Sequence of L_HRSVA
EC Number:2.7.7.88
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
GDP polyribonucleotidyltransferase
P28887
Human respiratory syncytial virus A (strain A2)
2165
250386
Reaction
(5')pppAACA-[mRNA] + GDP = diphosphate + G(5')pppAACA-[mRNA]
Other sequences found for EC No. 2.7.7.88
General information:
Sequence
0 MDPIINGNSA NVYLTDSYLK GVISFSECNA LGSYIFNGPY LKNDYTNLIS RQNPLIEHMN
60 LKKLNITQSL ISKYHKGEIK LEEPTYFQSL LMTYKSMTSS EQIATTNLLK KIIRRAIEIS
120 DVKVYAILNK LGLKEKDKIK SNNGQDEDNS VITTIIKDDI LSAVKDNQSH LKADKNHSTK
180 QKDTIKTTLL KKLMCSMQHP PSWLIHWFNL YTKLNNILTQ YRSNEVKNHG FTLIDNQTLS
240 GFQFILNQYG CIVYHKELKR ITVTTYNQFL TWKDISLSRL NVCLITWISN CLNTLNKSLG
300 LRCGFNNVIL TQLFLYGDCI LKLFHNEGFY IIKEVEGFIM SLILNITEED QFRKRFYNSM
360 LNNITDAANK AQKNLLSRVC HTLLDKTVSD NIINGRWIIL LSKFLKLIKL AGDNNLNNLS
420 ELYFLFRIFG HPMVDERQAM DAVKINCNET KFYLLSSLSM LRGAFIYRII KGFVNNYNRW
480 PTLRNAIVLP LRWLTYYKLN TYPSLLELTE RDLIVLSGLR FYREFRLPKK VDLEMIINDK
540 AISPPKNLIW TSFPRNYMPS HIQNYIEHEK LKFSESDKSR RVLEYYLRDN KFNECDLYNC
600 VVNQSYLNNP NHVVSLTGKE RELSVGRMFA MQPGMFRQVQ ILAEKMIAEN ILQFFPESLT
660 RYGDLELQKI LELKAGISNK SNRYNDNYNN YISKCSIITD LSKFNQAFRY ETSCICSDVL
720 DELHGVQSLF SWLHLTIPHV TIICTYRHAP PYIGDHIVDL NNVDEQSGLY RYHMGGIEGW
780 CQKLWTIEAI SLLDLISLKG KFSITALING DNQSIDISKP IRLMEGQTHA QADYLLALNS
840 LKLLYKEYAG IGHKLKGTET YISRDMQFMS KTIQHNGVYY PASIKKVLRV GPWINTILDD
900 FKVSLESIGS LTQELEYRGE SLLCSLIFRN VWLYNQIALQ LKNHALCNNK LYLDILKVLK
960 HLKTFFNLDN IDTALTLYMN LPMLFGGGDP NLLYRSFYRR TPDFLTEAIV HSVFILSYYT
1020 NHDLKDKLQD LSDDRLNKFL TCIITFDKNP NAEFVTLMRD PQALGSERQA KITSEINRLA
1080 VTEVLSTAPN KIFSKSAQHY TTTEIDLNDI MQNIEPTYPH GLRVVYESLP FYKAEKIVNL
1140 ISGTKSITNI LEKTSAIDLT DIDRATEMMR KNITLLIRIL PLDCNRDKRE ILSMENLSIT
1200 ELSKYVRERS WSLSNIVGVT SPSIMYTMDI KYTTSTISSG IIIEKYNVNS LTRGERGPTK
1260 PWVGSSTQEK KTMPVYNRQV LTKKQRDQID LLAKLDWVYA SIDNKDEFME ELSIGTLGLT
1320 YEKAKKLFPQ YLSVNYLHRL TVSSRPCEFP ASIPAYRTTN YHFDTSPINR ILTEKYGDED
1380 IDIVFQNCIS FGLSLMSVVE QFTNVCPNRI ILIPKLNEIH LMKPPIFTGD VDIHKLKQVI
1440 QKQHMFLPDK ISLTQYVELF LSNKTLKSGS HVNSNLILAH KISDYFHNTY ILSTNLAGHW
1500 ILIIQLMKDS KGIFEKDWGE GYITDHMFIN LKVFFNAYKT YLLCFHKGYG KAKLECDMNT
1560 SDLLCVLELI DSSYWKSMSK VFLEQKVIKY ILSQDASLHR VKGCHSFKLW FLKRLNVAEF
1620 TVCPWVVNID YHPTHMKAIL TYIDLVRMGL INIDRIHIKN KHKFNDEFYT SNLFYINYNF
1680 SDNTHLLTKH IRIANSELEN NYNKLYHPTP ETLENILANP IKSNDKKTLN DYCIGKNVDS
1740 IMLPLLSNKK LIKSSAMIRT NYSKQDLYNL FPMVVIDRII DHSGNTAKSN QLYTTTSHQI
1800 SLVHNSTSLY CMLPWHHINR FNFVFSSTGC KISIEYILKD LKIKDPNCIA FIGEGAGNLL
1860 LRTVVELHPD IRYIYRSLKD CNDHSLPIEF LRLYNGHINI DYGENLTIPA TDATNNIHWS
1920 YLHIKFAEPI SLFVCDAELS VTVNWSKIII EWSKHVRKCK YCSSVNKCML IVKYHAQDDI
1980 DFKLDNITIL KTYVCLGSKL KGSEVYLVLT IGPANIFPVF NVVQNAKLIL SRTKNFIMPK
2040 KADKESIDAN IKSLIPFLCY PITKKGINTA LSKLKSVVSG DILSYSIAGR NEVFSNKLIN
2100 HKHMNILKWF NHVLNFRSTE LNYNHLYMVE STYPYLSELL NSLTTNELKK LIKITGSLLY
2160 NFHNE
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
693723
Stec D.S.,Hill M.G. III,Collins P.L.
Sequence analysis of the polymerase L gene of human respiratory syncytial virus and predicted phylogeny of nonsegmented negative-strand viruses.
Virology
183
273-287
1991
693724
Yu Q.,Hardy R.W.,Wertz G.W.
Functional cDNA clones of the human respiratory syncytial (RS) virus N, P, and L proteins support replication of RS virus genomic RNA analogs and define minimal trans-acting requirements for RNA replication.
J. Virol.
69
2412-2419
1995
693725
Connors M.,Crowe J.E. Jr.,Firestone C.Y.,Murphy B.R.,Collins P.L.
A cold-passaged, attenuated strain of human respiratory syncytial virus contains mutations in the F and L genes.
Virology
208
478-484
1995
693726
Crowe J.E. Jr.,Firestone C.Y.,Whitehead S.S.,Collins P.L.,Murphy B.R.
Acquisition of the ts phenotype by a chemically mutagenized cold-passaged human respiratory syncytial virus vaccine candidate results from the acquisition of a single mutation in the polymerase (L) gene.
Virus Genes
13
269-273
1996
693727
Firestone C.Y.,Whitehead S.S.,Collins P.L.,Murphy B.R.,Crowe J.E. Jr.
Nucleotide sequence analysis of the respiratory syncytial virus subgroup A cold-passaged (cp) temperature sensitive (ts) cpts-248/404 live attenuated virus vaccine candidate.
Virology
225
419-422
1996
693728
Whitehead S.S.,Juhasz K.,Firestone C.Y.,Collins P.L.,Murphy B.R.
Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees.
J. Virol.
72
4467-4471
1998
693729
Barik S.
Transcription of human respiratory syncytial virus genome RNA in vitro: requirement of cellular factor(s).
J. Virol.
66
6813-6818
1992
693730
Barik S.
The structure of the 5' terminal cap of the respiratory syncytial virus mRNA.
J. Gen. Virol.
74
485-490
1993
693731
Collins P.L.,Hill M.G.,Cristina J.,Grosfeld H.
Transcription elongation factor of respiratory syncytial virus, a nonsegmented negative-strand RNA virus.
Proc. Natl. Acad. Sci. U.S.A.
93
81-85
1996
693732
Kuo L.,Grosfeld H.,Cristina J.,Hill M.G.,Collins P.L.
Effects of mutations in the gene-start and gene-end sequence motifs on transcription of monocistronic and dicistronic minigenomes of respiratory syncytial virus.
J. Virol.
70
6892-6901
1996
693733
Liuzzi M.,Mason S.W.,Cartier M.,Lawetz C.,McCollum R.S.,Dansereau N.,Bolger G.,Lapeyre N.,Gaudette Y.,Lagace L.,Massariol M.J.,Do F.,Whitehead P.,Lamarre L.,Scouten E.,Bordeleau J.,Landry S.,Rancourt J.,Fazal G.,Simoneau B.
Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase.
J. Virol.
79
13105-13115
2005
693734
McGivern D.R.,Collins P.L.,Fearns R.
Identification of internal sequences in the 3' leader region of human respiratory syncytial virus that enhance transcription and confer replication processivity.
J. Virol.
79
2449-2460
2005
693735
Cowton V.M.,McGivern D.R.,Fearns R.
Unravelling the complexities of respiratory syncytial virus RNA synthesis.
J. Gen. Virol.
87
1805-1821
2006
693736
Carromeu C.,Simabuco F.M.,Tamura R.E.,Farinha Arcieri L.E.,Ventura A.M.
Intracellular localization of human respiratory syncytial virus L protein.
Arch. Virol.
152
2259-2263
2007
693737
Noton S.L.,Aljabr W.,Hiscox J.A.,Matthews D.A.,Fearns R.
Factors affecting de novo RNA synthesis and back-priming by the respiratory syncytial virus polymerase.
Virology
462
318-327
2014
693738
Sourimant J.,Rameix-Welti M.A.,Gaillard A.L.,Chevret D.,Galloux M.,Gault E.,Eleouet J.F.
Fine mapping and characterization of the L-polymerase-binding domain of the respiratory syncytial virus phosphoprotein.
J. Virol.
89
4421-4433
2015
693739
Fearns R.,Plemper R.K.
Polymerases of paramyxoviruses and pneumoviruses.
Virus Res.
234
87-102
2017
693740
Cressey T.N.,Noton S.L.,Nagendra K.,Braun M.R.,Fearns R.
Mechanism for de novo initiation at two sites in the respiratory syncytial virus promoter.
Nucleic Acids Res.
46
6785-6796
2018
693741
Pan J.,Qian X.,Lattmann S.,El Sahili A.,Yeo T.H.,Jia H.,Cressey T.,Ludeke B.,Noton S.,Kalocsay M.,Fearns R.,Lescar J.
Structure of the human metapneumovirus polymerase phosphoprotein complex.
Nature
577
275-279
2020
693742
Sutto-Ortiz P.,Tcherniuk S.,Ysebaert N.,Abeywickrema P.,Noel M.,Decombe A.,Debart F.,Vasseur J.J.,Canard B.,Roymans D.,Rigaux P.,Eleouet J.F.,Decroly E.
The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2'-O-methylation.
PLoS Pathog.
17
0-0
2021
693743
Gilman M.S.A.,Liu C.,Fung A.,Behera I.,Jordan P.,Rigaux P.,Ysebaert N.,Tcherniuk S.,Sourimant J.,Eleouet J.F.,Sutto-Ortiz P.,Decroly E.,Roymans D.,Jin Z.,McLellan J.S.
Structure of the Respiratory Syncytial Virus Polymerase Complex.
Cell
179
193-0
2019
693744
Cao D.,Gao Y.,Roesler C.,Rice S.,D'Cunha P.,Zhuang L.,Slack J.,Domke M.,Antonova A.,Romanelli S.,Keating S.,Forero G.,Juneja P.,Liang B.
Cryo-EM structure of the respiratory syncytial virus RNA polymerase.
Nat. Commun.
11
368-368
2020
