Sequence of GALT2_HUMAN

polypeptide N-acetylgalactosaminyltransferase

Q10471

571

64733

726517

White T.,Bennett E.P.,Takio K.,Soerensen T.,Bonding N.,Clausen H.

Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase.

J. Biol. Chem.

270

24156-24165

1995

726518

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

726519

Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.

The DNA sequence and biological annotation of human chromosome 1.

Nature

441

315-321

2006

726522

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

726523

Wandall H.H.,Hassan H.,Mirgorodskaya E.,Kristensen A.K.,Roepstorff P.,Bennett E.P.,Nielsen P.A.,Hollingsworth M.A.,Burchell J.,Taylor-Papadimitriou J.,Clausen H.

Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3.

J. Biol. Chem.

272

23503-23514

1997

726524

Roettger S.,White J.,Wandall H.H.,Olivo J.-C.,Stark A.,Bennett E.P.,Whitehouse C.,Berger E.G.,Clausen H.,Nilsson T.

Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus.

J. Cell Sci.

111

45-60

1998

726525

Iwasaki H.,Zhang Y.,Tachibana K.,Gotoh M.,Kikuchi N.,Kwon Y.-D.,Togayachi A.,Kudo T.,Kubota T.,Narimatsu H.

Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2.

J. Biol. Chem.

278

5613-5621

2003

726526

Soerensen A.L.,Reis C.A.,Tarp M.A.,Mandel U.,Ramachandran K.,Sankaranarayanan V.,Schwientek T.,Graham R.,Taylor-Papadimitriou J.,Hollingsworth M.A.,Burchell J.,Clausen H.

Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance.

Glycobiology

16

96-107

2006

726527

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

726528

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

726529

Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J. Proteomics

96

253-262

2014

726530

Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.

N-terminome analysis of the human mitochondrial proteome.

Proteomics

15

2519-2524

2015

726531

Noborn F.,Nilsson J.,Sihlbom C.,Nikpour M.,Kjellen L.,Larson G.

Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

Mol. Cell. Proteomics

22

100617-100617

2023

726532

Fritz T.A.,Raman J.,Tabak L.A.

Dynamic association between the catalytic and lectin domains of human UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-2.

J. Biol. Chem.

281

8613-8619

2006

726533

Lira-Navarrete E.,Iglesias-Fernandez J.,Zandberg W.F.,Companon I.,Kong Y.,Corzana F.,Pinto B.M.,Clausen H.,Peregrina J.M.,Vocadlo D.J.,Rovira C.,Hurtado-Guerrero R.

Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase2.

Angew. Chem. Int. Ed. Engl.

53

8206-8210

2014

726534

Lira-Navarrete E.,de Las Rivas M.,Companon I.,Pallares M.C.,Kong Y.,Iglesias-Fernandez J.,Bernardes G.J.,Peregrina J.M.,Rovira C.,Bernado P.,Bruscolini P.,Clausen H.,Lostao A.,Corzana F.,Hurtado-Guerrero R.

Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation.

Nat. Commun.

6

6937-6937

2015

726535

Khetarpal S.A.,Schjoldager K.T.,Christoffersen C.,Raghavan A.,Edmondson A.C.,Reutter H.M.,Ahmed B.,Ouazzani R.,Peloso G.M.,Vitali C.,Zhao W.,Somasundara A.V.,Millar J.S.,Park Y.,Fernando G.,Livanov V.,Choi S.,Noe E.,Patel P.,Ho S.P.,Kirchgessner T.G.,Wandall H.H.,Hansen L.,Bennett E.P.,Vakhrushev S.Y.,Saleheen D.,Kathiresan S.,Brown C.D.,Abou Jamra R.,LeGuern E.,Clausen H.,Rader D.J.

Loss of function of GALNT2 lowers high-density lipoproteins in humans, nonhuman primates, and rodents.

Cell Metab.

24

234-245

2016

726536

Zilmer M.,Edmondson A.C.,Khetarpal S.A.,Alesi V.,Zaki M.S.,Rostasy K.,Madsen C.G.,Lepri F.R.,Sinibaldi L.,Cusmai R.,Novelli A.,Issa M.Y.,Fenger C.D.,Abou Jamra R.,Reutter H.,Briuglia S.,Agolini E.,Hansen L.,Petaejae-Repo U.E.,Hintze J.,Raymond K.M.,Liedtke K.,Stanley V.,Musaev D.,Gleeson J.G.,Vitali C.,O'Brien W.T.,Gardella E.,Rubboli G.,Rader D.J.,Schjoldager K.T.,Moeller R.S.

Novel congenital disorder of O-linked glycosylation caused by GALNT2 loss of function.

Brain

143

1114-1126

2020