Sequence of HMDH1_ASPFU
EC Number:1.1.1.34
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
hydroxymethylglutaryl-CoA reductase (NADPH)
Q4WHZ1
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
1130
121271
Reaction
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
Other sequences found for EC No. 1.1.1.34
General information:
Sequence
0 MATSLITRKL RSAEATNDVE PGWLKRQVTG VLQSISSHAC QHPIHTIVVI ALLASTTYVG
60 LLEGSLFDSV RNSRNIAGQV DVDTLLQGSR NLRLGESTSW KWQVEDSLAS QDYTGVNHLA
120 LTTFIFSDSL SKSSSIAPAA TELPIPSNAS AQPVPFTPNL FSPFSHDSSL AFTLPFDQVP
180 QFLKAVQEIP DTSSDEDDGE QKKWIMRAAR GSAYGSGGAI KLWLADAWGS FVDLIKHAET
240 IDIVIMTLGY LSMHLSFVSL FFSMRRLGSN FWLAATVLFS GVFAFLFGLL VTTKLGVPIN
300 VLLLSEGLPF LVVTIGFEKP IILTRAVLTA AADNRGRAGQ ASSSTTKSIQ DSIQTAIKEQ
360 GFEIIRDYCI EIAILIAGAA SGVQGGLRQF CFLAAWILFF DCVLLFTFYT TILCIKLEIN
420 RIKRHITLRK ALEEDGITHR VAENVASSND WPLTESESSN KTSIFGRKLR SSSVRRFKIL
480 MVGGFVLVNV VNLSTIPFRD SSQGAGLPLL SRVSNVFAPT PIDPFKVAEN GLDSIYVSAK
540 SQMMETVVTV IPPIKYKLEY PSVYYAALGE SRTFDIEYTD QFLDAVGGRV IESLLKSIED
600 PIISKWIIAA LTLSIILNGY LFNAARWSIK EPEVAPVPAA PTVAVVEAKK EYPKIDLNPD
660 TPKRSLEECE AFLKEKRAAY LSDEELIELS LRGKIPGYAL EKTMENEDLM SRVDAFTRAV
720 KIRRAVVART PATSAITGSL ECSKLPYKDY NYTLVHGACC ENVIGYLPLP LGVAGPLTID
780 GQSYFIPMAT TEGVLVASTS RGAKAINAGG GAVTVLTGDG MTRGPCVGFP TLARAAAAKV
840 WIDSEEGRSI LTAAFNSTSR FARLQHLKTA LAGTYLYIRF KTTTGDAMGM NMISKGVEKA
900 LHVMATECGF DDMATISVSG NFCTDKKAAA INWIDGRGKS VVAEAIIPGD VVRSVLKSDV
960 NALVELNTSK NLIGSAMAGS VGGFNAHASN IVTAVFLATG QDPAQNVESS SCITTMRNLN
1020 GNLQIAVSMP SIEVGTIGGG TILEAQSAML DMLGVRGSHP TNPGDNARQL ARIVAAAVLA
1080 GELSLCSALA AGHLVRAHMA HNRSAATTRT STPVSAAVSA ARGLTMSSSE
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
682121
Nierman W.C.,Pain A.,Anderson M.J.,Wortman J.R.,Kim H.S.,Arroyo J.,Berriman M.,Abe K.,Archer D.B.,Bermejo C.,Bennett J.W.,Bowyer P.,Chen D.,Collins M.,Coulsen R.,Davies R.,Dyer P.S.,Farman M.L.,Fedorova N.,Fedorova N.D.,Feldblyum T.V.,Fischer R.,Fosker N.,Fraser A.,Garcia J.L.,Garcia M.J.,Goble A.,Goldman G.H.,Gomi K.,Griffith-Jones S.,Gwilliam R.,Haas B.J.,Haas H.,Harris D.E.,Horiuchi H.,Huang J.,Humphray S.,Jimenez J.,Keller N.,Khouri H.,Kitamoto K.,Kobayashi T.,Konzack S.,Kulkarni R.,Kumagai T.,Lafton A.,Latge J.-P.,Li W.,Lord A.,Lu C.,Majoros W.H.,May G.S.,Miller B.L.,Mohamoud Y.,Molina M.,Monod M.,Mouyna I.,Mulligan S.,Murphy L.D.,O'Neil S.,Paulsen I.,Penalva M.A.,Pertea M.,Price C.,Pritchard B.L.,Quail M.A.,Rabbinowitsch E.,Rawlins N.,Rajandream M.A.,Reichard U.,Renauld H.,Robson G.D.,Rodriguez de Cordoba S.,Rodriguez-Pena J.M.,Ronning C.M.,Rutter S.,Salzberg S.L.,Sanchez M.,Sanchez-Ferrero J.C.,Saunders D.,Seeger K.,Squares R.,Squares S.,Takeuchi M.,Tekaia F.,Turner G.,Vazquez de Aldana C.R.,Weidman J.,White O.,Woodward J.R.,Yu J.-H.,Fraser C.M.,Galagan J.E.,Asai K.,Machida M.,Hall N.,Barrell B.G.,Denning D.W.
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.
Nature
438
1151-1156
2005
682122
Ferreira M.E.,Colombo A.L.,Paulsen I.,Ren Q.,Wortman J.,Huang J.,Goldman M.H.,Goldman G.H.
The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus.
Med. Mycol.
43
0-0
2005
682123
Yasmin S.,Alcazar-Fuoli L.,Gruendlinger M.,Puempel T.,Cairns T.,Blatzer M.,Lopez J.F.,Grimalt J.O.,Bignell E.,Haas H.
Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus.
Proc. Natl. Acad. Sci. U.S.A.
109
0-0
2012
682124
Zhang J.,van den Heuvel J.,Debets A.J.M.,Verweij P.E.,Melchers W.J.G.,Zwaan B.J.,Schoustra S.E.
Evolution of cross-resistance to medical triazoles in Aspergillus fumigatus through selection pressure of environmental fungicides.
Proc. R. Soc. B
284
0-0
2017
682125
Rybak J.M.,Ge W.,Wiederhold N.P.,Parker J.E.,Kelly S.L.,Rogers P.D.,Fortwendel J.R.
Mutations in hmg1, challenging the paradigm of clinical triazole resistance in Aspergillus fumigatus.
MBio
10
0-0
2019
