Sequence of KGP1_BOVIN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
cGMP-dependent protein kinase
P00516
Bos taurus
671
76419
Reaction
ATP + a protein = ADP + a phosphoprotein
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MSELEEDFAK ILMLKEERIK ELEKRLSEKE EEIQELKRKL HKCQSVLPVP STHIGPRTTR
 60 AQGISAEPQT YRSFHDLRQA FRKFTKSERS KDLIKEAILD NDFMKNLELS QIQEIVDCMY
120 PVEYGKDSCI IKEGDVGSLV YVMEDGKVEV TKEGVKLCTM GPGKVFGELA ILYNCTRTAT
180 VKTLVNVKLW AIDRQCFQTI MMRTGLIKHT EYMEFLKSVP TFQSLPEEIL SKLADVLEET
240 HYENGEYIIR QGARGDTFFI ISKGKVNVTR EDSPNEDPVF LRTLGKGDWF GEKALQGEDV
300 RTANVIAAEA VTCLVIDRDS FKHLIGGLDD VSNKAYEDAE AKAKYEAEAA FFANLKLSDF
360 NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF
420 IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI
480 IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD
540 YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDNPS
600 ERLGNLKNGV KDIQKHKWFE GFNWEGLRKG TLTPPIIPSV ASPTDTSNFD SFPEDNDEPP
660 PDDNSGWDID F
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
667534
Wernet W.,Flockerzi V.,Hofmann F.
The cDNA of the two isoforms of bovine cGMP-dependent protein kinase.
FEBS Lett.
251
191-196
1989
667535
Ruth P.,Pfeifer A.,Kamm S.,Klatt P.,Dostmann W.R.,Hofmann F.
Identification of the amino acid sequences responsible for high affinity activation of cGMP kinase Ialpha.
J. Biol. Chem.
272
10522-10528
1997
667536
Takio K.,Wade R.D.,Smith S.B.,Krebs E.G.,Walsh K.A.,Titani K.
Guanosine cyclic 3',5'-phosphate dependent protein kinase, a chimeric protein homologous with two separate protein families.
Biochemistry
23
4207-4218
1984
667537
Takio K.,Smith S.B.,Walsh K.A.,Krebs E.G.,Titani K.
Amino acid sequence around a 'hinge' region and its 'autophosphorylation' site in bovine lung cGMP-dependent protein kinase.
J. Biol. Chem.
258
5531-5536
1983
667538
Wolfe L.,Francis S.H.,Corbin J.D.
Properties of a cGMP-dependent monomeric protein kinase from bovine aorta.
J. Biol. Chem.
264
4157-4162
1989
667539
Hashimoto E.,Takio K.,Krebs E.G.
Amino acid sequence at the ATP-binding site of cGMP-dependent protein kinase.
J. Biol. Chem.
257
727-733
1982
667540
Heil W.G.,Landgraf W.,Hofmann F.
A catalytically active fragment of cGMP-dependent protein kinase. Occupation of its cGMP-binding sites does not affect its phosphotransferase activity.
Eur. J. Biochem.
168
117-121
1987
667541
Keilbach A.,Ruth P.,Hofmann F.
Detection of cGMP dependent protein kinase isozymes by specific antibodies.
Eur. J. Biochem.
208
467-473
1992
667542
Schlossmann J.,Ammendola A.,Ashman K.,Zong X.,Huber A.,Neubauer G.,Wang G.-X.,Allescher H.-D.,Korth M.,Wilm M.,Hofmann F.,Ruth P.
Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta.
Nature
404
197-201
2000
667543
Ammendola A.,Geiselhoeringer A.,Hofmann F.,Schlossmann J.
Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta.
J. Biol. Chem.
276
24153-24159
2001
667544
Koller A.,Schlossmann J.,Ashman K.,Uttenweiler-Joseph S.,Ruth P.,Hofmann F.
Association of phospholamban with a cGMP kinase signaling complex.
Biochem. Biophys. Res. Commun.
300
155-160
2003
667545
Casteel D.E.,Boss G.R.,Pilz R.B.
Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif.
J. Biol. Chem.
280
38211-38218
2005
667546
Osborne B.W.,Wu J.,McFarland C.J.,Nickl C.K.,Sankaran B.,Casteel D.E.,Woods V.L. Jr.,Kornev A.P.,Taylor S.S.,Dostmann W.R.
Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication.
Structure
19
1317-1327
2011