Sequence of NAGZ_VIBCH
EC Number:3.2.1.52
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
beta-N-acetylhexosaminidase
Q9KU37
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
330
36466
Reaction
(N-acetyl-D-glucosamine)4 + 3 H2O = 4 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
Other sequences found for EC No. 3.2.1.52
General information:
Sequence
0 MGPLWLDVAG YELSAEDREI LQHPTVGGVI LFGRNYHDNQ QLLALNKAIR QAAKRPILIG
60 VDQEGGRVQR FREGFSRIPP AQYYARAENG VELAEQGGWL MAAELIAHDV DLSFAPVLDM
120 GFACKAIGNR AFGEDVQTVL KHSSAFLRGM KAVGMATTGK HFPGHGAVIA DSHLETPYDE
180 RETIAQDMAI FRAQIEAGVL DAMMPAHVVY PHYDAQPASG SSYWLKQVLR EELGFKGIVF
240 SDDLSMEGAA VMGGPVERSH QALVAGCDMI LICNKREAAV EVLDNLPIME VPQAEALLKK
300 QQFSYSELKR LERWQQASAN MQRLIEQFSE
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
63987
Heidelberg J.F.,Eisen J.A.,Nelson W.C.,Clayton R.A.,Gwinn M.L.,Dodson R.J.,Haft D.H.,Hickey E.K.,Peterson J.D.,Umayam L.A.,Gill S.R.,Nelson K.E.,Read T.D.,Tettelin H.,Richardson D.L.,Ermolaeva M.D.,Vamathevan J.J.,Bass S.,Qin H.,Dragoi I.,Sellers P.,McDonald L.A.,Utterback T.R.,Fleischmann R.D.,Nierman W.C.,White O.,Salzberg S.L.,Smith H.O.,Colwell R.R.,Mekalanos J.J.,Venter J.C.,Fraser C.M.
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.
Nature
406
477-483
2000
63988
Stubbs K.A.,Bacik J.P.,Perley-Robertson G.E.,Whitworth G.E.,Gloster T.M.,Vocadlo D.J.,Mark B.L.
The development of selective inhibitors of NagZ: increased susceptibility of Gram-negative bacteria to beta-lactams.
ChemBioChem
14
1973-1981
2013
63990
Stubbs K.A.,Balcewich M.,Mark B.L.,Vocadlo D.J.
Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance.
J. Biol. Chem.
282
21382-21391
2007
63991
Balcewich M.D.,Stubbs K.A.,He Y.,James T.W.,Davies G.J.,Vocadlo D.J.,Mark B.L.
Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ.
Protein Sci.
18
1541-1551
2009
