Sequence of LIPA_SACS2
EC Number:2.8.1.8
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
lipoyl synthase
Q97U63
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
285
32111
Reaction
[protein]-N6-(octanoyl)-L-lysine + an [Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster + 2 S-adenosyl-L-methionine + 2 oxidized [2Fe-2S] ferredoxin + 6 H+ = [protein]-N6-[(R)-dihydrolipoyl]-L-lysine + an [Fe-S] cluster scaffold protein + 2 sulfide + 4 Fe3+ + 2 L-methionine + 2 5'-deoxyadenosine + 2 reduced [2Fe-2S] ferredoxin
Other sequences found for EC No. 2.8.1.8
General information:
Sequence
0 MEKKVQIAVY ENENFKRVAE IVKKKSIATV CEEALCPNIM ECWGSGTATF MIMGSICTRG
60 CRFCYVLKGK PSPLDDEEPK RVAEAVKEME LDYVVITSVD RDDLSDGGAQ HFANVVKTVK
120 ELNPGIIVEV LTPDFRGNID AVKKVIDAGV DVFAHNVETV RRLTPIVRDP RASYEQSLNV
180 LKYAENVIKK SSILLGLGET WDEIVETMRD LRSVGVSILV LSQYMRPSRK QLEVKKRYTL
240 EEFKELEEIA YSMGFSAVIS LPLARTSYKA KEAYFRAIEN AKNHS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
691925
She Q.,Singh R.K.,Confalonieri F.,Zivanovic Y.,Allard G.,Awayez M.J.,Chan-Weiher C.C.-Y.,Clausen I.G.,Curtis B.A.,De Moors A.,Erauso G.,Fletcher C.,Gordon P.M.K.,Heikamp-de Jong I.,Jeffries A.C.,Kozera C.J.,Medina N.,Peng X.,Thi-Ngoc H.P.,Redder P.,Schenk M.E.,Theriault C.,Tolstrup N.,Charlebois R.L.,Doolittle W.F.,Duguet M.,Gaasterland T.,Garrett R.A.,Ragan M.A.,Sensen C.W.,Van der Oost J.
The complete genome of the crenarchaeon Sulfolobus solfataricus P2.
Proc. Natl. Acad. Sci. U.S.A.
98
7835-7840
2001
691926
Bryant P.,Kriek M.,Wood R.J.,Roach P.L.
The activity of a thermostable lipoyl synthase from Sulfolobus solfataricus with a synthetic octanoyl substrate.
Anal. Biochem.
351
44-49
2006
691927
Harmer J.E.,Hiscox M.J.,Dinis P.C.,Fox S.J.,Iliopoulos A.,Hussey J.E.,Sandy J.,Van Beek F.T.,Essex J.W.,Roach P.L.
Structures of lipoyl synthase reveal a compact active site for controlling sequential sulfur insertion reactions.
Biochem. J.
464
123-133
2014
