Sequence of NOTUM_HUMAN
EC Number:3.1.1.98
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine + H2O = [Wnt]-L-serine + (9Z)-hexadec-9-enoate
Other sequences found for EC No. 3.1.1.98
General information:
Sequence
0 MGRGVRVLLL LSLLHCAGGS EGRKTWRRRG QQPPPPPRTE AAPAAGQPVE SFPLDFTAVE
60 GNMDSFMAQV KSLAQSLYPC SAQQLNEDLR LHLLLNTSVT CNDGSPAGYY LKESRGSRRW
120 LLFLEGGWYC FNRENCDSRY DTMRRLMSSR DWPRTRTGTG ILSSQPEENP YWWNANMVFI
180 PYCSSDVWSG ASSKSEKNEY AFMGALIIQE VVRELLGRGL SGAKVLLLAG SSAGGTGVLL
240 NVDRVAEQLE KLGYPAIQVR GLADSGWFLD NKQYRHTDCV DTITCAPTEA IRRGIRYWNG
300 VVPERCRRQF QEGEEWNCFF GYKVYPTLRC PVFVVQWLFD EAQLTVDNVH LTGQPVQEGL
360 RLYIQNLGRE LRHTLKDVPA SFAPACLSHE IIIRSHWTDV QVKGTSLPRA LHCWDRSLHD
420 SHKASKTPLK GCPVHLVDSC PWPHCNPSCP TVRDQFTGQE MNVAQFLMHM GFDMQTVAQP
480 QGLEPSELLG MLSNGS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
67032
Zody M.C.,Garber M.,Adams D.J.,Sharpe T.,Harrow J.,Lupski J.R.,Nicholson C.,Searle S.M.,Wilming L.,Young S.K.,Abouelleil A.,Allen N.R.,Bi W.,Bloom T.,Borowsky M.L.,Bugalter B.E.,Butler J.,Chang J.L.,Chen C.-K.,Cook A.,Corum B.,Cuomo C.A.,de Jong P.J.,DeCaprio D.,Dewar K.,FitzGerald M.,Gilbert J.,Gibson R.,Gnerre S.,Goldstein S.,Grafham D.V.,Grocock R.,Hafez N.,Hagopian D.S.,Hart E.,Norman C.H.,Humphray S.,Jaffe D.B.,Jones M.,Kamal M.,Khodiyar V.K.,LaButti K.,Laird G.,Lehoczky J.,Liu X.,Lokyitsang T.,Loveland J.,Lui A.,Macdonald P.,Major J.E.,Matthews L.,Mauceli E.,McCarroll S.A.,Mihalev A.H.,Mudge J.,Nguyen C.,Nicol R.,O'Leary S.B.,Osoegawa K.,Schwartz D.C.,Shaw-Smith C.,Stankiewicz P.,Steward C.,Swarbreck D.,Venkataraman V.,Whittaker C.A.,Yang X.,Zimmer A.R.,Bradley A.,Hubbard T.,Birren B.W.,Rogers J.,Lander E.S.,Nusbaum C.
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Nature
440
1045-1049
2006
67033
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
67035
Giraldez A.J.,Copley R.R.,Cohen S.M.
HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient.
Dev. Cell
2
667-676
2002
67036
Torisu Y.,Watanabe A.,Nonaka A.,Midorikawa Y.,Makuuchi M.,Shimamura T.,Sugimura H.,Niida A.,Akiyama T.,Iwanari H.,Kodama T.,Zeniya M.,Aburatani H.
Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF.
Cancer Sci.
99
1139-1146
2008
67037
Tagliabracci V.S.,Wiley S.E.,Guo X.,Kinch L.N.,Durrant E.,Wen J.,Xiao J.,Cui J.,Nguyen K.B.,Engel J.L.,Coon J.J.,Grishin N.,Pinna L.A.,Pagliarini D.J.,Dixon J.E.
A single kinase generates the majority of the secreted phosphoproteome.
Cell
161
1619-1632
2015
67038
Kakugawa S.,Langton P.F.,Zebisch M.,Howell S.A.,Chang T.H.,Liu Y.,Feizi T.,Bineva G.,O'Reilly N.,Snijders A.P.,Jones E.Y.,Vincent J.P.
Notum deacylates Wnt proteins to suppress signalling activity.
Nature
519
187-192
2015
