Sequence of CBPC5_MOUSE
EC Number:3.4.17.24
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
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Reaction
This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins. The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions. In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17, tubulinyl-Tyr carboxypeptidase). The latter is cleaved to delta2-tubulin and further to delta3-tubulin.
General information:
Sequence
0 MELRCGGLLF SSRFDSGNLA HVEKVETVSS DGEGVGGVAT APASGSAASP DYEFNVWTRP
60 DCAETEYENG NRSWFYFSVR GGTPGKLIKI NIMNMNKQSK LYSQGMAPFV RTLPSRPRWE
120 RIRERPTFEM TETQFVLSFV HRFVEGRGAT TFFAFCYPFS YSDCQDLLSQ LDQRFSENYS
180 THSSPLDSIY YHRELLCYSL DGLRVDLLTI TSCHGLRDDR EPRLEQLFPD LGTPRPFRFT
240 GKRIFFLSSR VHPGETPSSF VFNGFLDFIL RPDDPRAQTL RRLFVFKLIP MLNPDGVVRG
300 HYRTDSRGVN LNRQYLKPDA VLHPAIYGAK AVLLYHHVHS RLNAKSPTNQ QPTLHLPPEA
360 PLSDLEKANN LHNEAHLGQS PDGENPATWP ETEPAEEKTD PVWLMPQPIP ELEEPAPDTI
420 PPKESGVAYY VDLHGHASKR GCFMYGNSFS DESTQVENML YPKLISLNSA HFDFQGCNFS
480 EKNMYARDRR DGQSKEGSGR VAIYKASGII HSYTLECNYN TGRSVNSIPA ACHDNGRASP
540 PPPPAFPSRY TVELFEQVGR AMAIAALDMA ECNPWPRIVL SEHSSLTNLR AWMLRHVRNS
600 RGLTSAGNMG ASKKRGARTP PKSNNSLPVS CSENALSRVR SFSTGTSTGG SSSSQQNSPQ
660 MKNSPSFPFH GSRTAGLPGL GSSTQKVSHR VLGPVREPRC SDRRRRQQPL NHRSTTSSLA
720 PSPTLASSGP TSSRNMGSCL LPNSLSLSGS SCSFSSSGDK PEAVMVIGKS LLGAGARIPC
780 IRTRLQARPR LGRSSPPTRR GMRGSSPTSP IPQTRESSEL EPGPHSATPG LPQAGPPRPR
840 SAPAFSPISC TLSDSPSRIC YSRGLLNQCE VCFVPKSPPL TISPRV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
708695
Kalinina E.,Biswas R.,Berezniuk I.,Hermoso A.,Aviles F.X.,Fricker L.D.
A novel subfamily of mouse cytosolic carboxypeptidases.
FASEB J.
21
836-850
2007
708696
Carninci P.,Kasukawa T.,Katayama S.,Gough J.,Frith M.C.,Maeda N.,Oyama R.,Ravasi T.,Lenhard B.,Wells C.,Kodzius R.,Shimokawa K.,Bajic V.B.,Brenner S.E.,Batalov S.,Forrest A.R.,Zavolan M.,Davis M.J.,Wilming L.G.,Aidinis V.,Allen J.E.,Ambesi-Impiombato A.,Apweiler R.,Aturaliya R.N.,Bailey T.L.,Bansal M.,Baxter L.,Beisel K.W.,Bersano T.,Bono H.,Chalk A.M.,Chiu K.P.,Choudhary V.,Christoffels A.,Clutterbuck D.R.,Crowe M.L.,Dalla E.,Dalrymple B.P.,de Bono B.,Della Gatta G.,di Bernardo D.,Down T.,Engstrom P.,Fagiolini M.,Faulkner G.,Fletcher C.F.,Fukushima T.,Furuno M.,Futaki S.,Gariboldi M.,Georgii-Hemming P.,Gingeras T.R.,Gojobori T.,Green R.E.,Gustincich S.,Harbers M.,Hayashi Y.,Hensch T.K.,Hirokawa N.,Hill D.,Huminiecki L.,Iacono M.,Ikeo K.,Iwama A.,Ishikawa T.,Jakt M.,Kanapin A.,Katoh M.,Kawasawa Y.,Kelso J.,Kitamura H.,Kitano H.,Kollias G.,Krishnan S.P.,Kruger A.,Kummerfeld S.K.,Kurochkin I.V.,Lareau L.F.,Lazarevic D.,Lipovich L.,Liu J.,Liuni S.,McWilliam S.,Madan Babu M.,Madera M.,Marchionni L.,Matsuda H.,Matsuzawa S.,Miki H.,Mignone F.,Miyake S.,Morris K.,Mottagui-Tabar S.,Mulder N.,Nakano N.,Nakauchi H.,Ng P.,Nilsson R.,Nishiguchi S.,Nishikawa S.,Nori F.,Ohara O.,Okazaki Y.,Orlando V.,Pang K.C.,Pavan W.J.,Pavesi G.,Pesole G.,Petrovsky N.,Piazza S.,Reed J.,Reid J.F.,Ring B.Z.,Ringwald M.,Rost B.,Ruan Y.,Salzberg S.L.,Sandelin A.,Schneider C.,Schoenbach C.,Sekiguchi K.,Semple C.A.,Seno S.,Sessa L.,Sheng Y.,Shibata Y.,Shimada H.,Shimada K.,Silva D.,Sinclair B.,Sperling S.,Stupka E.,Sugiura K.,Sultana R.,Takenaka Y.,Taki K.,Tammoja K.,Tan S.L.,Tang S.,Taylor M.S.,Tegner J.,Teichmann S.A.,Ueda H.R.,van Nimwegen E.,Verardo R.,Wei C.L.,Yagi K.,Yamanishi H.,Zabarovsky E.,Zhu S.,Zimmer A.,Hide W.,Bult C.,Grimmond S.M.,Teasdale R.D.,Liu E.T.,Brusic V.,Quackenbush J.,Wahlestedt C.,Mattick J.S.,Hume D.A.,Kai C.,Sasaki D.,Tomaru Y.,Fukuda S.,Kanamori-Katayama M.,Suzuki M.,Aoki J.,Arakawa T.,Iida J.,Imamura K.,Itoh M.,Kato T.,Kawaji H.,Kawagashira N.,Kawashima T.,Kojima M.,Kondo S.,Konno H.,Nakano K.,Ninomiya N.,Nishio T.,Okada M.,Plessy C.,Shibata K.,Shiraki T.,Suzuki S.,Tagami M.,Waki K.,Watahiki A.,Okamura-Oho Y.,Suzuki H.,Kawai J.,Hayashizaki Y.
The transcriptional landscape of the mammalian genome.
Science
309
1559-1563
2005
708697
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
E1000112-E1000112
2009
708698
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
708699
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
708700
Rogowski K.,van Dijk J.,Magiera M.M.,Bosc C.,Deloulme J.C.,Bosson A.,Peris L.,Gold N.D.,Lacroix B.,Grau M.B.,Bec N.,Larroque C.,Desagher S.,Holzer M.,Andrieux A.,Moutin M.J.,Janke C.
A family of protein-deglutamylating enzymes associated with neurodegeneration.
Cell
143
564-578
2010
708701
Kimura Y.,Kurabe N.,Ikegami K.,Tsutsumi K.,Konishi Y.,Kaplan O.I.,Kunitomo H.,Iino Y.,Blacque O.E.,Setou M.
Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs).
J. Biol. Chem.
285
22936-22941
2010
708702
Berezniuk I.,Lyons P.J.,Sironi J.J.,Xiao H.,Setou M.,Angeletti R.H.,Ikegami K.,Fricker L.D.
Cytosolic carboxypeptidase 5 removes alpha- and gamma-linked glutamates from tubulin.
J. Biol. Chem.
288
30445-30453
2013
708703
Tort O.,Tanco S.,Rocha C.,Bieche I.,Seixas C.,Bosc C.,Andrieux A.,Moutin M.J.,Aviles F.X.,Lorenzo J.,Janke C.
The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids.
Mol. Biol. Cell
25
3017-3027
2014
708704
Xia P.,Ye B.,Wang S.,Zhu X.,Du Y.,Xiong Z.,Tian Y.,Fan Z.
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.
Nat. Immunol.
17
369-378
2016
