Sequence of P4HA1_CAEEL
EC Number:1.14.11.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2
General information:
Sequence
show sequence in normal format
>Q10576|procollagen-proline 4-dioxygenase|EC 1.14.11.2|Caenorhabditis elegans|Swiss-Prot
MRLALLVLATIGYAVADLFTSIADMQNLLETERNIPKILDKYIHDEEERLVQLKKLSEEY
SKKNEISIENGLKDITNPINAFLLIKRKIFDWKEIESKMNANKAGNVVSSITDDSYGVRY
PTADDLSGAAIGLLRLQDTYRLDTKDLADGKIYADQGNYTFSAKDCFEIARAAYNEHDFY
HTVMWMEEAQRRLGDEVEPTVEVEDILEYLAFALYKQNNLKHALKLTEELYKMNPTHPRA
KGNVKWYEDLLEQEGVRRSDMRKNLPPIQNRRPDSVLGNTERTMYEALCRNEVPVSQKDI
SRLYCYYKRDRPFLVYAPIKVEIKRFNPLAVLFKDVISDDEVAAIQELAKPKLARATVHD
SVTGKLVTATYRISKSAWLKEWEGDVVETVNKRIGYMTNLEMETAEELQIANYGIGGHYD
PHFDHAKKEESKSFESLGTGNRIATVLFYMSQPSHGGGTVFTEAKSTILPTKNDALFWYN
LYKQGDGNPDTRHAACPVLVGIKWVSNKWIHEKGNEFRRPCGLKSSDYERFVGDLGYGPE
PRNAPNVSPNLAKDVWETL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
726668
Veijola J.,Koivunen P.,Annunen P.,Pihlajaniemi T.,Kivirikko K.I.
Cloning, baculovirus expression, and characterization of the alpha subunit of prolyl 4-hydroxylase from the nematode Caenorhabditis elegans. This alpha subunit forms an active alpha beta dimer with the human protein disulfide isomerase/beta subunit.
J. Biol. Chem.
269
26746-26753
1994
726669
Winter A.D.,Page A.P.
Prolyl 4-hydroxylase is an essential procollagen-modifying enzyme required for exoskeleton formation and the maintenance of body shape in the nematode Caenorhabditis elegans.
Mol. Cell. Biol.
20
4084-4093
2000
726670
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science
282
2012-2018
1998
726671
Myllyharju J.,Kukkola L.,Winter A.D.,Page A.P.
The exoskeleton collagens in Caenorhabditis elegans are modified by prolyl 4-hydroxylases with unique combinations of subunits.
J. Biol. Chem.
277
29187-29196
2002
726672
Kaji H.,Saito H.,Yamauchi Y.,Shinkawa T.,Taoka M.,Hirabayashi J.,Kasai K.,Takahashi N.,Isobe T.
Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.
Nat. Biotechnol.
21
667-672
2003
726673
Kaji H.,Kamiie J.,Kawakami H.,Kido K.,Yamauchi Y.,Shinkawa T.,Taoka M.,Takahashi N.,Isobe T.
Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.
Mol. Cell. Proteomics
6
2100-2109
2007
