Sequence of GEDA_ASPTN
EC Number:2.1.1.283
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
emodin O-methyltransferase
Q0CCY5
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
486
53916
Reaction
S-adenosyl-L-methionine + emodin = S-adenosyl-L-homocysteine + questin
General information:
Sequence
0 MERQPKSLSD AVQLLQTTEI ISKCTQTIIA EWSNEAETFK KRASSGRAGA ELVLPSHELF
60 NAQRTITAAI GKLIELVSEP SVRILEIAGQ YQESRALYIA VERRIPDILA SQDNEGGMPV
120 KELSSRTGIE YRKLSRILRY LCSMGTFRQV GPDVFANNTI SACLVANEPL RAYVRLTGSE
180 AFTASDRLPK TLLDPSTGPS YDVTRTAWQD AIGTTKPRWE WIEERVEPDK LLDSGYHYPG
240 IPSLILEPQP PGEDGLVARP ELEIMGLAMV GGGRVFGAAH VFDFPWASLD NALVVDVGGG
300 VGGFALQLSK VYPDLRFVIQ DRGPVIQQAL ESVWPNENPA ALKDQRVQFM EHSFFDKNPV
360 EGADVYYLRY VLHDWSDDYC VNILSHIRES MAPHSRLLIC EQVMNTTIGD PDLTSAPAPL
420 PANYGFHARF SHSRDLTMMA AINGIERTPE EFKTILKSAG LALKQIWECR SQVSLLEAVR
480 ADARTA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
711838
Fujii I.,Ebizuka Y.,Sankawa U.
A novel anthraquinone ring cleavage enzyme from Aspergillus terreus.
J. Biochem.
103
878-883
1988
711839
Fujii I.,Chen Z.G.,Ebizuka Y.,Sankawa U.
Identification of emodinanthrone oxygenase in fungus Aspergillus terreus.
Biochem. Int.
25
1043-1049
1991
711840
Chen Z.G.,Fujii I.,Ebizuka Y.,Sankawa U.
Emodin O-methyltransferase from Aspergillus terreus.
Arch. Microbiol.
158
29-34
1992
711841
Huang K.X.,Fujii I.,Ebizuka Y.,Gomi K.,Sankawa U.
Molecular cloning and heterologous expression of the gene encoding dihydrogeodin oxidase, a multicopper blue enzyme from Aspergillus terreus.
J. Biol. Chem.
270
21495-21502
1995
711842
Shinohara C.,Chikanishi T.,Nakashima S.,Hashimoto A.,Hamanaka A.,Endo A.,Hasumi K.
Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B.
J. Antibiot.
53
262-268
2000
711843
Askenazi M.,Driggers E.M.,Holtzman D.A.,Norman T.C.,Iverson S.,Zimmer D.P.,Boers M.E.,Blomquist P.R.,Martinez E.J.,Monreal A.W.,Feibelman T.P.,Mayorga M.E.,Maxon M.E.,Sykes K.,Tobin J.V.,Cordero E.,Salama S.R.,Trueheart J.,Royer J.C.,Madden K.T.
Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains.
Nat. Biotechnol.
21
150-156
2003
711844
Sato S.,Okusa N.,Ogawa A.,Ikenoue T.,Seki T.,Tsuji T.
Identification and preliminary SAR studies of (+)-Geodin as a glucose uptake stimulator for rat adipocytes.
J. Antibiot.
58
583-589
2005
711845
Awakawa T.,Yokota K.,Funa N.,Doi F.,Mori N.,Watanabe H.,Horinouchi S.
Physically discrete beta-lactamase-type thioesterase catalyzes product release in atrochrysone synthesis by iterative type I polyketide synthase.
Chem. Biol.
16
613-623
2009
711846
Nielsen M.T.,Nielsen J.B.,Anyaogu D.C.,Holm D.K.,Nielsen K.F.,Larsen T.O.,Mortensen U.H.
Heterologous reconstitution of the intact geodin gene cluster in Aspergillus nidulans through a simple and versatile PCR based approach.
PLoS ONE
8
E72871-E72871
2013
