Sequence of SPHK1_HUMAN

sphingosine kinase

Q9NYA1

384

42518

739307

Melendez A.J.,Carlos-Dias E.,Gosink M.,Allen J.M.,Takacs L.

Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution.

Gene

251

19-26

2000

739308

Nava V.E.,Lacana' E.,Poulton S.,Liu H.,Sugiura M.,Kono K.,Milstien S.,Kohama T.,Spiegel S.

Functional characterization of human sphingosine kinase-1.

FEBS Lett.

473

81-84

2000

739309

Pitson S.M.,D'Andrea R.J.,Vandeleur L.,Moretti P.A.B.,Xia P.,Gamble J.R.,Vadas M.A.,Wattenberg B.W.

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes.

Biochem. J.

350

429-441

2000

739311

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

739312

Zody M.C.,Garber M.,Adams D.J.,Sharpe T.,Harrow J.,Lupski J.R.,Nicholson C.,Searle S.M.,Wilming L.,Young S.K.,Abouelleil A.,Allen N.R.,Bi W.,Bloom T.,Borowsky M.L.,Bugalter B.E.,Butler J.,Chang J.L.,Chen C.-K.,Cook A.,Corum B.,Cuomo C.A.,de Jong P.J.,DeCaprio D.,Dewar K.,FitzGerald M.,Gilbert J.,Gibson R.,Gnerre S.,Goldstein S.,Grafham D.V.,Grocock R.,Hafez N.,Hagopian D.S.,Hart E.,Norman C.H.,Humphray S.,Jaffe D.B.,Jones M.,Kamal M.,Khodiyar V.K.,LaButti K.,Laird G.,Lehoczky J.,Liu X.,Lokyitsang T.,Loveland J.,Lui A.,Macdonald P.,Major J.E.,Matthews L.,Mauceli E.,McCarroll S.A.,Mihalev A.H.,Mudge J.,Nguyen C.,Nicol R.,O'Leary S.B.,Osoegawa K.,Schwartz D.C.,Shaw-Smith C.,Stankiewicz P.,Steward C.,Swarbreck D.,Venkataraman V.,Whittaker C.A.,Yang X.,Zimmer A.R.,Bradley A.,Hubbard T.,Birren B.W.,Rogers J.,Lander E.S.,Nusbaum C.

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

Nature

440

1045-1049

2006

739314

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

739315

Gijsbers S.,Asselberghs S.,Herdewijn P.,Van Veldhoven P.P.

1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase.

Biochim. Biophys. Acta

1580

1-8

2002

739316

Lacana E.,Maceyka M.,Milstien S.,Spiegel S.

Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity.

J. Biol. Chem.

277

32947-32953

2002

739317

Inagaki Y.,Li P.Y.,Wada A.,Mitsutake S.,Igarashi Y.

Identification of functional nuclear export sequences in human sphingosine kinase 1.

Biochem. Biophys. Res. Commun.

311

168-173

2003

739318

Maceyka M.,Sankala H.,Hait N.C.,Le Stunff H.,Liu H.,Toman R.,Collier C.,Zhang M.,Satin L.S.,Merrill A.H. Jr.,Milstien S.,Spiegel S.

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.

J. Biol. Chem.

280

37118-37129

2005

739319

Leclercq T.M.,Moretti P.A.,Vadas M.A.,Pitson S.M.

Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity.

J. Biol. Chem.

283

9606-9614

2008

739320

Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.

A quantitative atlas of mitotic phosphorylation.

Proc. Natl. Acad. Sci. U.S.A.

105

10762-10767

2008

739321

Jarman K.E.,Moretti P.A.,Zebol J.R.,Pitson S.M.

Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1.

J. Biol. Chem.

285

483-492

2010

739322

Alvarez S.E.,Harikumar K.B.,Hait N.C.,Allegood J.,Strub G.M.,Kim E.Y.,Maceyka M.,Jiang H.,Luo C.,Kordula T.,Milstien S.,Spiegel S.

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.

Nature

465

1084-1088

2010

739323

Adada M.M.,Orr-Gandy K.A.,Snider A.J.,Canals D.,Hannun Y.A.,Obeid L.M.,Clarke C.J.

Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor kappaB activation.

J. Biol. Chem.

288

27667-27679

2013

739324

Shen H.,Giordano F.,Wu Y.,Chan J.,Zhu C.,Milosevic I.,Wu X.,Yao K.,Chen B.,Baumgart T.,Sieburth D.,De Camilli P.

Coupling between endocytosis and sphingosine kinase 1 recruitment.

Nat. Cell Biol.

16

652-662

2014

739325

Lee H.,Lee J.K.,Park M.H.,Hong Y.R.,Marti H.H.,Kim H.,Okada Y.,Otsu M.,Seo E.J.,Park J.H.,Bae J.H.,Okino N.,He X.,Schuchman E.H.,Bae J.S.,Jin H.K.

Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons.

Nat. Commun.

5

5514-5514

2014

739326

Lima S.,Milstien S.,Spiegel S.

Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking.

J. Biol. Chem.

292

3074-3088

2017

739327

Lee J.Y.,Han S.H.,Park M.H.,Baek B.,Song I.S.,Choi M.K.,Takuwa Y.,Ryu H.,Kim S.H.,He X.,Schuchman E.H.,Bae J.S.,Jin H.K.

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.

Nat. Commun.

9

1479-1479

2018

739328

Wang Z.,Min X.,Xiao S.H.,Johnstone S.,Romanow W.,Meininger D.,Xu H.,Liu J.,Dai J.,An S.,Thibault S.,Walker N.

Molecular basis of sphingosine kinase 1 substrate recognition and catalysis.

Structure

21

798-809

2013