Sequence of NEP_HUMAN

neprilysin

P08473

750

85514

65579

Letarte M.,Vera S.,Tran R.,Addis J.B.L.,Onizuka R.J.,Quackenbush E.J.,Jongeneel C.V.,McInnes R.R.

Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase.

J. Exp. Med.

168

1247-1253

1988

65580

Shipp M.A.,Richardson N.E.,Sayre P.H.,Brown N.R.,Masteller E.L.,Clayton L.K.,Ritz J.,Reinherz E.L.

Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein.

Proc. Natl. Acad. Sci. U.S.A.

85

4819-4823

1988

65581

D'Adamio L.,Shipp M.A.,Masteller E.L.,Reinherz E.L.

Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions.

Proc. Natl. Acad. Sci. U.S.A.

86

7103-7107

1989

65582

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

65585

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

65586

Malfroy B.,Kuang W.-J.,Seeburg P.H.,Mason A.J.,Schofield P.R.

Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase).

FEBS Lett.

229

206-210

1988

65587

Gafford J.T.,Skidgel R.A.,Erdoes E.G.,Hersh L.B.

Human kidney 'enkephalinase', a neutral metalloendopeptidase that cleaves active peptides.

Biochemistry

22

3265-3271

1983

65588

Skidgel R.A.,Engelbrecht S.,Johnson A.R.,Erdoes E.G.

Hydrolysis of substance p and neurotensin by converting enzyme and neutral endopeptidase.

Peptides

5

769-776

1984

65589

Vanneste Y.,Michel A.,Dimaline R.,Najdovski T.,Deschodt-Lanckman M.

Hydrolysis of alpha-human atrial natriuretic peptide in vitro by human kidney membranes and purified endopeptidase-24.11. Evidence for a novel cleavage site.

Biochem. J.

254

531-537

1988

65590

Yandle T.G.,Brennan S.O.,Espiner E.A.,Nicholls M.G.,Richards A.M.

Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126).

Peptides

10

891-894

1989

65591

Le Moual H.,Dion N.,Roques B.P.,Crine P.,Boileau G.

Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11.

Eur. J. Biochem.

221

475-480

1994

65592

Zhang H.,Li X.-J.,Martin D.B.,Aebersold R.

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

Nat. Biotechnol.

21

660-666

2003

65593

Rice G.I.,Thomas D.A.,Grant P.J.,Turner A.J.,Hooper N.M.

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism.

Biochem. J.

383

45-51

2004

65594

Brandt I.,Lambeir A.M.,Ketelslegers J.M.,Vanderheyden M.,Scharpe S.,De Meester I.

Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form.

Clin. Chem.

52

82-87

2006

65595

Wisner A.,Dufour E.,Messaoudi M.,Nejdi A.,Marcel A.,Ungeheuer M.-N.,Rougeot C.

Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways.

Proc. Natl. Acad. Sci. U.S.A.

103

17979-17984

2006

65596

Morisaki N.,Moriwaki S.,Sugiyama-Nakagiri Y.,Haketa K.,Takema Y.,Imokawa G.

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses.

J. Biol. Chem.

285

39819-39827

2010

65597

Zheng R.,Horiguchi A.,Iida K.,Lee J.,Shen R.,Goodman O.B. Jr.,Nanus D.M.

Neutral endopeptidase is a myristoylated protein.

Mol. Cell. Biochem.

335

173-180

2010

65598

Sato B.,Katagiri Y.U.,Iijima K.,Yamada H.,Ito S.,Kawasaki N.,Okita H.,Fujimoto J.,Kiyokawa N.

The human CD10 lacking an N-glycan at Asn(628) is deficient in surface expression and neutral endopeptidase activity.

Biochim. Biophys. Acta

1820

1715-1723

2012

65599

Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J. Proteomics

96

253-262

2014

65600

Auer-Grumbach M.,Toegel S.,Schabhuettl M.,Weinmann D.,Chiari C.,Bennett D.L.,Beetz C.,Klein D.,Andersen P.M.,Boehme I.,Fink-Puches R.,Gonzalez M.,Harms M.B.,Motley W.,Reilly M.M.,Renner W.,Rudnik-Schoeneborn S.,Schlotter-Weigel B.,Themistocleous A.C.,Weishaupt J.H.,Ludolph A.C.,Wieland T.,Tao F.,Abreu L.,Windhager R.,Zitzelsberger M.,Strom T.M.,Walther T.,Scherer S.S.,Zuechner S.,Martini R.,Senderek J.

Rare variants in MME, encoding metalloprotease neprilysin, are linked to late-onset autosomal-dominant axonal polyneuropathies.

Am. J. Hum. Genet.

99

607-623

2016

65601

Higuchi Y.,Hashiguchi A.,Yuan J.,Yoshimura A.,Mitsui J.,Ishiura H.,Tanaka M.,Ishihara S.,Tanabe H.,Nozuma S.,Okamoto Y.,Matsuura E.,Ohkubo R.,Inamizu S.,Shiraishi W.,Yamasaki R.,Ohyagi Y.,Kira J.,Oya Y.,Yabe H.,Nishikawa N.,Tobisawa S.,Matsuda N.,Masuda M.,Kugimoto C.,Fukushima K.,Yano S.,Yoshimura J.,Doi K.,Nakagawa M.,Morishita S.,Tsuji S.,Takashima H.

Mutations in MME cause an autosomal-recessive Charcot-Marie-Tooth disease type 2.

Ann. Neurol.

79

659-672

2016

65602

Depondt C.,Donatello S.,Rai M.,Wang F.C.,Manto M.,Simonis N.,Pandolfo M.

MME mutation in dominant spinocerebellar ataxia with neuropathy (SCA43).

Neurol. Genet.

2

0-0

2016

65603

Smith A.I.,Rajapakse N.W.,Kleifeld O.,Lomonte B.,Sikanyika N.L.,Spicer A.J.,Hodgson W.C.,Conroy P.J.,Small D.H.,Kaye D.M.,Parkington H.C.,Whisstock J.C.,Kuruppu S.

N-terminal domain of Bothrops asper Myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin.

Sci. Rep.

6

22413-22413

2016

65604

Smith A.I.,Rajapakse N.W.,Kleifeld O.,Lomonte B.,Sikanyika N.L.,Spicer A.J.,Hodgson W.C.,Conroy P.J.,Small D.H.,Kaye D.M.,Parkington H.C.,Whisstock J.C.,Kuruppu S.

Corrigendum: N-terminal domain of Bothrops asper Myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin.

Sci. Rep.

6

24333-24333

2016

65605

Oefner C.,D'Arcy A.,Hennig M.,Winkler F.K.,Dale G.E.

Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon.

J. Mol. Biol.

296

341-349

2000

65606

Oefner C.,Roques B.P.,Fournie-Zaluski M.-C.,Dale G.E.

Structural analysis of neprilysin with various specific and potent inhibitors.

Acta Crystallogr. D

60

392-396

2004

65607

Oefner C.,Pierau S.,Schulz H.,Dale G.E.

Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV.

Acta Crystallogr. D

63

975-981

2007