Sequence of TIGAR_HUMAN
EC Number:3.1.3.46
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
Other sequences found for EC No. 3.1.3.46
General information:
Sequence
show sequence in normal format
>Q9NQ88|fructose-2,6-bisphosphate 2-phosphatase|EC 3.1.3.46|Homo sapiens|Swiss-Prot
MARFALTVVRHGETRFNKEKIIQGQGVDEPLSETGFKQAAAAGIFLNNVKFTHAFSSDLM
RTKQTMHGILERSKFCKDMTVKYDSRLRERKYGVVEGKALSELRAMAKAAREECPVFTPP
GGETLDQVKMRGIDFFEFLCQLILKEADQKEQFSQGSPSNCLETSLAEIFPLGKNHSSKV
NSDSGIPGLAASVLVVSHGAYMRSLFDYFLTDLKCSLPATLSRSELMSVTPNTGMSLFII
NFEEGREVKPTVQCICMNLQDHLNGLTETR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
746188
White K.E.,Evans W.E.,O'Riordan J.L.H.,Speer M.C.,Econs M.J.,Lorenz-Depiereux B.,Grabowski M.,Meitinger T.,Strom T.M.
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23.
Nat. Genet.
26
345-348
2000
746190
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
746192
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
746193
Jen K.Y.,Cheung V.G.
Identification of novel p53 target genes in ionizing radiation response.
Cancer Res.
65
7666-7673
2005
746194
Bensaad K.,Tsuruta A.,Selak M.A.,Vidal M.N.,Nakano K.,Bartrons R.,Gottlieb E.,Vousden K.H.
TIGAR, a p53-inducible regulator of glycolysis and apoptosis.
Cell
126
107-120
2006
746195
Matsuoka S.,Ballif B.A.,Smogorzewska A.,McDonald E.R. III,Hurov K.E.,Luo J.,Bakalarski C.E.,Zhao Z.,Solimini N.,Lerenthal Y.,Shiloh Y.,Gygi S.P.,Elledge S.J.
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Science
316
1160-1166
2007
746196
Bensaad K.,Cheung E.C.,Vousden K.H.
Modulation of intracellular ROS levels by TIGAR controls autophagy.
EMBO J.
28
3015-3026
2009
746197
Li H.,Jogl G.
Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator).
J. Biol. Chem.
284
1748-1754
2009
746198
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
746199
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
746200
Won K.Y.,Lim S.J.,Kim G.Y.,Kim Y.W.,Han S.A.,Song J.Y.,Lee D.K.
Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer.
Hum. Pathol.
43
221-228
2012
746201
Wanka C.,Steinbach J.P.,Rieger J.
Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis.
J. Biol. Chem.
287
33436-33446
2012
746202
Cheung E.C.,Ludwig R.L.,Vousden K.H.
Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death.
Proc. Natl. Acad. Sci. U.S.A.
109
20491-20496
2012
746203
Ye L.,Zhao X.,Lu J.,Qian G.,Zheng J.C.,Ge S.
Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells.
Biochem. Biophys. Res. Commun.
437
300-306
2013
746204
Cheung E.C.,Athineos D.,Lee P.,Ridgway R.A.,Lambie W.,Nixon C.,Strathdee D.,Blyth K.,Sansom O.J.,Vousden K.H.
TIGAR is required for efficient intestinal regeneration and tumorigenesis.
Dev. Cell
25
463-477
2013
746205
Yu H.P.,Xie J.M.,Li B.,Sun Y.H.,Gao Q.G.,Ding Z.H.,Wu H.R.,Qin Z.H.
TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway.
Sci. Rep.
5
9853-9853
2015
