.,Bogdanovic X.,Wirth C.,Haaf E.,Spoerner M.,Boehmer K.E.,Steinemann M.,Orth J.H.,Kalbitzer H.R.,Warscheid B.,Hunte C.,Aktories K.
A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.
Nat. Struct. Mol. Biol.
20
1273-1280
2013
778874
Genth H.,Pauillac S.,Schelle I.,Bouvet P.,Bouchier C.,Varela-Chavez C.,Just I.,Popoff M.R.
Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.
Cell. Microbiol.
16
1706-1721
2014
778875
Schlam D.,Bagshaw R.D.,Freeman S.A.,Collins R.F.,Pawson T.,Fairn G.D.,Grinstein S.
Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.
Nat. Commun.
6
8623-8623
2015
778876
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
778877
Majmundar A.J.,Buerger F.,Forbes T.A.,Klaembt V.,Schneider R.,Deutsch K.,Kitzler T.M.,Howden S.E.,Scurr M.,Tan K.S.,Krzeminski M.,Widmeier E.,Braun D.A.,Lai E.,Ullah I.,Amar A.,Kolb A.,Eddy K.,Chen C.H.,Salmanullah D.,Dai R.,Nakayama M.,Ottlewski I.,Kolvenbach C.M.,Onuchic-Whitford A.C.,Mao Y.,Mann N.,Nabhan M.M.,Rosen S.,Forman-Kay J.D.,Soliman N.A.,Heilos A.,Kain R.,Aufricht C.,Mane S.,Lifton R.P.,Shril S.,Little M.H.,Hildebrandt F.
Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice.
Sci. Adv.
7
0-0
2021
778878
Feltham J.L.,Dotsch V.,Raza S.,Manor D.,Cerione R.A.,Sutcliffe M.J.,Wagner G.,Oswald R.E.
Definition of the switch surface in the solution structure of Cdc42Hs.
Biochemistry
36
8755-8766
1997
778879
Guo W.,Sutcliffe M.J.,Cerione R.A.,Oswald R.E.
Identification of the binding surface on Cdc42Hs for p21-activated kinase.
Biochemistry
37
14030-14037
1998
778880
Rittinger K.,Walker P.A.,Eccleston J.F.,Nurmahomed K.,Owen D.,Laue E.,Gamblin S.J.,Smerdon S.J.
Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.
Nature
388
693-697
1997
778881
Rudolph M.G.,Wittinghofer A.,Vetter I.R.
Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal.
Protein Sci.
8
778-787
1999
778883
Hoffman G.R.,Nassar N.,Cerione R.A.
Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI.
Cell
100
345-356
2000
778884
Yang J.,Zhang Z.,Roe S.M.,Marshall C.J.,Barford D.
Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.
Science
325
1398-1402
2009
778885
Xiao J.,Worby C.A.,Mattoo S.,Sankaran B.,Dixon J.E.
Structural basis of Fic-mediated adenylylation.
Nat. Struct. Mol. Biol.
17
1004-1010
2010
778886
Harada Y.,Tanaka Y.,Terasawa M.,Pieczyk M.,Habiro K.,Katakai T.,Hanawa-Suetsugu K.,Kukimoto-Niino M.,Nishizaki T.,Shirouzu M.,Duan X.,Uruno T.,Nishikimi A.,Sanematsu F.,Yokoyama S.,Stein J.V.,Kinashi T.,Fukui Y.
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
Blood
119
4451-4461
2012
778887
Takenouchi T.,Kosaki R.,Niizuma T.,Hata K.,Kosaki K.
Macrothrombocytopenia and developmental delay with a de novo CDC42 mutation: Yet another locus for thrombocytopenia and developmental delay.
Am. J. Med. Genet. A
167A
2822-2825
2015
778888
Takenouchi T.,Okamoto N.,Ida S.,Uehara T.,Kosaki K.
Further evidence of a mutation in CDC42 as a cause of a recognizable syndromic form of thrombocytopenia.
Am. J. Med. Genet. A
170
852-855
2016
