Sequence of FMO3_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
trimethylamine monooxygenase
P31513
Homo sapiens
532
60033
Reaction
N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MGKKVAIIGA GVSGLASIRS CLEEGLEPTC FEKSNDIGGL WKFSDHAEEG RASIYKSVFS
 60 NSSKEMMCFP DFPFPDDFPN FMHNSKIQEY IIAFAKEKNL LKYIQFKTFV SSVNKHPDFA
120 TTGQWDVTTE RDGKKESAVF DAVMVCSGHH VYPNLPKESF PGLNHFKGKC FHSRDYKEPG
180 VFNGKRVLVV GLGNSGCDIA TELSRTAEQV MISSRSGSWV MSRVWDNGYP WDMLLVTRFG
240 TFLKNNLPTA ISDWLYVKQM NARFKHENYG LMPLNGVLRK EPVFNDELPA SILCGIVSVK
300 PNVKEFTETS AIFEDGTIFE GIDCVIFATG YSFAYPFLDE SIIKSRNNEI ILFKGVFPPL
360 LEKSTIAVIG FVQSLGAAIP TVDLQSRWAA QVIKGTCTLP SMEDMMNDIN EKMEKKRKWF
420 GKSETIQTDY IVYMDELSSF IGAKPNIPWL FLTDPKLAME VYFGPCSPYQ FRLVGPGQWP
480 GARNAILTQW DRSLKPMQTR VVGRLQKPCF FFHWLKLFAI PILLIAVFLV LT
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
773829
Lomri N.,Gu Q.,Cashman J.R.
Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver.
Proc. Natl. Acad. Sci. U.S.A.
89
1685-1689
1992
773830
Dolphin C.T.,Cullingford T.E.,Shephard E.A.,Smith R.L.,Phillips I.R.
Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04.
Eur. J. Biochem.
235
683-689
1996
773831
Dolphin C.T.,Riley J.H.,Smith R.L.,Shephard E.A.,Phillips I.R.
Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA.
Genomics
46
260-267
1997
773833
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
773834
Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.
The DNA sequence and biological annotation of human chromosome 1.
Nature
441
315-321
2006
773836
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
773837
Haining R.L.,Hunter A.P.,Sadeque A.J.,Philpot R.M.,Rettie A.E.
Baculovirus-mediated expression and purification of human FMO3: catalytic, immunochemical, and structural characterization.
Drug Metab. Dispos.
25
790-797
1997
773838
Lang D.H.,Yeung C.K.,Peter R.M.,Ibarra C.,Gasser R.,Itagaki K.,Philpot R.M.,Rettie A.E.
Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3.
Biochem. Pharmacol.
56
1005-1012
1998
773839
Treacy E.P.,Akerman B.R.,Chow L.M.L.,Youil R.,Bibeau C.,Lin J.,Bruce A.G.,Knight M.,Danks D.M.,Cashman J.R.,Forrest S.M.
Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication.
Hum. Mol. Genet.
7
839-845
1998
773840
Rawden H.C.,Kokwaro G.O.,Ward S.A.,Edwards G.
Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes.
Br. J. Clin. Pharmacol.
49
313-322
2000
773841
Yeung C.K.,Adman E.T.,Rettie A.E.
Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria.
Arch. Biochem. Biophys.
464
251-259
2007
773842
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
773843
Zhu W.,Buffa J.A.,Wang Z.,Warrier M.,Schugar R.,Shih D.M.,Gupta N.,Gregory J.C.,Org E.,Fu X.,Li L.,DiDonato J.A.,Lusis A.J.,Brown J.M.,Hazen S.L.
Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk.
J. Thromb. Haemost.
16
1857-1872
2018
773844
Perez-Paramo Y.X.,Chen G.,Ashmore J.H.,Watson C.J.W.,Nasrin S.,Adams-Haduch J.,Wang R.,Gao Y.T.,Koh W.P.,Yuan J.M.,Lazarus P.
Nicotine-N'-oxidation by flavin monooxygenase enzymes.
Cancer Epidemiol. Biomarkers Prev.
28
311-320
2019
773845
Akerman B.R.,Forrest S.M.,Chow L.M.L.,Youil R.,Knight M.,Treacy E.P.
Two novel mutations of the FMO3 gene in a proband with trimethylaminuria.
Hum. Mutat.
13
376-379
1999
773846
Akerman B.R.,Lemass H.,Chow L.M.L.,Lambert D.M.,Greenberg C.,Bibeau C.,Mamer O.A.,Treacy E.P.
Trimethylaminuria is caused by mutations of the FMO3 gene in a North American cohort.
Mol. Genet. Metab.
68
24-31
1999
773847
Dolphin C.T.,Janmohamed A.,Smith R.L.,Shephard E.A.,Phillips I.R.
Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FM03) gene in patients with fish-odour syndrome.
Pharmacogenetics
10
799-807
2000
773848
Furnes B.,Feng J.,Sommer S.S.,Schlenk D.
Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.
Drug Metab. Dispos.
31
187-193
2003
773849
Fujieda M.,Yamazaki H.,Togashi M.,Saito T.,Kamataki T.
Two novel single nucleotide polymorphisms (SNPs) of the FMO3 gene in Japanese.
Drug Metab. Pharmacokinet.
18
333-335
2003
773850
Zhang J.,Tran Q.,Lattard V.,Cashman J.R.
Deleterious mutations in the flavin-containing monooxygenase 3 (FMO3) gene causing trimethylaminuria.
Pharmacogenetics
13
495-500
2003
773851
Koukouritaki S.B.,Poch M.T.,Henderson M.C.,Siddens L.K.,Krueger S.K.,VanDyke J.E.,Williams D.E.,Pajewski N.M.,Wang T.,Hines R.N.
Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants.
J. Pharmacol. Exp. Ther.
320
266-273
2007