Sequence of PRI1_HUMAN
EC Number:2.7.7.102
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ssDNA + n dNTP = ssDNA/pppdN(pdN)n-1 hybrid + (n-1) diphosphate
Other sequences found for EC No. 2.7.7.102
General information:
Sequence
0 METFDPTELP ELLKLYYRRL FPYSQYYRWL NYGGVIKNYF QHREFSFTLK DDIYIRYQSF
60 NNQSDLEKEM QKMNPYKIDI GAVYSHRPNQ HNTVKLGAFQ AQEKELVFDI DMTDYDDVRR
120 CCSSADICPK CWTLMTMAIR IIDRALKEDF GFKHRLWVYS GRRGVHCWVC DESVRKLSSA
180 VRSGIVEYLS LVKGGQDVKK KVHLSEKIHP FIRKSINIIK KYFEEYALVN QDILENKESW
240 DKILALVPET IHDELQQSFQ KSHNSLQRWE HLKKVASRYQ NNIKNDKYGP WLEWEIMLQY
300 CFPRLDINVS KGINHLLKSP FSVHPKTGRI SVPIDLQKVD QFDPFTVPTI SFICRELDAI
360 STNEEEKEEN EAESDVKHRT RDYKKTSLAP YVKVFEHFLE NLDKSRKGEL LKKSDLQKDF
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
715995
Stadlbauer F.,Brueckner A.,Rehfuess C.,Eckerskorn C.,Lottspeich F.,Foerster V.,Tseng B.Y.,Nasheuer H.-P.
DNA replication in vitro by recombinant DNA-polymerase-alpha-primase.
Eur. J. Biochem.
222
781-793
1994
715996
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
715997
Cloutier S.,Hamel H.,Champagne M.,Yotov W.V.
Mapping of the human DNA primase 1 (PRIM1) to chromosome 12q13.
Genomics
43
398-401
1997
715998
Schneider A.,Smith R.W.,Kautz A.R.,Weisshart K.,Grosse F.,Nasheuer H.P.
Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit.
J. Biol. Chem.
273
21608-21615
1998
715999
Weiner B.E.,Huang H.,Dattilo B.M.,Nilges M.J.,Fanning E.,Chazin W.J.
An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase.
J. Biol. Chem.
282
33444-33451
2007
716000
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
716001
Bienvenut W.V.,Sumpton D.,Martinez A.,Lilla S.,Espagne C.,Meinnel T.,Giglione C.
Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
Mol. Cell. Proteomics
11
0-0
2012
716002
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
716003
Kilkenny M.L.,Longo M.A.,Perera R.L.,Pellegrini L.
Structures of human primase reveal design of nucleotide elongation site and mode of Pol alpha tethering.
Proc. Natl. Acad. Sci. U.S.A.
110
15961-15966
2013
716004
Vaithiyalingam S.,Arnett D.R.,Aggarwal A.,Eichman B.F.,Fanning E.,Chazin W.J.
Insights into eukaryotic primer synthesis from structures of the p48 subunit of human DNA primase.
J. Mol. Biol.
426
558-569
2014
716005
Baranovskiy A.G.,Zhang Y.,Suwa Y.,Babayeva N.D.,Gu J.,Pavlov Y.I.,Tahirov T.H.
Crystal structure of the human primase.
J. Biol. Chem.
290
5635-5646
2015
716006
Baranovskiy A.G.,Babayeva N.D.,Zhang Y.,Gu J.,Suwa Y.,Pavlov Y.I.,Tahirov T.H.
Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.
J. Biol. Chem.
291
10006-10020
2016
716007
Holzer S.,Rzechorzek N.J.,Short I.R.,Jenkyn-Bedford M.,Pellegrini L.,Kilkenny M.L.
Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
ACS Chem. Biol.
14
1904-1912
2019
