Sequence of ROSA_STRDJ
EC Number:2.1.1.343
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
8-amino-8-demethylriboflavin N,N-dimethyltransferase
K4RFM2
Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768)
347
37936
Reaction
2 S-adenosyl-L-methionine + 8-amino-8-demethylriboflavin = 2 S-adenosyl-L-homocysteine + roseoflavin
Other sequences found for EC No. 2.1.1.343
General information:
Sequence
0 MRPEPTEHPE RTAAQRLYQY NVDLKVAFVL YAVAKLHLPD LLADGPRTTA DLAAATGSDP
60 SRLRRLLRAA AGADALREVP EDSFELAPMG DLLRSGHPRS MRGMTTFFAE PDVLAAYGDL
120 VESVRTGVPA FQLRHREPLY DFLARPQHKE VRDEFDAAMV EFGQYFADDF LTSFDFGRFT
180 RFADIGGGRG QFLAGVLTAV PSSTGVLVDG PAVAASAHKF LASQNLTERV EVRIGDFFDV
240 LPTGCDAYVL RGVLEDWADA DAVRLLVRIR QAMGDAPEAR LLILDSVIGE TGELGKVLDL
300 DMLVLVEGEH RTRAQWDDLL ARAGFDIVGI HPAGDVWAVI ECRGTAG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
728461
Jankowitsch F.,Kuehm C.,Kellner R.,Kalinowski J.,Pelzer S.,Macheroux P.,Mack M.
A novel N,N-8-amino-8-demethyl-D-riboflavin dimethyltransferase (RosA) catalyzing the two terminal steps of roseoflavin biosynthesis in Streptomyces davawensis.
J. Biol. Chem.
286
38275-38285
2011
728462
Jankowitsch F.,Schwarz J.,Ruckert C.,Gust B.,Szczepanowski R.,Blom J.,Pelzer S.,Kalinowski J.,Mack M.
Genome sequence of the bacterium Streptomyces davawensis JCM 4913 and heterologous production of the unique antibiotic roseoflavin.
J. Bacteriol.
194
6818-6827
2012
728463
Tongsook C.,Uhl M.K.,Jankowitsch F.,Mack M.,Gruber K.,Macheroux P.
Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-d-riboflavin to the antibiotic roseoflavin.
FEBS J.
283
1531-1549
2016
