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Sequence of PLPP1_HUMAN

EC Number:3.1.3.106

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2-lysophosphatidate phosphatase
O14494
Homo sapiens
284
32156
Reaction
a 1-acyl-sn-glycerol 3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate
Other sequences found for EC No. 3.1.3.106

General information:

Sequence
show sequence in fasta format
  0 MFDKTRLPYV ALDVLCVLLA GLPFAILTSR HTPFQRGVFC NDESIKYPYK EDTIPYALLG
 60 GIIIPFSIIV IILGETLSVY CNLLHSNSFI RNNYIATIYK AIGTFLFGAA ASQSLTDIAK
120 YSIGRLRPHF LDVCDPDWSK INCSDGYIEY YICRGNAERV KEGRLSFYSG HSSFSMYCML
180 FVALYLQARM KGDWARLLRP TLQFGLVAVS IYVGLSRVSD YKHHWSDVLT GLIQGALVAI
240 LVAVYVSDFF KERTSFKERK EEDSHTTLHE TPTTGNHYPS NHQP
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
713663
Kai M.,Wada I.,Imai S.,Sakane F.,Kanoh H.
Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase.
J. Biol. Chem.
272
24572-24578
1997
713664
Leung D.W.,Tompkins C.K.,White T.
Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.
DNA Cell Biol.
17
377-385
1998
713665
Ulrix W.E.J.,Swinnen J.,Heyns W.,Verhoeven G.
Identification of the phosphatidic acid phosphatase type 2a isozyme as an androgen-regulated gene in the human prostatic Adenocarcinoma cell line LNCaP.
J. Biol. Chem.
273
4660-4665
1998
713666
Roberts R.,Sciorra V.A.,Morris A.J.
Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.
J. Biol. Chem.
273
22059-22067
1998
713667
Schmutz J.,Martin J.,Terry A.,Couronne O.,Grimwood J.,Lowry S.,Gordon L.A.,Scott D.,Xie G.,Huang W.,Hellsten U.,Tran-Gyamfi M.,She X.,Prabhakar S.,Aerts A.,Altherr M.,Bajorek E.,Black S.,Branscomb E.,Caoile C.,Challacombe J.F.,Chan Y.M.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Glavina T.,Gomez M.,Gonzales E.,Goodstein D.,Grigoriev I.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Lopez F.,Lou Y.,Martinez D.,Medina C.,Morgan J.,Nandkeshwar R.,Noonan J.P.,Pitluck S.,Pollard M.,Predki P.,Priest J.,Ramirez L.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wheeler J.,Wu K.,Yang J.,Dickson M.,Cheng J.-F.,Eichler E.E.,Olsen A.,Pennacchio L.A.,Rokhsar D.S.,Richardson P.,Lucas S.M.,Myers R.M.,Rubin E.M.
The DNA sequence and comparative analysis of human chromosome 5.
Nature
431
268-274
2004
713669
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
713670
Hooks S.B.,Ragan S.P.,Lynch K.R.
Identification of a novel human phosphatidic acid phosphatase type 2 isoform.
FEBS Lett.
427
188-192
1998
713671
Roberts R.Z.,Morris A.J.
Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators.
Biochim. Biophys. Acta
1487
33-49
2000
713672
Jia Y.J.,Kai M.,Wada I.,Sakane F.,Kanoh H.
Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells.
FEBS Lett.
552
240-246
2003
713673
Smyth S.S.,Sciorra V.A.,Sigal Y.J.,Pamulkar Z.,Wang Z.,Xu Y.,Prestwich G.D.,Morris A.J.
Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity.
J. Biol. Chem.
278
43214-43223
2003
713674
Zhao Y.,Usatyuk P.V.,Cummings R.,Saatian B.,He D.,Watkins T.,Morris A.,Spannhake E.W.,Brindley D.N.,Natarajan V.
Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells.
Biochem. J.
385
493-502
2005
713675
Kai M.,Sakane F.,Jia Y.J.,Imai S.,Yasuda S.,Kanoh H.
Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts.
J. Biochem.
140
677-686
2006
713676
Zhao Y.,Kalari S.K.,Usatyuk P.V.,Gorshkova I.,He D.,Watkins T.,Brindley D.N.,Sun C.,Bittman R.,Garcia J.G.,Berdyshev E.V.,Natarajan V.
Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1.
J. Biol. Chem.
282
14165-14177
2007